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2018 2
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2020 7
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2023 6
2024 3

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29 results

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The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9.
Wang Y, Wang M, Chen J, Li Y, Kuang Z, Dende C, Raj P, Quinn G, Hu Z, Srinivasan T, Hassell B, Ruhn KA, Behrendt CL, Liang T, Dou X, Song Z, Hooper LV. Wang Y, et al. Science. 2023 Aug 25;381(6660):851-857. doi: 10.1126/science.ade0522. Epub 2023 Aug 24. Science. 2023. PMID: 37616368 Free PMC article.
Forced expression of Snhg9 in the intestinal epithelium of conventional mice impaired lipid absorption, reduced body fat, and protected against diet-induced obesity. The microbiota repressed Snhg9 expression through an immune relay encompassing myeloid cells and gro …
Forced expression of Snhg9 in the intestinal epithelium of conventional mice impaired lipid absorption, reduced body fat, and protect …
A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling.
Li RH, Tian T, Ge QW, He XY, Shi CY, Li JH, Zhang Z, Liu FZ, Sang LJ, Yang ZZ, Liu YZ, Xiong Y, Yan Q, Li X, Ju HQ, Liu J, Wang LJ, Shao JZ, Wang W, Zhou T, Lin A. Li RH, et al. Cell Res. 2021 Oct;31(10):1088-1105. doi: 10.1038/s41422-021-00530-9. Epub 2021 Jul 15. Cell Res. 2021. PMID: 34267352 Free PMC article.
Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically, ex …
Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase …
SNHG9/miR-214-5p/SOX4 feedback loop regulates osteosarcoma progression.
Bai CJ, Gao T, Liu JY, Li S, Wang XY, Fan ZF. Bai CJ, et al. Neoplasma. 2022 Sep;69(5):1175-1184. doi: 10.4149/neo_2022_220228N218. Epub 2022 Aug 24. Neoplasma. 2022. PMID: 36004648
In this study, we found SNHG9 overexpression in OS tissues and cells. In addition, downregulated SNHG9 expression impaired the proliferation, migration, and invasion abilities of OS cells. SNHG9 expression was positively regulated by the transcription factor …
In this study, we found SNHG9 overexpression in OS tissues and cells. In addition, downregulated SNHG9 expression impaired the …
SNHG9 promotes Hepatoblastoma Tumorigenesis via miR-23a-5p/Wnt3a Axis.
Feng SG, Bhandari R, Ya L, Zhixuan B, Qiuhui P, Jiabei Z, Sewi M, Ni Z, Jing W, Fenyong S, Ji M, Bhandari R. Feng SG, et al. J Cancer. 2021 Aug 22;12(20):6031-6049. doi: 10.7150/jca.60748. eCollection 2021. J Cancer. 2021. PMID: 34539877 Free PMC article.
SNHG9 role in Cisplatin drug resistance in hepatoblastoma was also determined. Results: SNHG9 was significantly upregulated in hepatoblastoma tissue and cell lines. ...
SNHG9 role in Cisplatin drug resistance in hepatoblastoma was also determined. Results: SNHG9 was significantly upregulated in …
Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated cardiomyopathy via miR-326/EPHB3 axis.
Zhang F, Shi H, Xue H, Li H, Li C, Han Q. Zhang F, et al. J Thromb Thrombolysis. 2023 May;55(4):634-648. doi: 10.1007/s11239-023-02798-7. Epub 2023 Apr 1. J Thromb Thrombolysis. 2023. PMID: 37004604
Furthermore, we determined the serum SNHG9 expression level of the doxorubicin (Dox)-induced DCM mice model, and found that the upregulated SNHG9 is negatively associated with heart function. Besides, the deletion of SNHG9 by AAV-9 alleviated heart injury in …
Furthermore, we determined the serum SNHG9 expression level of the doxorubicin (Dox)-induced DCM mice model, and found that the upreg …
SNHG9/miR-199a-5p/Wnt2 Axis Regulates Cell Growth and Aerobic Glycolysis in Glioblastoma.
