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A new effector pathway links ATM kinase with the DNA damage response.
Demonacos C, Krstic-Demonacos M, Smith L, Xu D, O'Connor DP, Jansson M, La Thangue NB. Demonacos C, et al. Among authors: smith l. Nat Cell Biol. 2004 Oct;6(10):968-76. doi: 10.1038/ncb1170. Epub 2004 Sep 19. Nat Cell Biol. 2004. PMID: 15448695
Chk2 activates E2F-1 in response to DNA damage.
Stevens C, Smith L, La Thangue NB. Stevens C, et al. Among authors: smith l. Nat Cell Biol. 2003 May;5(5):401-9. doi: 10.1038/ncb974. Nat Cell Biol. 2003. PMID: 12717439
ATM and Chk2 kinase target the p53 cofactor Strap.
Adams CJ, Graham AL, Jansson M, Coutts AS, Edelmann M, Smith L, Kessler B, La Thangue NB. Adams CJ, et al. Among authors: smith l. EMBO Rep. 2008 Dec;9(12):1222-9. doi: 10.1038/embor.2008.186. Epub 2008 Oct 3. EMBO Rep. 2008. PMID: 18833288 Free PMC article.
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