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Page 1
Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2.
Liu B, Xiang L, Ji J, Liu W, Chen Y, Xia M, Liu Y, Liu W, Zhu P, Jin Y, Han Y, Lu J, Li X, Zheng M, Lu Y. Liu B, et al. J Clin Invest. 2021 Oct 15;131(20):e144801. doi: 10.1172/JCI144801. J Clin Invest. 2021. PMID: 34651580 Free PMC article.
Functional studies showed that both chronic injection of recombinant Sparcl1 protein and overexpression of Sparcl1 exaggerated hepatic inflammation and liver injury in mice. In contrast, genetic ablation of Sparcl1, knockdown of Sparcl1 in WAT, and tre …
Functional studies showed that both chronic injection of recombinant Sparcl1 protein and overexpression of Sparcl1 exaggerated …
Sparcl1 and Atherosclerosis.
Cheng X, Chen X, Zhang M, Wan Y, Ge S, Cheng X. Cheng X, et al. J Inflamm Res. 2023 May 17;16:2121-2127. doi: 10.2147/JIR.S406907. eCollection 2023. J Inflamm Res. 2023. PMID: 37220502 Free PMC article. Review.
SPARCL1 a novel player in cancer biology.
Gagliardi F, Narayanan A, Mortini P. Gagliardi F, et al. Crit Rev Oncol Hematol. 2017 Jan;109:63-68. doi: 10.1016/j.critrevonc.2016.11.013. Epub 2016 Nov 24. Crit Rev Oncol Hematol. 2017. PMID: 28010899 Review.
They include several, structurally unrelated, members and their homologs. Among these a particularly interesting one is SPARCL1 due to its potential interactions in tumor biology. SPARCL1 is a secreted glycoprotein, belonging to SPARC family of matricellular protein …
They include several, structurally unrelated, members and their homologs. Among these a particularly interesting one is SPARCL1 due t …
SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal Cancer.
Zhang HP, Wu J, Liu ZF, Gao JW, Li SY. Zhang HP, et al. Biomed Res Int. 2022 Jan 24;2022:1398268. doi: 10.1155/2022/1398268. eCollection 2022. Biomed Res Int. 2022. PMID: 35111844 Free PMC article.
Then, comprehensive database search was conducted for published clinical studies to explore clinical significance of SPARCL1. In addition, coexpression genes of SPARCL1 were identified through the cBioPortal database and enrichment analysis of SPARCL1 and its …
Then, comprehensive database search was conducted for published clinical studies to explore clinical significance of SPARCL1. In addi …
Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
Chen G, Xu J, Luo H, Luo X, Singh SK, Ramirez JJ, James ML, Mathew JP, Berger M, Eroglu C, Ji RR. Chen G, et al. JCI Insight. 2022 Dec 8;7(23):e161028. doi: 10.1172/jci.insight.161028. JCI Insight. 2022. PMID: 36256481 Free PMC article.
High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. ...Finally, neurosurgery caused rapid and substantial increases in SPARCL1/HEVIN levels in human CSF. Collectively, our findi …
High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the …
Effects of SPARCL1 on the proliferation and differentiation of sheep preadipocytes.
Xiao C, Jin HG, Zhang LC, Liu JQ, He M, Ma HH, Yu YS, Cao Y. Xiao C, et al. Adipocyte. 2021 Dec;10(1):658-669. doi: 10.1080/21623945.2021.2010901. Adipocyte. 2021. PMID: 34872433 Free PMC article.
However, the role of the SPARCL1 gene in sheep preadipocytes and its regulatory mechanism is still unclear. In this study, we explored the effect of SPARCL1 on the proliferation and differentiation of sheep preadipocytes. ...
However, the role of the SPARCL1 gene in sheep preadipocytes and its regulatory mechanism is still unclear. In this study, we explore …
Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation.
Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Zhao G, et al. bioRxiv [Preprint]. 2023 May 25:2023.05.25.541966. doi: 10.1101/2023.05.25.541966. bioRxiv. 2023. PMID: 37292817 Free PMC article. Preprint.
Mechanistically, SPARCL1 acts directly on macrophages in vitro to induce the pro-inflammatory phenotype via activation of TLR4, and TLR4 inhibition in vivo ameliorates inflammatory exacerbations caused by endothelial Sparcl1 overexpression. ...Survival analysis demo …
Mechanistically, SPARCL1 acts directly on macrophages in vitro to induce the pro-inflammatory phenotype via activation of TLR4, and T …
SPARCL1 exhibits different expressions in left- and right-sided colon cancer and is downregulated via DNA methylation.
Hu H, Wu D, Liu X, Yu H, Xu J, Cai W, Huang Y, Bai R, Zhang J, Gu Y, Zheng S, Ge W. Hu H, et al. Epigenomics. 2021 Aug;13(16):1269-1282. doi: 10.2217/epi-2021-0231. Epub 2021 Aug 26. Epigenomics. 2021. PMID: 34435512
Aim: The authors previously found that SPARCL1 functions to suppress colorectal cancer metastasis. Here, the epigenetic mechanism of SPARCL1 regulation and its relationship with clinicopathological features in colon cancer were investigated. ...Further in-depth stud …
Aim: The authors previously found that SPARCL1 functions to suppress colorectal cancer metastasis. Here, the epigenetic mechanism of …
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Gan KJ, Südhof TC. Gan KJ, et al. J Neurosci. 2020 Oct 14;40(42):8088-8102. doi: 10.1523/JNEUROSCI.0454-20.2020. Epub 2020 Sep 24. J Neurosci. 2020. PMID: 32973045 Free PMC article.
None of these effects were mediated by SPARCL1-binding to neurexins or neuroligins. Neurons from triple neurexin-1/2/3 or from quadruple neuroligin-1/2/3/4 conditional KO mice that lacked all neurexins or all neuroligins were fully responsive to SPARCL1. ...Here, we …
None of these effects were mediated by SPARCL1-binding to neurexins or neuroligins. Neurons from triple neurexin-1/2/3 or from quadru …
Immunological role and prognostic value of SPARCL1 in pan-cancer analysis.
He K, Li C, Yuan H, Jiang K, Deng G. He K, et al. Pathol Oncol Res. 2022 Nov 22;28:1610687. doi: 10.3389/pore.2022.1610687. eCollection 2022. Pathol Oncol Res. 2022. PMID: 36483097 Free PMC article.
Background: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) was a kind of extracellular matrix glycoprotein. SPARCL1 was strongly inhibited in most cancers. ...Although SPARCL1 was down-regulated in most cancers, SPARCL1 might play a prot …
Background: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) was a kind of extracellular matrix glycoprotein. SPARCL1 …
235 results