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An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.
Southwell AL, Smith-Dijak A, Kay C, Sepers M, Villanueva EB, Parsons MP, Xie Y, Anderson L, Felczak B, Waltl S, Ko S, Cheung D, Dal Cengio L, Slama R, Petoukhov E, Raymond LA, Hayden MR. Southwell AL, et al. Among authors: smith dijak a. Hum Mol Genet. 2016 Sep 1;25(17):3654-3675. doi: 10.1093/hmg/ddw212. Epub 2016 Jul 4. Hum Mol Genet. 2016. PMID: 27378694 Free PMC article.
Altered cortical processing of sensory input in Huntington disease mouse models.
Sepers MD, Mackay JP, Koch E, Xiao D, Mohajerani MH, Chan AW, Smith-Dijak AI, Ramandi D, Murphy TH, Raymond LA. Sepers MD, et al. Among authors: smith dijak ai. Neurobiol Dis. 2022 Jul;169:105740. doi: 10.1016/j.nbd.2022.105740. Epub 2022 Apr 20. Neurobiol Dis. 2022. PMID: 35460870 Free article.
Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function.
Lang-Ouellette D, Gruver KM, Smith-Dijak A, Blot FGC, Stewart CA, de Vanssay de Blavous P, Li CH, Van Eitrem C, Rosen C, Faust PL, Schonewille M, Watt AJ. Lang-Ouellette D, et al. Among authors: smith dijak a. Nat Commun. 2021 Jul 5;12(1):4129. doi: 10.1038/s41467-021-24390-4. Nat Commun. 2021. PMID: 34226561 Free PMC article.