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Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis.
Larsen J, Lambert M, Pettersson H, Vifian T, Larsen M, Ollerstam A, Hegardt P, Eskilsson C, Laursen S, Soehoel A, Skak-Nielsen T, Hansen LM, Knudsen NØ, Eirefelt S, Sørensen MD, Stilou TG, Nielsen SF. Larsen J, et al. Among authors: skak nielsen t. J Med Chem. 2020 Dec 10;63(23):14502-14521. doi: 10.1021/acs.jmedchem.0c00797. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33054196
Macrolide Inspired Macrocycles as Modulators of the IL-17A/IL-17RA Interaction.
Koštrun S, Fajdetić A, Pešić D, Brajša K, Bencetić Mihaljević V, Jelić D, Petrinić Grba A, Elenkov I, Rupčić R, Kapić S, Ozimec Landek I, Butković K, Grgičević A, Žiher D, Čikoš A, Padovan J, Saxty G, Dack K, Bladh H, Skak-Nielsen T, Feldbaek Nielsen S, Lambert M, Stahlhut M. Koštrun S, et al. Among authors: skak nielsen t. J Med Chem. 2021 Jun 24;64(12):8354-8383. doi: 10.1021/acs.jmedchem.1c00327. Epub 2021 Jun 8. J Med Chem. 2021. PMID: 34100601
Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of pro-inflammatory cytokines.
Funding AT, Johansen C, Kragballe K, Otkjaer K, Jensen UB, Madsen MW, Fjording MS, Finnemann J, Skak-Nielsen T, Paludan SR, Iversen L. Funding AT, et al. Among authors: skak nielsen t. J Invest Dermatol. 2006 Aug;126(8):1784-91. doi: 10.1038/sj.jid.5700252. Epub 2006 Mar 16. J Invest Dermatol. 2006. PMID: 16543895 Free article.
27 results