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Year Number of Results
1981 2
1982 1
1984 2
1985 3
1986 6
1987 12
1988 7
1989 15
1990 5
1991 17
1992 15
1993 26
1994 32
1995 51
1996 54
1997 55
1998 92
1999 62
2000 62
2001 94
2002 112
2003 140
2004 152
2005 172
2006 177
2007 158
2008 155
2009 152
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2013 172
2014 175
2015 174
2016 160
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2019 185
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2024 79

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4,013 results

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Page 1
Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation.
Wang Y, Zhang S, Yang X, Hwang JK, Zhan C, Lian C, Wang C, Gui T, Wang B, Xie X, Dai P, Zhang L, Tian Y, Zhang H, Han C, Cai Y, Hao Q, Ye X, Liu X, Liu J, Cao Z, Huang S, Song J, Pan-Hammarström Q, Zhao Y, Alt FW, Zheng X, Da LT, Yeap LS, Meng FL. Wang Y, et al. Cell. 2023 May 11;186(10):2193-2207.e19. doi: 10.1016/j.cell.2023.03.030. Epub 2023 Apr 24. Cell. 2023. PMID: 37098343 Free article.
Somatic hypermutation (SHM), initiated by activation-induced cytidine deaminase (AID), generates mutations in the antibody-coding sequence to allow affinity maturation. ...Our results show a non-coding role of antibody-coding sequence in directing hypermutation …
Somatic hypermutation (SHM), initiated by activation-induced cytidine deaminase (AID), generates mutations in the antibody-cod …
RNA-directed DNA repair and antibody somatic hypermutation.
Franklin A, Steele EJ. Franklin A, et al. Trends Genet. 2022 May;38(5):426-436. doi: 10.1016/j.tig.2021.10.005. Epub 2021 Nov 2. Trends Genet. 2022. PMID: 34740453 Review.
Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) pairs. ...
Somatic hypermutation at antibody loci affects both deoxyadenosine-deoxythymidine (A/T) and deoxycytidine-deoxyguanosine (C/G) …
AID function in somatic hypermutation and class switch recombination.
Yu K. Yu K. Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):759-766. doi: 10.3724/abbs.2022070. Acta Biochim Biophys Sin (Shanghai). 2022. PMID: 35975606 Free PMC article. Review.
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig heavy chain constant regions. ...
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of immunoglobulin (Ig) gene variable regions and c …
What Targets Somatic Hypermutation to the Immunoglobulin Loci?
Heltzel JMH, Gearhart PJ. Heltzel JMH, et al. Viral Immunol. 2020 May;33(4):277-281. doi: 10.1089/vim.2019.0149. Epub 2019 Nov 26. Viral Immunol. 2020. PMID: 31770070 Free PMC article. Review.
Thus, the immunoglobulin loci are unique in that a favorable combination of DNA sequences and 3' transcription enhancers make them the perfect storm for AID-induced somatic hypermutation....
Thus, the immunoglobulin loci are unique in that a favorable combination of DNA sequences and 3' transcription enhancers make them the perfe …
Somatic hypermutation of immunoglobulin genes.
Wagner SD, Neuberger MS. Wagner SD, et al. Annu Rev Immunol. 1996;14:441-57. doi: 10.1146/annurev.immunol.14.1.441. Annu Rev Immunol. 1996. PMID: 8962691 Review.
The relationship between somatic hypermutation and affinity maturation in the mouse is delineated. ...The use that different species make of somatic hypermutation to generate either the primary or secondary B cell repertoire is considered. ...
The relationship between somatic hypermutation and affinity maturation in the mouse is delineated. ...The use that different s …
Mismatch repair deficiency: The what, how and why it is important.
Olave MC, Graham RP. Olave MC, et al. Genes Chromosomes Cancer. 2022 Jun;61(6):314-321. doi: 10.1002/gcc.23015. Epub 2021 Dec 9. Genes Chromosomes Cancer. 2022. PMID: 34837268 Review.
It is involved in mitotic and meiotic recombination, apoptosis, immunoglobulin gene rearrangement, somatic hypermutation, and other processes. Deficiencies in mismatch repair give rise to hypermutability and the phenomenon called microsatellite instability. . …
It is involved in mitotic and meiotic recombination, apoptosis, immunoglobulin gene rearrangement, somatic hypermutation, and …
AID and somatic hypermutation.
Maul RW, Gearhart PJ. Maul RW, et al. Adv Immunol. 2010;105:159-91. doi: 10.1016/S0065-2776(10)05006-6. Adv Immunol. 2010. PMID: 20510733 Free PMC article. Review.
In response to an assault by foreign organisms, peripheral B cells can change their antibody affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify its DNA is exceptional in light of the potential consequences of genetic alterations …
In response to an assault by foreign organisms, peripheral B cells can change their antibody affinity and isotype by somatically muta …
Towards an understanding of somatic hypermutation.
Jacobs H, Bross L. Jacobs H, et al. Curr Opin Immunol. 2001 Apr;13(2):208-18. doi: 10.1016/s0952-7915(00)00206-5. Curr Opin Immunol. 2001. PMID: 11228415 Review.
How germinal center (GC) B cells diversify their rearranged immunoglobulin genes by somatic hypermutation is unknown. However, the GC-specific activation-induced cytidine deaminase has been identified as a key factor controlling two central GC-specific events: so …
How germinal center (GC) B cells diversify their rearranged immunoglobulin genes by somatic hypermutation is unknown. However, …
Targeting of somatic hypermutation.
Odegard VH, Schatz DG. Odegard VH, et al. Nat Rev Immunol. 2006 Aug;6(8):573-83. doi: 10.1038/nri1896. Nat Rev Immunol. 2006. PMID: 16868548 Review.
Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes at a rate of approximately 10(-3) mutations per base pair per cell division, which is 10(6)-fold higher than the spontaneous mutation rate in somatic cells. ...
Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes at a rate of approximately 10( …
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.
Elsner RA, Shlomchik MJ. Elsner RA, et al. Immunity. 2020 Dec 15;53(6):1136-1150. doi: 10.1016/j.immuni.2020.11.006. Immunity. 2020. PMID: 33326765 Free PMC article. Review.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF sites, followed by GC producing somatically mutated memory B cells (MBC) and long-lived plasma cells. However, somatic hypermutation (SHM) and affinity maturation can take …
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF sites, followed by GC producing somatically mu …
4,013 results