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Page 1
The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction.
Clémençon B, Babot M, Trézéguet V. Clémençon B, et al. Mol Aspects Med. 2013 Apr-Jun;34(2-3):485-93. doi: 10.1016/j.mam.2012.05.006. Mol Aspects Med. 2013. PMID: 23506884 Review.
The objective of this review is to summarize the current knowledge of the involvement of the ADP/ATP carrier, encoded by the SLC25A4, SLC25A5, SLC25A6 and SLC25A31 genes, in human diseases and of the efforts made at designing different model systems to study this carrier a …
The objective of this review is to summarize the current knowledge of the involvement of the ADP/ATP carrier, encoded by the SLC25A4, SLC25A …
Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans.
Katsukunya JN, Soko ND, Naidoo J, Rayner B, Blom D, Sinxadi P, Chimusa ER, Dandara M, Dzobo K, Jones E, Dandara C. Katsukunya JN, et al. Int J Hypertens. 2023 May 30;2023:9919677. doi: 10.1155/2023/9919677. eCollection 2023. Int J Hypertens. 2023. PMID: 38633331 Free PMC article. Review.
In this paper, we discuss the implications of genetic diversity in CYP11B2, GRK4, NEDD4L, NPPA, SCNN1B, UMOD, CYP411, WNK, CYP3A4/5, ACE, ADBR1/2, GNB3, NOS3, B2, BEST3, SLC25A31, LRRC15 genes, and chromosome 12q loci on hypertension susceptibility and response to antihype …
In this paper, we discuss the implications of genetic diversity in CYP11B2, GRK4, NEDD4L, NPPA, SCNN1B, UMOD, CYP411, WNK, CYP3A4/5, ACE, AD …
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cho J, Seo J, Lim CH, Yang L, Shiratsuchi T, Lee MH, Chowdhury RR, Kasahara H, Kim JS, Oh SP, Lee YJ, Terada N. Cho J, et al. Cell Death Differ. 2015 Sep;22(9):1437-50. doi: 10.1038/cdd.2014.230. Epub 2015 Jan 23. Cell Death Differ. 2015. PMID: 25613378 Free PMC article.
Mice have three ANT paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5) and Ant4 (Slc25a31), which are expressed in a tissue-dependent manner. While knockout mice have been characterized with Ant1 and Ant4 genes, which resulted in exercise intolerance and male infertility, respective …
Mice have three ANT paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5) and Ant4 (Slc25a31), which are expressed in a tissue-dependent manner. W …
A conserved E2F6-binding element in murine meiosis-specific gene promoters.
Kehoe SM, Oka M, Hankowski KE, Reichert N, Garcia S, McCarrey JR, Gaubatz S, Terada N. Kehoe SM, et al. Biol Reprod. 2008 Nov;79(5):921-30. doi: 10.1095/biolreprod.108.067645. Epub 2008 Jul 30. Biol Reprod. 2008. PMID: 18667754 Free PMC article.
Here we demonstrate that E2F6, a member of the E2F family of transcription factors, is essential for the repression of the newly identified meiosis-specific gene, Slc25a31 (also known as Ant4, Aac4), in somatic cells. This discovery, along with previous studies, prompted u …
Here we demonstrate that E2F6, a member of the E2F family of transcription factors, is essential for the repression of the newly identified …
Fertility Relevance Probability Analysis Shortlists Genetic Markers for Male Fertility Impairment.
Greither T, Schumacher J, Dejung M, Behre HM, Zischler H, Butter F, Herlyn H. Greither T, et al. Cytogenet Genome Res. 2020;160(9):506-522. doi: 10.1159/000511117. Epub 2020 Nov 25. Cytogenet Genome Res. 2020. PMID: 33238277 Free article.
Additional candidate markers are DDX4, SHCBP1L, CCDC155, ODF1, DMRTB1, ASZ1, BOLL, FKBP6, SLC25A31, PRSS21, and RNF17. FRP inference additionally provides clues for potential new markers, thereunder TEX37 and POU4F2. ...
