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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1971 1
1976 1
1977 1
1980 2
1981 1
1983 1
1984 7
1985 9
1986 4
1987 2
1988 4
1989 5
1990 6
1991 7
1992 6
1993 6
1994 3
1995 4
1996 5
1997 4
1998 6
1999 5
2000 5
2001 7
2002 10
2003 10
2004 19
2005 39
2006 48
2007 44
2008 51
2009 62
2010 57
2011 90
2012 91
2013 104
2014 106
2015 99
2016 129
2017 112
2018 108
2019 126
2020 103
2021 97
2022 88
2023 77
2024 30

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1,571 results

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Page 1
SP7: from Bone Development to Skeletal Disease.
Wang JS, Tokavanich N, Wein MN. Wang JS, et al. Curr Osteoporos Rep. 2023 Apr;21(2):241-252. doi: 10.1007/s11914-023-00778-7. Epub 2023 Mar 7. Curr Osteoporos Rep. 2023. PMID: 36881265 Free PMC article. Review.
RECENT FINDINGS: Cell-type and stage-specific functions of SP7 have been identified during bone formation and remodeling. Normal bone development regulated by SP7 is strongly associated with human bone health. ...SP7-associated signaling pathways, SP7- …
RECENT FINDINGS: Cell-type and stage-specific functions of SP7 have been identified during bone formation and remodeling. Normal bone …
Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases.
Hojo H, Ohba S. Hojo H, et al. Int J Mol Sci. 2022 May 18;23(10):5647. doi: 10.3390/ijms23105647. Int J Mol Sci. 2022. PMID: 35628456 Free PMC article. Review.
Following the identification of Sp7 and a large number of its functional studies, recent genome-scale analyses have made a major contribution to the identification of a "non-canonical" mode of Sp7 action as well as "canonical" ones. ...The critical role of SP7 …
Following the identification of Sp7 and a large number of its functional studies, recent genome-scale analyses have made a major cont …
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN. Wang JS, et al. Nat Commun. 2021 Nov 1;12(1):6271. doi: 10.1038/s41467-021-26571-7. Nat Commun. 2021. PMID: 34725346 Free PMC article.
Osteocrin is a Sp7 target gene that promotes osteocyte dendrite formation and rescues defects in Sp7-deficient mice. Single-cell RNA-sequencing demonstrates defects in osteocyte maturation in the absence of Sp7. Sp7-dependent osteocyte gene networks ar …
Osteocrin is a Sp7 target gene that promotes osteocyte dendrite formation and rescues defects in Sp7-deficient mice. Single-ce …
Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2.
Komori T. Komori T. Int J Mol Sci. 2019 Apr 4;20(7):1694. doi: 10.3390/ijms20071694. Int J Mol Sci. 2019. PMID: 30987410 Free PMC article. Review.
Runx2 regulates the proliferation of osteoblast progenitors and their differentiation into osteoblasts via reciprocal regulation with hedgehog, Fgf, Wnt, and Pthlh signaling molecules, and transcription factors, including Dlx5 and Sp7. Runx2 induces the expression of major …
Runx2 regulates the proliferation of osteoblast progenitors and their differentiation into osteoblasts via reciprocal regulation with hedgeh …
SP7 gene silencing dampens bone marrow stromal cell hypertrophy, but it also dampens chondrogenesis.
Franco RAG, McKenna E, Robey PG, Crawford RW, Doran MR, Futrega K. Franco RAG, et al. J Tissue Eng. 2023 Jun 21;14:20417314231177136. doi: 10.1177/20417314231177136. eCollection 2023 Jan-Dec. J Tissue Eng. 2023. PMID: 37362901 Free PMC article.
Herein, we stably transduced BMSCs to express an shRNA designed to silence SP7, and assess the capacity of SP7 silencing to mitigate hypertrophy. ...We further investigated the role of SP7 in monolayer osteogenic and adipogenic cultures, finding that SP7 …
Herein, we stably transduced BMSCs to express an shRNA designed to silence SP7, and assess the capacity of SP7 silencing to mi …
Runx2, an inducer of osteoblast and chondrocyte differentiation.