Zhang H, Qin D, Jiang Z, Zhang J. Zhang H, et al. J Neuropathol Exp Neurol. 2019 Oct 1;78(10):939-948. doi: 10.1093/jnen/nlz078. J Neuropathol Exp Neurol. 2019. PMID: 31504670
The Wnt2 levels were determined by qRT-PCR and Western blot. Results showed that the mRNA expression of SNHG9 was elevated in glioblastoma tissues. The elevated SNHG9 expression was related to lower survival rate in patients with glioma. SNHG9 could downregul …
The Wnt2 levels were determined by qRT-PCR and Western blot. Results showed that the mRNA expression of SNHG9 was elevated in gliobla …
SNHG9 was upregulated in NSCLC and associated with DDP-resistance and poor prognosis of NSCLC patients.
Wang R, Chen C, Kang W, Meng G. Wang R, et al. Am J Transl Res. 2020 Aug 15;12(8):4456-4466. eCollection 2020. Am J Transl Res. 2020. PMID: 32913519 Free PMC article.
Besides, silence of SNHG9 suppressed DDP resistance of NSCLC cells. Furthermore, CAPRIN1 was positively regulated by SNHG9 and mediated the promoting role of SNHG9 in DDP resistance of NSCLC cells. SNHG9 could be used as a potential target for DDP resi …
Besides, silence of SNHG9 suppressed DDP resistance of NSCLC cells. Furthermore, CAPRIN1 was positively regulated by SNHG9 and …
Long noncoding RNA SNHG9 facilitates growth of glioma stem-like cells via miR-326/SOX9 axis.
Wang CJ, Chao CR, Zhao WF, Liu HM, Feng JS, Cui YX. Wang CJ, et al. J Gene Med. 2022 Jan;24(1):e3334. doi: 10.1002/jgm.3334. Epub 2021 Apr 13. J Gene Med. 2022. PMID: 33789359
SNHG9 overexpression promoted GSC cell growth, whereas SNHG9 knockdown inhibited GSC cell growth. ...Moreover, transfection with miR-326 inhibitor counteracted SNHG9 knockdown-mediated inhibition of GSC cell growth. CONCLUSIONS: SNHG9 facilitates growt …
SNHG9 overexpression promoted GSC cell growth, whereas SNHG9 knockdown inhibited GSC cell growth. ...Moreover, transfection wi …
LncRNA SNHG9 is a prognostic biomarker and correlated with immune infiltrates in prostate cancer.
Li C, Hu J, Hu X, Zhao C, Mo M, Zu X, Li Y. Li C, et al. Transl Androl Urol. 2021 Jan;10(1):215-226. doi: 10.21037/tau-20-1134. Transl Androl Urol. 2021. PMID: 33532311 Free PMC article.
We aimed to demonstrate the relationship between SNHG9 and PCa based on The Cancer Genome Atlas (TCGA) database. METHODS: Kruskal-Wallis test, Wilcoxon signed-rank test, and logistic regression were used to evaluate relationships between clinical-pathologic features and …
We aimed to demonstrate the relationship between SNHG9 and PCa based on The Cancer Genome Atlas (TCGA) database. METHODS: Kruskal-Wal …
LncRNA SNHG9 is Downregulated in Non-Small Cell Lung Cancer and Suppressed miR-21 Through Methylation to Promote Cell Proliferation.
Wang D, Cao X, Han Y, Yu D. Wang D, et al. Cancer Manag Res. 2020 Aug 31;12:7941-7948. doi: 10.2147/CMAR.S253052. eCollection 2020. Cancer Manag Res. 2020. PMID: 32943928 Free PMC article.
Correlations were analyzed by linear regression. The interaction between miR-21 and SNHG9 was detected using RNA pull-down. The expression relationship between SNHG9 and miR-21 was analyzed by SNHG9 or miR-21 overexpression experiments. ...In contrast, miR-21 …
Correlations were analyzed by linear regression. The interaction between miR-21 and SNHG9 was detected using RNA pull-down. The expre …
29 results