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208 results

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Page 1
Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma.
Dong L, Lu D, Chen R, Lin Y, Zhu H, Zhang Z, Cai S, Cui P, Song G, Rao D, Yi X, Wu Y, Song N, Liu F, Zou Y, Zhang S, Zhang X, Wang X, Qiu S, Zhou J, Wang S, Zhang X, Shi Y, Figeys D, Ding L, Wang P, Zhang B, Rodriguez H, Gao Q, Gao D, Zhou H, Fan J. Dong L, et al. Cancer Cell. 2022 Jan 10;40(1):70-87.e15. doi: 10.1016/j.ccell.2021.12.006. Epub 2021 Dec 30. Cancer Cell. 2022. PMID: 34971568 Free article.
These proteomic subgroups had distinct features in prognosis, genetic alterations, microenvironment dysregulation, tumor microbiota composition, and potential therapeutics. SLC16A3 and HKDC1 were further identified as potential prognostic biomarkers associated with metabol …
These proteomic subgroups had distinct features in prognosis, genetic alterations, microenvironment dysregulation, tumor microbiota composit …
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors.
Dvorak V, Casiraghi A, Colas C, Koren A, Tomek T, Offensperger F, Rukavina A, Tin G, Hahn E, Dobner S, Frommelt F, Boeszoermenyi A, Bernada V, Hannich JT, Ecker GF, Winter GE, Kubicek S, Superti-Furga G. Dvorak V, et al. Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28. Cell Chem Biol. 2023. PMID: 37516113 Free PMC article.
In this study we leveraged synthetic lethality between the lactate transporters SLC16A1 and SLC16A3 in a screening strategy that we call paralog-dependent isogenic cell assay (PARADISO). The system involves five isogenic cell lines, each dependent on various paralog genes …
In this study we leveraged synthetic lethality between the lactate transporters SLC16A1 and SLC16A3 in a screening strategy that we c …
Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A.
Choi SH, Kim MY, Yoon YS, Koh DI, Kim MK, Cho SY, Kim KS, Hur MW. Choi SH, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Aug;1862(8):771-785. doi: 10.1016/j.bbagrm.2019.06.004. Epub 2019 Jul 1. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 31271899
However, how SLC16A3 expression is regulated, under hypoxic conditions, is poorly understood. ...Consequently, we hypothesized that FBI-1 might regulate SLC16A3 and/or HIF-1 expression. Transient transfection and transcription assays of SLC16A3 promoter repor …
However, how SLC16A3 expression is regulated, under hypoxic conditions, is poorly understood. ...Consequently, we hypothesized that F …
Lactate Transporter SLC16A3 (MCT4) as an Onco-Immunological Biomarker Associating Tumor Microenvironment and Immune Responses in Lung Cancer.
Tao Q, Li X, Zhu T, Ge X, Gong S, Guo J, Ma R. Tao Q, et al. Int J Gen Med. 2022 Apr 27;15:4465-4474. doi: 10.2147/IJGM.S353592. eCollection 2022. Int J Gen Med. 2022. PMID: 35509603 Free PMC article.
However, the role of SLC16A3 in immune infiltration and immunosuppression of lung cancer is largely unknown. ...METHODS: SLC16A3 expression was evaluated with TCGA database. Kaplan-Meier analysis was performed for survival rates. ...
However, the role of SLC16A3 in immune infiltration and immunosuppression of lung cancer is largely unknown. ...METHODS: SLC16A3 …
Prognostic Value of SLC16A3(MCT4) in Lung Adenocarcinoma and Its Clinical Significance.
Xue L, Liu J, Xie J, Luo J. Xue L, et al. Int J Gen Med. 2021 Nov 17;14:8413-8425. doi: 10.2147/IJGM.S337615. eCollection 2021. Int J Gen Med. 2021. PMID: 34819749 Free PMC article.
Further studies have shown that SLC16A3 is involved in some metabolic pathways. Not only that, SLC16A3 is associated with immune cell infiltration and tumor mutation burden (TMB). CONCLUSION: SLC16A3 has good prognostic significance in lung adenocarcinoma, ba …
Further studies have shown that SLC16A3 is involved in some metabolic pathways. Not only that, SLC16A3 is associated with immu …
Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming.
Yu T, Liu Z, Tao Q, Xu X, Li X, Li Y, Chen M, Liu R, Chen D, Wu M, Yu J. Yu T, et al. Cancer Lett. 2024 May 1;589:216824. doi: 10.1016/j.canlet.2024.216824. Epub 2024 Mar 22. Cancer Lett. 2024. PMID: 38522774
We validated that Slc16a3 expression in tumor cells negatively correlated with anti-PD-1 efficiency. ...Our study therefore demonstrates that tumor cell-intrinsic SLC16A3 may be a potential target to reverse tumor resistance to immunotherapy....
We validated that Slc16a3 expression in tumor cells negatively correlated with anti-PD-1 efficiency. ...Our study therefore demonstra …
LINC00035 Transcriptional Regulation of SLC16A3 via CEBPB Affects Glycolysis and Cell Apoptosis in Ovarian Cancer.
Yang S, Wang J, Cheng R, Pang B, Sun P. Yang S, et al. Evid Based Complement Alternat Med. 2021 Oct 11;2021:5802082. doi: 10.1155/2021/5802082. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34671407 Free PMC article. Retracted.
LINC00035 could recruit CEBPB into the SLC16A3 promoter region, thus increasing the SLC16A3 transcription. SLC16A3 was upregulated in OC tissues. SLC16A3 knockdown exerted similar effects on SKOV3 and A2780 cells as LINC00035 knockdown. ...
LINC00035 could recruit CEBPB into the SLC16A3 promoter region, thus increasing the SLC16A3 transcription. SLC16A3 was …
The SLC16 gene family - structure, role and regulation in health and disease.
Halestrap AP. Halestrap AP. Mol Aspects Med. 2013 Apr-Jun;34(2-3):337-49. doi: 10.1016/j.mam.2012.05.003. Mol Aspects Med. 2013. PMID: 23506875 Review.
The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies …
The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, …
SOX2 mediates metabolic reprogramming of prostate cancer cells.
de Wet L, Williams A, Gillard M, Kregel S, Lamperis S, Gutgesell LC, Vellky JE, Brown R, Conger K, Paner GP, Wang H, Platz EA, De Marzo AM, Mu P, Coloff JL, Szmulewitz RZ, Vander Griend DJ. de Wet L, et al. Oncogene. 2022 Feb;41(8):1190-1202. doi: 10.1038/s41388-021-02157-x. Epub 2022 Jan 24. Oncogene. 2022. PMID: 35067686 Free PMC article.
Analyses of SOX2 gene targets with central functions metabolism (CERK, ECHS1, HS6SDT1, LPCAT4, PFKP, SLC16A3, SLC46A1, and TST) document significant expression correlation with SOX2 among RNA-Seq datasets derived from patient tumors and metastases. ...
Analyses of SOX2 gene targets with central functions metabolism (CERK, ECHS1, HS6SDT1, LPCAT4, PFKP, SLC16A3, SLC46A1, and TST) docum …
208 results