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Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
J Biol Chem. 2015 May 29;290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15.
J Biol Chem. 2015.
PMID: 25878251
Free PMC article.
Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.
Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S.
Sostegni S, et al.
Pflugers Arch. 2015 Apr;467(4):687-701. doi: 10.1007/s00424-014-1539-6. Epub 2014 Jun 8.
Pflugers Arch. 2015.
PMID: 24906497
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Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.
Zhao P, et al. Among authors: sostegni s.
J Biol Chem. 2014 Sep 26;289(39):27215-27234. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12.
J Biol Chem. 2014.
PMID: 25118282
Free PMC article.
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Erratum to: Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.
Sostegni S, Diakov A, McIntyre P, Bunnett N, Korbmacher C, Haerteis S.
Sostegni S, et al.
Pflugers Arch. 2017 Jun;469(5-6):845-846. doi: 10.1007/s00424-017-1973-3.
Pflugers Arch. 2017.
PMID: 28389775
No abstract available.
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Biocompatible cationic lipids for the formulation of liposomal DNA vectors.
Montis C, Sostegni S, Milani S, Baglioni P, Berti D.
Montis C, et al. Among authors: sostegni s.
Soft Matter. 2014 Jun 28;10(24):4287-97. doi: 10.1039/c4sm00142g.
Soft Matter. 2014.
PMID: 24788854
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A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain.
Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S.
Nativi C, et al. Among authors: sostegni s.
Sci Rep. 2013;3:2005. doi: 10.1038/srep02005.
Sci Rep. 2013.
PMID: 23774285
Free PMC article.
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