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Identification of nonfunctional SPATA20 causing acephalic spermatozoa syndrome in humans.
Wang X, Jiang C, Dai S, Shen G, Yang Y, Shen Y. Wang X, et al. Clin Genet. 2023 Mar;103(3):310-319. doi: 10.1111/cge.14268. Epub 2022 Nov 30. Clin Genet. 2023. PMID: 36415156
However, knowledge about the causative genes associated with ASS in humans is limited. Loss-of-function of SPATA20 has been suggested to result in the separation of the sperm head and flagellum in mice, whereas there have been no cases reporting SPATA20 variants lea …
However, knowledge about the causative genes associated with ASS in humans is limited. Loss-of-function of SPATA20 has been suggested …
SPATA20 deficiency enhances the metastatic and angiogenic potential of cancer cells by promoting HIF-1alpha synthesis.
Choi S, Yoo S, Jeon M, Park S, Choi Y, An J, Jeon S, Lee M, Yun JH, Park JW, Kim I. Choi S, et al. Am J Cancer Res. 2024 Feb 15;14(2):727-743. doi: 10.62347/EHQK4921. eCollection 2024. Am J Cancer Res. 2024. PMID: 38455399 Free PMC article.
Depleting SPATA20 induced HIF-1alpha expression, suggesting a tumor-suppressive role for SPATA20 in cancer cells. SPATA20 depletion increased HIF-1alpha protein levels and transcriptional activity without affecting its degradation. ...
Depleting SPATA20 induced HIF-1alpha expression, suggesting a tumor-suppressive role for SPATA20 in cancer cells. SPATA20 …
Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer.
Fernández-Rozadilla C, Álvarez-Barona M, Quintana I, López-Novo A, Amigo J, Cameselle-Teijeiro JM, Roman E, Gonzalez D, Llor X, Bujanda L, Bessa X, Jover R, Balaguer F, Castells A, Castellví-Bel S, Capellá G, Carracedo A, Valle L, Ruiz-Ponte C. Fernández-Rozadilla C, et al. Sci Rep. 2021 May 27;11(1):11135. doi: 10.1038/s41598-021-90590-z. Sci Rep. 2021. PMID: 34045552 Free PMC article.
In this study, we sequenced 20 early-onset CRC patients to discover novel genetic variants that could be linked to the prompt disease development. Eight genes, CHAD, CHD1L, ERCC6, IGTB7, PTPN13, SPATA20, TDG and TGS1, were selected and re-sequenced in a further 304 early o …
In this study, we sequenced 20 early-onset CRC patients to discover novel genetic variants that could be linked to the prompt disease develo …
Regional fat depot masses are influenced by protein-coding gene variants.
Neville MJ, Wittemans LBL, Pinnick KE, Todorčević M, Kaksonen R, Pietiläinen KH, Luan J, Scott RA, Wareham NJ, Langenberg C, Karpe F. Neville MJ, et al. PLoS One. 2019 May 30;14(5):e0217644. doi: 10.1371/journal.pone.0217644. eCollection 2019. PLoS One. 2019. PMID: 31145760 Free PMC article.
The minor allele-carrying transcript of CCDC92 is constitutively more highly expressed in adipose tissue samples. In addition, we identify two coding variants in SPATA20 and UQCC1 that are associated with arm fat mass. SPATA20K422R is a low-frequency variant with a large e …
The minor allele-carrying transcript of CCDC92 is constitutively more highly expressed in adipose tissue samples. In addition, we identify t …
Characterization of MicroRNAs Associated with Reproduction in the Brown Planthopper, Nilaparvata lugens.
Wang N, Zhang C, Chen M, Shi Z, Zhou Y, Shi X, Zhou W, Zhu Z. Wang N, et al. Int J Mol Sci. 2022 Jul 15;23(14):7808. doi: 10.3390/ijms23147808. Int J Mol Sci. 2022. PMID: 35887156 Free PMC article.
Moreover, target genes prediction for miR-34-5p showed they might be involved in 20E signaling cascades, apoptosis, and gonadal development, including hormone receptor 4 (HR4), caspase-1 (Cp-1), and spermatogenesis-associated protein 20 (SPATA20). These findings provide a …
Moreover, target genes prediction for miR-34-5p showed they might be involved in 20E signaling cascades, apoptosis, and gonadal development, …
Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility.
Omolaoye TS, Hachim MY, du Plessis SS. Omolaoye TS, et al. Sci Rep. 2022 Feb 16;12(1):2584. doi: 10.1038/s41598-022-06476-1. Sci Rep. 2022. PMID: 35173218 Free PMC article.
Twenty-five DEGs were shared between most of the datasets, which might indicate their role in the pathogenesis of male infertility. Of the 25 DEGs, eight genes (THEG, SPATA20, ROPN1L, GSTF1, TSSK1B, CABS1, ADAD1, RIMBP3) are either involved in the overall spermatogenic pro …
Twenty-five DEGs were shared between most of the datasets, which might indicate their role in the pathogenesis of male infertility. Of the 2 …
Differentially expressed genes in the testes from early to mature development of banana shrimp (Fenneropenaeus merguiensis).
Saetan U, Chotigeat W. Saetan U, et al. PLoS One. 2023 Oct 9;18(10):e0292127. doi: 10.1371/journal.pone.0292127. eCollection 2023. PLoS One. 2023. PMID: 37812598 Free PMC article.
Some of these genes were designated as candidate genes, and six specific DEGs, including PRM1, SPATA20, Sry, SSRF, Sxl, and Tra-2c, were selected to confirm the reliability of the RNA-seq data using qPCR. Moreover, six non-DEGs were chosen based on testis-specific and regu …
Some of these genes were designated as candidate genes, and six specific DEGs, including PRM1, SPATA20, Sry, SSRF, Sxl, and Tra-2c, w …
Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men.
Zheng H, Zhou X, Li DK, Yang F, Pan H, Li T, Miao M, Li R, Yuan W. Zheng H, et al. PLoS One. 2017 Jun 5;12(6):e0178535. doi: 10.1371/journal.pone.0178535. eCollection 2017. PLoS One. 2017. PMID: 28582417 Free PMC article.
Some of the BPA-affected genes, for example, MLH1, CHD2, SPATA12 and SPATA20 might participate in the response to DNA damage in germ cells caused by BPA. ...
Some of the BPA-affected genes, for example, MLH1, CHD2, SPATA12 and SPATA20 might participate in the response to DNA damage in germ …
Comparative proteomic profiling of human bile reveals SSP411 as a novel biomarker of cholangiocarcinoma.
Shen J, Wang W, Wu J, Feng B, Chen W, Wang M, Tang J, Wang F, Cheng F, Pu L, Tang Q, Wang X, Li X. Shen J, et al. PLoS One. 2012;7(10):e47476. doi: 10.1371/journal.pone.0047476. Epub 2012 Oct 31. PLoS One. 2012. PMID: 23118872 Free PMC article.
Immunohistochemistry was performed to determine the expression levels of selected candidate biomarkers in CC and matched normal tissues. Finally, spermatogenesis associated 20 (SSP411; also named SPATA20) was quantified in serum samples using an ELISA. RESULTS: We identifi …
Immunohistochemistry was performed to determine the expression levels of selected candidate biomarkers in CC and matched normal tissues. Fin …
12 results