Southworth DR - Search Results

1

Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain.

Yokom AL, Morishima Y, Lau M, Su M, Glukhova A, Osawa Y, Southworth DR. Yokom AL, et al. Among authors: southworth dr. J Biol Chem. 2014 Jun 13;289(24):16855-65. doi: 10.1074/jbc.M114.564005. Epub 2014 Apr 15. J Biol Chem. 2014. PMID: 24737326 Free PMC article.

2

Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy.

Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR. Ewens CA, et al. Among authors: southworth dr. Structure. 2016 May 3;24(5):657-666. doi: 10.1016/j.str.2016.03.018. Epub 2016 Apr 21. Structure. 2016. PMID: 27112599 Free article.

3

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.

Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Yokom AL, et al. Among authors: southworth dr. Nat Struct Mol Biol. 2016 Sep;23(9):830-7. doi: 10.1038/nsmb.3277. Epub 2016 Aug 1. Nat Struct Mol Biol. 2016. PMID: 27478928 Free PMC article.

4

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Among authors: southworth dr. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.

5

Switch I-dependent allosteric signaling in a G-protein chaperone-B₁₂ enzyme complex.

Campanello GC, Lofgren M, Yokom AL, Southworth DR, Banerjee R. Campanello GC, et al. Among authors: southworth dr. J Biol Chem. 2017 Oct 27;292(43):17617-17625. doi: 10.1074/jbc.M117.786095. Epub 2017 Sep 7. J Biol Chem. 2017. PMID: 28882898 Free PMC article.

6

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. Cesa LC, et al. Among authors: southworth dr. J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18. J Biol Chem. 2018. PMID: 29255093 Free PMC article.

7

The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis.

Zhang H, Yokom AL, Cheng S, Su M, Hollenberg PF, Southworth DR, Osawa Y. Zhang H, et al. Among authors: southworth dr. J Biol Chem. 2018 May 18;293(20):7727-7736. doi: 10.1074/jbc.RA117.000600. Epub 2018 Apr 4. J Biol Chem. 2018. PMID: 29618513 Free PMC article.

8

Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.

Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Morishima Y, et al. Among authors: southworth dr. Mol Pharmacol. 2018 Sep;94(3):984-991. doi: 10.1124/mol.118.112516. Epub 2018 Jun 25. Mol Pharmacol. 2018. PMID: 29941666 Free PMC article.

9

Allosteric Regulation of Oligomerization by a B₁₂ Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria.

Ruetz M, Campanello GC, McDevitt L, Yokom AL, Yadav PK, Watkins D, Rosenblatt DS, Ohi MD, Southworth DR, Banerjee R. Ruetz M, et al. Among authors: southworth dr. Cell Chem Biol. 2019 Jul 18;26(7):960-969.e4. doi: 10.1016/j.chembiol.2019.03.014. Epub 2019 May 2. Cell Chem Biol. 2019. PMID: 31056463 Free PMC article.

10

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.

Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J. Tariq A, et al. Among authors: southworth dr. Cell Rep. 2019 Aug 20;28(8):2080-2095.e6. doi: 10.1016/j.celrep.2019.07.069. Cell Rep. 2019. PMID: 31433984 Free PMC article.

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