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Year Number of Results
2003 2
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2005 2
2007 5
2008 4
2009 3
2010 2
2012 3
2013 2
2014 2
2015 1
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2018 5
2019 4
2020 7
2021 4
2022 3
2023 2
2024 0

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49 results

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Page 1
SPINK7 Recognizes Fungi and Initiates Hemocyte-Mediated Immune Defense Against Fungal Infections.
Dong Z, An L, Lu M, Tang M, Chen H, Huang X, Hou Y, Shen G, Zhang X, Zhang Y, Xia Q, Zhao P. Dong Z, et al. Front Immunol. 2021 Sep 17;12:735497. doi: 10.3389/fimmu.2021.735497. eCollection 2021. Front Immunol. 2021. PMID: 34603317 Free PMC article.
Enzyme activity inhibition test showed that SPINK7 significantly inhibited the activity of proteinase K from C. albicans. ...In vitro assays were performed using SPINK7-coated agarose beads, and indicated that SPINK7 promoted encapsulation and melanization of …
Enzyme activity inhibition test showed that SPINK7 significantly inhibited the activity of proteinase K from C. albicans. ...In vitro …
Neutrophils-derived Spink7 as one safeguard against experimental murine colitis.
Zhao N, Wang G, Long S, Liu D, Gao J, Xu Y, Wang C, Wang A, Wang F, Hao Y, Ran X, Wang J, Su Y, Wang T. Zhao N, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166125. doi: 10.1016/j.bbadis.2021.166125. Epub 2021 Mar 13. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33722746 Free article.
Here, we describe an endogenous, homeostatic pattern that controls inflammatory responses in experimental murine colitis. We show that Spink7 (serine peptidase inhibitor, kazal type 7), the ortholog of human SPINK7, is significantly upregulated in dextran sodium sul …
Here, we describe an endogenous, homeostatic pattern that controls inflammatory responses in experimental murine colitis. We show that Sp …
SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level.
Pennacchiotti G, Valdés-Gutiérrez F, González-Arriagada WA, Montes HF, Parra JMR, Guida VA, Gómez SE, Guerrero-Gimenez ME, Fernandez-Muñoz JM, Zoppino FCM, Carón RW, Ezquer ME, Fernández-Ramires R, Bruna FA. Pennacchiotti G, et al. Sci Rep. 2021 Mar 25;11(1):6939. doi: 10.1038/s41598-021-86208-z. Sci Rep. 2021. PMID: 33767253 Free PMC article.
Also, SPINK7, HER2, TP53, and RB1, were evaluated by immunohistofluorescence. ...SPINK7 had also diminished in TCGA patients (p = 2.10e-6). In less invasive OSCC, SPINK7 and HER2 proteins had decreased while TP53 and RB1 had increased with respect to the othe …
Also, SPINK7, HER2, TP53, and RB1, were evaluated by immunohistofluorescence. ...SPINK7 had also diminished in TCGA patients ( …
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses.
Azouz NP, Ynga-Durand MA, Caldwell JM, Jain A, Rochman M, Fischesser DM, Ray LM, Bedard MC, Mingler MK, Forney C, Eilerman M, Kuhl JT, He H, Biagini Myers JM, Mukkada VA, Putnam PE, Khurana Hershey GK, Kottyan LC, Wen T, Martin LJ, Rothenberg ME. Azouz NP, et al. Sci Transl Med. 2018 Jun 6;10(444):eaap9736. doi: 10.1126/scitranslmed.aap9736. Sci Transl Med. 2018. PMID: 29875205 Free PMC article.
Epithelial silencing of SPINK7 promoted production of proinflammatory cytokines including thymic stromal lymphopoietin (TSLP). Loss of SPINK7 increased the activity of urokinase plasminogen-type activator (uPA), which in turn had the capacity to promote uPA receptor …
Epithelial silencing of SPINK7 promoted production of proinflammatory cytokines including thymic stromal lymphopoietin (TSLP). Loss o …
Epithelial origin of eosinophilic esophagitis.
Rochman M, Azouz NP, Rothenberg ME. Rochman M, et al. J Allergy Clin Immunol. 2018 Jul;142(1):10-23. doi: 10.1016/j.jaci.2018.05.008. J Allergy Clin Immunol. 2018. PMID: 29980278 Free PMC article. Review.
