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ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo.
Samuelsen Ø, Åstrand OAH, Fröhlich C, Heikal A, Skagseth S, Carlsen TJO, Leiros HS, Bayer A, Schnaars C, Kildahl-Andersen G, Lauksund S, Finke S, Huber S, Gjøen T, Andresen AMS, Økstad OA, Rongved P. Samuelsen Ø, et al. Among authors: skagseth s. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19. doi: 10.1128/AAC.02415-19. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32179522 Free PMC article.
α-Aminophosphonate inhibitors of metallo-β-lactamases NDM-1 and VIM-2.
Palica K, Deufel F, Skagseth S, Di Santo Metzler GP, Thoma J, Andersson Rasmussen A, Valkonen A, Sunnerhagen P, Leiros HS, Andersson H, Erdelyi M. Palica K, et al. Among authors: skagseth s. RSC Med Chem. 2023 Aug 2;14(11):2277-2300. doi: 10.1039/d3md00286a. eCollection 2023 Nov 15. RSC Med Chem. 2023. PMID: 38020072 Free PMC article.
Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters.
Palica K, Vorácová M, Skagseth S, Andersson Rasmussen A, Allander L, Hubert M, Sandegren L, Schrøder Leiros HK, Andersson H, Erdélyi M. Palica K, et al. Among authors: skagseth s. ACS Omega. 2022 Jan 25;7(5):4550-4562. doi: 10.1021/acsomega.1c06527. eCollection 2022 Feb 8. ACS Omega. 2022. PMID: 35155946 Free PMC article.
Computational design of the temperature optimum of an enzyme reaction.
van der Ent F, Skagseth S, Lund BA, Sočan J, Griese JJ, Brandsdal BO, Åqvist J. van der Ent F, et al. Among authors: skagseth s. Sci Adv. 2023 Jun 28;9(26):eadi0963. doi: 10.1126/sciadv.adi0963. Epub 2023 Jun 28. Sci Adv. 2023. PMID: 37379391 Free PMC article.