Additional candidate markers are DDX4, SHCBP1L, CCDC155, ODF1, DMRTB1, ASZ1, BOLL, FKBP6, SLC25A31, PRSS21, and RNF17. FRP inference …
Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.
Gong Y, Wang Z, Beitelshees AL, McDonough CW, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Bailey KR, Boerwinkle E, Chapman AB, Turner ST, Cooper-DeHoff RM, Johnson JA. Gong Y, et al. Hypertension. 2016 Mar;67(3):556-63. doi: 10.1161/HYPERTENSIONAHA.115.06345. Epub 2016 Jan 4. Hypertension. 2016. PMID: 26729753 Free PMC article.
Two variants discovered in the monotherapy meta-analysis were validated in the add-on therapy. African American participants heterozygous for SLC25A31 rs201279313 deletion versus wild-type genotype had better diastolic BP response to atenolol monotherapy, metoprolol monoth …
Two variants discovered in the monotherapy meta-analysis were validated in the add-on therapy. African American participants heterozygous fo …
Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.
Lim CH, Brower JV, Resnick JL, Oh SP, Terada N. Lim CH, et al. Reprod Sci. 2015 Feb;22(2):250-7. doi: 10.1177/1933719114542026. Epub 2014 Jul 16. Reprod Sci. 2015. PMID: 25031318 Free PMC article.
Mice have 3 Ant paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5), and Ant4 (Slc25a31), which are expressed in a tissue-dependent manner. We previously identified that Ant4 was expressed exclusively in testicular germ cells in adult mice and essential for spermatogenesis and subseq …
Mice have 3 Ant paralogs, Ant1 (Slc25a4), Ant2 (Slc25a5), and Ant4 (Slc25a31), which are expressed in a tissue-dependent manner. We p …
Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.
Hamazaki T, Leung WY, Cain BD, Ostrov DA, Thorsness PE, Terada N. Hamazaki T, et al. PLoS One. 2011 Apr 21;6(4):e19250. doi: 10.1371/journal.pone.0019250. PLoS One. 2011. PMID: 21532989 Free PMC article.
Recently a novel germ cell-specific member of the ANT family, ANT4 (SLC25A31) was identified. Although it is known that targeted depletion of ANT4 in mice resulted in male infertility, the functional biochemical differences between ANT4 and other somatic ANT isoforms remai …
Recently a novel germ cell-specific member of the ANT family, ANT4 (SLC25A31) was identified. Although it is known that targeted depl …
Identification of genomic characteristics and selective signals in Guizhou black goat.
Chang L, Zheng Y, Li S, Niu X, Huang S, Long Q, Ran X, Wang J. Chang L, et al. BMC Genomics. 2024 Feb 9;25(1):164. doi: 10.1186/s12864-023-09954-6. BMC Genomics. 2024. PMID: 38336605 Free PMC article.
Functional annotation analysis revealed that these genes are potentially responsible for the immune response (e.g., CD28, CD274, IL1A, TLR2, and SLC25A31), humility-cold resistance (e.g., HBEGF, SOSTDC1, ARNT, COL4A1/2, and EP300), meat quality traits (e.g., CHUK, GAB2, PL …
Functional annotation analysis revealed that these genes are potentially responsible for the immune response (e.g., CD28, CD274, IL1A, TLR2, …
Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.
Brower JV, Lim CH, Jorgensen M, Oh SP, Terada N. Brower JV, et al. Reproduction. 2009 Sep;138(3):463-70. doi: 10.1530/REP-09-0201. Epub 2009 Jun 25. Reproduction. 2009. PMID: 19556438 Free PMC article.
We recently identified and characterized a novel testis specific Ant, ANT4 (also known as SLC25A31 and Aac4). The generation of Ant4-deficient animals resulted in the severe disruption of the seminiferous epithelium with an apparent spermatocytic arrest of the germ cell po …
We recently identified and characterized a novel testis specific Ant, ANT4 (also known as SLC25A31 and Aac4). The generation of Ant4- …
20 results