Among these pathways, basal production of the serine protease inhibitor, Kazal-type 7 (SPINK7) has been demonstrated to be part of the normal differentiation program of esophageal epithelium. Profound lost expression of SPINK7 occurs in patients with EoE and is suff …
Among these pathways, basal production of the serine protease inhibitor, Kazal-type 7 (SPINK7) has been demonstrated to be part of th …
The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed in human skin.
Weber C, Fischer J, Redelfs L, Rademacher F, Harder J, Weidinger S, Wu Z, Meyer-Hoffert U. Weber C, et al. Arch Dermatol Res. 2017 Nov;309(9):767-771. doi: 10.1007/s00403-017-1773-9. Epub 2017 Aug 29. Arch Dermatol Res. 2017. PMID: 28852849
In cultured keratinocytes, SPINK7 mRNA expression was up-regulated by IL-17A together with IFNgamma. Our observation points to a role of SPINK7 in skin homeostasis and its involvement in inflammatory skin diseases....
In cultured keratinocytes, SPINK7 mRNA expression was up-regulated by IL-17A together with IFNgamma. Our observation points to a role …
Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis.
Lyles J, Rothenberg M. Lyles J, et al. Curr Opin Immunol. 2019 Oct;60:46-53. doi: 10.1016/j.coi.2019.04.004. Epub 2019 May 25. Curr Opin Immunol. 2019. PMID: 31132551 Free PMC article. Review.
Identified genetic variants in FLG, DSG1, CAPN14, SPINK5, and SPINK7 link EoE to epithelial barrier dysfunction, whereas variants in CCL26, POSTN, and TSLP associate EoE with T helper type 2-mediated immunity. ...
Identified genetic variants in FLG, DSG1, CAPN14, SPINK5, and SPINK7 link EoE to epithelial barrier dysfunction, whereas variants in …
Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.
Azouz NP, Klingler AM, Pathre P, Besse JA, Baruch-Morgenstern NB, Ballaban AY, Osswald GA, Brusilovsky M, Habel JE, Caldwell JM, Ynga-Durand MA, Abonia PJ, Hu YC, Wen T, Rothenberg ME. Azouz NP, et al. Sci Transl Med. 2020 May 27;12(545):eaaz7773. doi: 10.1126/scitranslmed.aaz7773. Sci Transl Med. 2020. PMID: 32461336 Free PMC article.
Evidence is emerging that loss of esophageal expression of the serine peptidase inhibitor, kazal type 7 (SPINK7), is an upstream event in EoE pathogenesis. Here, we provide evidence that loss of SPINK7 mediates its pro-EoE effects via kallikrein 5 (KLK5) and its sub …
Evidence is emerging that loss of esophageal expression of the serine peptidase inhibitor, kazal type 7 (SPINK7), is an upstream even …
Esophageal Mucosal Permeability as a Surrogate Measure of Cure in Eosinophilic Esophagitis.
Chen J, Oshima T, Huang X, Tomita T, Fukui H, Miwa H. Chen J, et al. J Clin Med. 2022 Jul 21;11(14):4246. doi: 10.3390/jcm11144246. J Clin Med. 2022. PMID: 35888006 Free PMC article.
Levels of interleukin-13, calpain-14, and eotaxin-3 mRNAs were significantly upregulated, while filaggrin, serine peptidase inhibitor Kazal type 7 (SPINK7), and involucrin mRNAs were significantly downregulated in EoE patients. In patients achieving histologic remission di …
Levels of interleukin-13, calpain-14, and eotaxin-3 mRNAs were significantly upregulated, while filaggrin, serine peptidase inhibitor Kazal …
Comprehensive bioinformatics analysis identifies lncRNA HCG22 as a migration inhibitor in esophageal squamous cell carcinoma.
Li X, Xiao X, Chang R, Zhang C. Li X, et al. J Cell Biochem. 2020 Jan;121(1):468-481. doi: 10.1002/jcb.29218. Epub 2019 Jun 25. J Cell Biochem. 2020. PMID: 31236983
The lncRNA-mRNA regulatory network showed the coexpression association between lncRNA HCG22 and SPINK7 and ADAMTS12. GO and KEGG analyses showed that HCG22 and ADAMTS12 had potential biological functions in the cell migration of ESCC. ...In conclusion, lncRNA HCG22 was dow …
The lncRNA-mRNA regulatory network showed the coexpression association between lncRNA HCG22 and SPINK7 and ADAMTS12. GO and KEGG anal …
49 results