Komori T. Komori T. Histochem Cell Biol. 2018 Apr;149(4):313-323. doi: 10.1007/s00418-018-1640-6. Epub 2018 Jan 22. Histochem Cell Biol. 2018. PMID: 29356961 Review.
Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for the specification of Runx2(+) osteoprogenitors in endochondral bone development. Runx2 induces Sp7, an essential transcription factor for osteoblast differentiation. ...Runx2(+) osteoprogenito …
Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for the specification of Runx2(+) osteoprogenitors in endochond …
SP7 inhibits osteoblast differentiation at a late stage in mice.
Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T. Yoshida CA, et al. PLoS One. 2012;7(3):e32364. doi: 10.1371/journal.pone.0032364. Epub 2012 Mar 2. PLoS One. 2012. PMID: 22396760 Free PMC article.
The expression of Sp7 and Runx2 was not increased in Runx2 and Sp7 transgenic mice, respectively. The expression of endogenous Sp7 was increased in Sp7 transgenic mice and Sp7-transduced cells; the introduction of Sp7 activated and sh- …
The expression of Sp7 and Runx2 was not increased in Runx2 and Sp7 transgenic mice, respectively. The expression of endogenous …
Klf4 haploinsufficiency in Sp7+ lineage leads to underdeveloped mandibles and insufficient elongation of mandibular incisor.
Guo J, Yu S, Zhang H, Zhang L, Yuan G, Liu H, Chen Z. Guo J, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Mar;1869(3):166636. doi: 10.1016/j.bbadis.2022.166636. Epub 2022 Dec 28. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 36584722 Free article.
Previously, we demonstrated that Kruppel-like factor 4 (KLF4) promoted dentinogenesis and osteogenesis, but it was enigmatic whether Klf4 participated in the development of the mandible. In this study, the Sp7-Cre; Klf4(f/+) mice exhibited underdeveloped mandibles and insu …
Previously, we demonstrated that Kruppel-like factor 4 (KLF4) promoted dentinogenesis and osteogenesis, but it was enigmatic whether Klf4 pa …
Sp7 Transgenic Mice with a Markedly Impaired Lacunocanalicular Network Induced Sost and Reduced Bone Mass by Unloading.
Moriishi T, Ito T, Fukuyama R, Qin X, Komori H, Kaneko H, Matsuo Y, Yoshida N, Komori T. Moriishi T, et al. Int J Mol Sci. 2022 Mar 15;23(6):3173. doi: 10.3390/ijms23063173. Int J Mol Sci. 2022. PMID: 35328592 Free PMC article.
However, these differential responses were lost in the Sp7 transgenic femurs. Serum Sost increased in the Sp7 transgenic mice, but not in the wild-type mice. Unloading reduced the Col1a1 and Bglap/Bglap2 expression in the Sp7 transgenic mice but not the wild- …
However, these differential responses were lost in the Sp7 transgenic femurs. Serum Sost increased in the Sp7 transgenic mice, …
Serine protease SP7 cleaves prophenoloxidase and is regulated by two serpins in Ostrinia furnacalis melanization.
Zhang S, Feng T, Ji J, Wang L, An C. Zhang S, et al. Insect Biochem Mol Biol. 2022 Feb;141:103699. doi: 10.1016/j.ibmb.2021.103699. Epub 2021 Dec 14. Insect Biochem Mol Biol. 2022. PMID: 34920078
Recombinant SP7 zymogen was activated by serine protease SP2. The active SP7 could cleave O. furnacalis PPOs including PPO2, PPO1b and PPO3. ...Our work thus revealed that SP7 and SP2 partially constituted a PPO activation cascade in which SP7 was acti …
Recombinant SP7 zymogen was activated by serine protease SP2. The active SP7 could cleave O. furnacalis PPOs including PPO2, P …
1,571 results