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A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.
Sinha S, Subramanian S, Proctor TM, Kaler LJ, Grafe M, Dahan R, Huan J, Vandenbark AA, Burrows GG, Offner H. Sinha S, et al. J Neurosci. 2007 Nov 14;27(46):12531-9. doi: 10.1523/JNEUROSCI.3599-07.2007. J Neurosci. 2007. PMID: 18003831 Free PMC article.
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.
Sinha S, Miller L, Subramanian S, McCarty OJ, Proctor T, Meza-Romero R, Huan J, Burrows GG, Vandenbark AA, Offner H. Sinha S, et al. J Neuroimmunol. 2010 Aug 25;225(1-2):52-61. doi: 10.1016/j.jneuroim.2010.04.013. Epub 2010 May 23. J Neuroimmunol. 2010. PMID: 20546940 Free PMC article.
RTL therapy for multiple sclerosis: a Phase I clinical study.
Offner H, Sinha S, Burrows GG, Ferro AJ, Vandenbark AA. Offner H, et al. Among authors: sinha s. J Neuroimmunol. 2011 Feb;231(1-2):7-14. doi: 10.1016/j.jneuroim.2010.09.013. Epub 2010 Oct 20. J Neuroimmunol. 2011. PMID: 20965577 Free PMC article. Clinical Trial.
6,481 results