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Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW. Zhao P, et al. Among authors: sostegni s. J Biol Chem. 2014 Sep 26;289(39):27215-27234. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. J Biol Chem. 2014. PMID: 25118282 Free PMC article.
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain.
Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S. Nativi C, et al. Among authors: sostegni s. Sci Rep. 2013;3:2005. doi: 10.1038/srep02005. Sci Rep. 2013. PMID: 23774285 Free PMC article.