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1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer.
Kilgour MK, MacPherson S, Zacharias LG, Ellis AE, Sheldon RD, Liu EY, Keyes S, Pauly B, Carleton G, Allard B, Smazynski J, Williams KS, Watson PH, Stagg J, Nelson BH, DeBerardinis RJ, Jones RG, Hamilton PT, Lum JJ. Kilgour MK, et al. Among authors: smazynski j. Sci Adv. 2021 Jan 20;7(4):eabe1174. doi: 10.1126/sciadv.abe1174. Print 2021 Jan. Sci Adv. 2021. PMID: 33523930 Free PMC article.
Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function.
MacPherson S, Keyes S, Kilgour MK, Smazynski J, Chan V, Sudderth J, Turcotte T, Devlieger A, Yu J, Huggler KS, Cantor JR, DeBerardinis RJ, Siatskas C, Lum JJ. MacPherson S, et al. Among authors: smazynski j. Mol Ther Methods Clin Dev. 2022 Feb 15;24:380-393. doi: 10.1016/j.omtm.2022.02.004. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2022. PMID: 35284590 Free PMC article.
A tumor-restricted glycoform of podocalyxin is a highly selective marker of immunologically cold high-grade serous ovarian carcinoma.
Brassard J, Hughes MR, Dean P, Hernaez DC, Thornton S, Banville AC, Smazynski J, Warren M, Zhang K, Milne K, Gilks CB, Mes-Masson AM, Huntsman DG, Nelson BH, Roskelley CD, McNagny KM. Brassard J, et al. Among authors: smazynski j. Front Oncol. 2023 Dec 21;13:1286754. doi: 10.3389/fonc.2023.1286754. eCollection 2023. Front Oncol. 2023. PMID: 38188285 Free PMC article.
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