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Nrf2 is a critical modulator of the innate immune response in a model of uveitis.
Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT. Nagai N, et al. Among authors: sporn mb. Free Radic Biol Med. 2009 Aug 1;47(3):300-6. doi: 10.1016/j.freeradbiomed.2009.04.033. Epub 2009 May 3. Free Radic Biol Med. 2009. PMID: 19410644 Free PMC article.
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Thimmulappa RK, et al. Among authors: sporn mb. Antioxid Redox Signal. 2007 Nov;9(11):1963-70. doi: 10.1089/ars.2007.1745. Antioxid Redox Signal. 2007. PMID: 17822364 Free PMC article.
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S. Sussan TE, et al. Among authors: sporn mb. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. doi: 10.1073/pnas.0804333106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2009. PMID: 19104057 Free PMC article.
Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.
Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ. Xu Z, et al. Among authors: sporn mb. J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064. Epub 2015 Mar 4. J Neurochem. 2015. PMID: 25683606 Free PMC article.
510 results