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85 results

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A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis.
Zou H, Poore B, Brown EE, Qian J, Xie B, Asimakidou E, Razskazovskiy V, Ayrapetian D, Sharma V, Xia S, Liu F, Chen A, Guan Y, Li Z, Wanggou S, Saulnier O, Ly M, Fellows-Mayle W, Xi G, Tomita T, Resnick AC, Mack SC, Raabe EH, Eberhart CG, Sun D, Stronach BE, Agnihotri S, Kohanbash G, Lu S, Herrup K, Rich JN, Gittes GK, Broniscer A, Hu Z, Li X, Pollack IF, Friedlander RM, Hainer SJ, Taylor MD, Hu B. Zou H, et al. Nat Cell Biol. 2023 Mar;25(3):493-507. doi: 10.1038/s41556-023-01093-0. Epub 2023 Feb 27. Nat Cell Biol. 2023. PMID: 36849558 Free PMC article.
We further identify that a core set of transcription factors, enhancer of zeste homologue 2 (EZH2) and nuclear factor I X (NFIX), coordinates with the cis-regulatory elements at the SMARCD3 locus to form a chromatin hub to control SMARCD3 expression in the developin …
We further identify that a core set of transcription factors, enhancer of zeste homologue 2 (EZH2) and nuclear factor I X (NFIX), coordinate …
Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma.
Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T. Ferguson LP, et al. Nat Commun. 2023 Jan 18;14(1):292. doi: 10.1038/s41467-023-35796-7. Nat Commun. 2023. PMID: 36653361 Free PMC article.
Diverse genetic mouse models of pancreatic cancer and stage-specific Smarcd3 deletion reveal that Smarcd3 loss preferentially impacts established tumors, improving survival especially in context of chemotherapy. Mechanistically, SMARCD3 acts with FOXA1 to con …
Diverse genetic mouse models of pancreatic cancer and stage-specific Smarcd3 deletion reveal that Smarcd3 loss preferentially …
SMARCD3 is a potential prognostic marker and therapeutic target in CAFs.
Jiang M, Wang H, Chen H, Han Y. Jiang M, et al. Aging (Albany NY). 2020 Oct 28;12(20):20835-20861. doi: 10.18632/aging.104102. Epub 2020 Oct 28. Aging (Albany NY). 2020. PMID: 33125346 Free PMC article.
Function analyses indicated that MSARCD3 might promote CAFs activation and colorectal cancer metastasis through SMARCD3-WNT5A/TGF-beta-MAPK14-SMARCD3 positive feedback loop. Signaling map of SMARCD3 was constructed and several potential drugs that could regul …
Function analyses indicated that MSARCD3 might promote CAFs activation and colorectal cancer metastasis through SMARCD3-WNT5A/TGF-bet …
LncRNA SMARCD3-OT1 Promotes Muscle Hypertrophy and Fast-Twitch Fiber Transformation via Enhancing SMARCD3X4 Expression.
Zhang J, Cai B, Ma M, Kong S, Zhou Z, Zhang X, Nie Q. Zhang J, et al. Int J Mol Sci. 2022 Apr 19;23(9):4510. doi: 10.3390/ijms23094510. Int J Mol Sci. 2022. PMID: 35562902 Free PMC article.
In conclusion, SMARCD3-OT1 can improve the expression of SMARCD3X4, thus inducing muscle hypertrophy. In addition, SMARCD3-OT1 can facilitate slow-twitch fibers to transform into fast-twitch fibers....
In conclusion, SMARCD3-OT1 can improve the expression of SMARCD3X4, thus inducing muscle hypertrophy. In addition, SMARCD3-OT1 …
The SWI/SNF subunit SMARCD3 regulates cell cycle progression and predicts survival outcome in ER+ breast cancer.
Tropée R, de la Peña Avalos B, Gough M, Snell C, Duijf PHG, Dray E. Tropée R, et al. Breast Cancer Res Treat. 2021 Feb;185(3):601-614. doi: 10.1007/s10549-020-05997-5. Epub 2020 Nov 12. Breast Cancer Res Treat. 2021. PMID: 33180234 Free PMC article.
METHODS: The level of SMARCD3 was detected by immunohistochemistry in breast cancer patient samples, and expression levels of SMARCD1, SMARCD2, and SMARCD3 were investigated using publicly available datasets from large cohorts of breast cancer patients. ...CONCLUSIO …
METHODS: The level of SMARCD3 was detected by immunohistochemistry in breast cancer patient samples, and expression levels of SMARCD1 …
lncRNA UCA1 promotes tumor progression by targeting SMARCD3 in cervical cancer.
An L, Dong K, Chi S, Wei S, Zhang J, Yu Z, Zhang Q, Zhang T, Cheng S, Shi R, Jin Z, Zhou X, Zhao Y, Wang H. An L, et al. Mol Carcinog. 2024 Mar;63(3):384-399. doi: 10.1002/mc.23659. Epub 2023 Dec 20. Mol Carcinog. 2024. PMID: 38116886
Functional studies indicated that UCA1 promotes CC progression. Mechanically, UCA1 downregulated the SMARCD3 protein stabilization by promoting SMARCD3 ubiquitination. Taken together, we revealed that the UCA1/SMARCD3 axis promoted CC progression, which could …
Functional studies indicated that UCA1 promotes CC progression. Mechanically, UCA1 downregulated the SMARCD3 protein stabilization by …
Smarcd3 regulates the timing of zebrafish myogenesis onset.
Ochi H, Hans S, Westerfield M. Ochi H, et al. J Biol Chem. 2008 Feb 8;283(6):3529-3536. doi: 10.1074/jbc.M708594200. Epub 2007 Dec 3. J Biol Chem. 2008. PMID: 18056260 Free article.
In zebrafish, fgf8 and ntl expression commences during blastula stages, whereas myogenesis, as indicated by myod expression, does not begin until much later during mid-gastrula stages. smarcd3b expression, on the other hand, becomes enriched in the marginal zone just prior to the …
In zebrafish, fgf8 and ntl expression commences during blastula stages, whereas myogenesis, as indicated by myod expression, does not begin …
SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling.
Jordan NV, Prat A, Abell AN, Zawistowski JS, Sciaky N, Karginova OA, Zhou B, Golitz BT, Perou CM, Johnson GL. Jordan NV, et al. Mol Cell Biol. 2013 Aug;33(15):3011-25. doi: 10.1128/MCB.01443-12. Epub 2013 May 28. Mol Cell Biol. 2013. PMID: 23716599 Free PMC article.
These mammary epithelial cells expressing Smarcd3/Baf60c had upregulated Wnt5a expression. Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3/Baf60c-induced EMT. Thus, Smarcd3/Baf60c epigenetically regulates EMT by activating W …
These mammary epithelial cells expressing Smarcd3/Baf60c had upregulated Wnt5a expression. Inhibition of Wnt5a by either RNAi knockdo …
Identification and analysis of lipid metabolism-related genes in allergic rhinitis.
Tao Q, Zhu Y, Wang T, Deng Y, Liu H, Wu J. Tao Q, et al. Lipids Health Dis. 2023 Jul 21;22(1):105. doi: 10.1186/s12944-023-01825-z. Lipids Health Dis. 2023. PMID: 37480069 Free PMC article.
In addition, two immune cells, regulatory T cells (Treg) and T follicular helper cells (TFH), were marked variations between control and AR groups, and SMARCD3 was significantly associated with TFH. Moreover, SMARCD3 was relevant to immune-related pathways, and corr …
In addition, two immune cells, regulatory T cells (Treg) and T follicular helper cells (TFH), were marked variations between control and AR …
85 results