Smith BJ - Search Results

1

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.

Hosea NA, Collard WT, Cole S, Maurer TS, Fang RX, Jones H, Kakar SM, Nakai Y, Smith BJ, Webster R, Beaumont K. Hosea NA, et al. Among authors: smith bj. J Clin Pharmacol. 2009 May;49(5):513-33. doi: 10.1177/0091270009333209. Epub 2009 Mar 19. J Clin Pharmacol. 2009. PMID: 19299532

2

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.

Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C. Doran A, et al. Among authors: smith bj. Drug Metab Dispos. 2005 Jan;33(1):165-74. doi: 10.1124/dmd.104.001230. Epub 2004 Oct 22. Drug Metab Dispos. 2005. PMID: 15502009

3

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J. Liu X, et al. Among authors: smith bj. J Pharmacol Exp Ther. 2005 Jun;313(3):1254-62. doi: 10.1124/jpet.104.079319. Epub 2005 Mar 2. J Pharmacol Exp Ther. 2005. PMID: 15743928

4

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J. Liu X, et al. Among authors: smith bj. Drug Metab Dispos. 2006 Sep;34(9):1443-7. doi: 10.1124/dmd.105.008201. Epub 2006 Jun 7. Drug Metab Dispos. 2006. PMID: 16760229

5

Single-dose pharmacokinetics of varenicline, a selective nicotinic receptor partial agonist, in healthy smokers and nonsmokers.

Faessel HM, Smith BJ, Gibbs MA, Gobey JS, Clark DJ, Burstein AH. Faessel HM, et al. Among authors: smith bj. J Clin Pharmacol. 2006 Sep;46(9):991-8. doi: 10.1177/0091270006290669. J Clin Pharmacol. 2006. PMID: 16920893 Clinical Trial.

6

Utility of Mdr1-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development.

Chen C, Liu X, Smith BJ. Chen C, et al. Among authors: smith bj. Curr Drug Metab. 2003 Aug;4(4):272-91. doi: 10.2174/1389200033489415. Curr Drug Metab. 2003. PMID: 12871045 Review.

7

Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models.

Yamazaki S, Vicini P, Shen Z, Zou HY, Lee J, Li Q, Christensen JG, Smith BJ, Shetty B. Yamazaki S, et al. Among authors: smith bj. J Pharmacol Exp Ther. 2012 Mar;340(3):549-57. doi: 10.1124/jpet.111.188870. Epub 2011 Nov 30. J Pharmacol Exp Ther. 2012. PMID: 22129595

8

Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects.

Johnson TR, Tan W, Goulet L, Smith EB, Yamazaki S, Walker GS, O'Gorman MT, Bedarida G, Zou HY, Christensen JG, Nguyen LN, Shen Z, Dalvie D, Bello A, Smith BJ. Johnson TR, et al. Among authors: smith eb, smith bj. Xenobiotica. 2015 Jan;45(1):45-59. doi: 10.3109/00498254.2014.941964. Epub 2014 Jul 18. Xenobiotica. 2015. PMID: 25034009

9

Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model.

Yamazaki S, Johnson TR, Smith BJ. Yamazaki S, et al. Among authors: smith bj. Drug Metab Dispos. 2015 Oct;43(10):1417-29. doi: 10.1124/dmd.115.064618. Epub 2015 Jul 15. Drug Metab Dispos. 2015. PMID: 26180127 Clinical Trial.

10

Application of target-mediated drug disposition model to small molecule heat shock protein 90 inhibitors.

Yamazaki S, Shen Z, Jiang Y, Smith BJ, Vicini P. Yamazaki S, et al. Among authors: smith bj. Drug Metab Dispos. 2013 Jun;41(6):1285-94. doi: 10.1124/dmd.113.051490. Epub 2013 Apr 4. Drug Metab Dispos. 2013. PMID: 23557746

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