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2001 1
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2010 6
2011 4
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2013 5
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118 results

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Page 1
SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype.
Motta M, Fasano G, Gredy S, Brinkmann J, Bonnard AA, Simsek-Kiper PO, Gulec EY, Essaddam L, Utine GE, Guarnetti Prandi I, Venditti M, Pantaleoni F, Radio FC, Ciolfi A, Petrini S, Consoli F, Vignal C, Hepbasli D, Ullrich M, de Boer E, Vissers LELM, Gritli S, Rossi C, De Luca A, Ben Becher S, Gelb BD, Dallapiccola B, Lauri A, Chillemi G, Schuh K, Cavé H, Zenker M, Tartaglia M. Motta M, et al. Am J Hum Genet. 2021 Nov 4;108(11):2112-2129. doi: 10.1016/j.ajhg.2021.09.007. Epub 2021 Oct 8. Am J Hum Genet. 2021. PMID: 34626534 Free PMC article.
Pathogenic variants in more than 20 genes have been causally linked to RASopathies, the majority having a dominant role in promoting enhanced signaling. Here, we report that SPRED2 loss of function is causally linked to a recessive phenotype evocative of Noonan syndrome. . …
Pathogenic variants in more than 20 genes have been causally linked to RASopathies, the majority having a dominant role in promoting enhance …
Spred2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by impairing ERK signaling.
Wang H, Liu S, Kong F, Xiao F, Li Y, Wang H, Zhang S, Huang D, Wang L, Yang Y. Wang H, et al. Oncol Rep. 2020 Jul;44(1):174-184. doi: 10.3892/or.2020.7586. Epub 2020 Apr 16. Oncol Rep. 2020. PMID: 32319644 Free PMC article.
To restore Spred2 levels, Ad.Spred2, an adenoviral vector expressing Spred2, was transduced into CRC cells. ...However, neither Ad.Spred2 nor PD98059 had an obvious effect on the expression of SMAD2/3 or SMAD4 in SW480 cells, indicating that Ad.Spre …
To restore Spred2 levels, Ad.Spred2, an adenoviral vector expressing Spred2, was transduced into CRC cells. ...However, …
Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4(+) and CD8(+) T cells.
Sun C, Fujisawa M, Ohara T, Liu Q, Cao C, Yang X, Yoshimura T, Kunkel SL, Matsukawa A. Sun C, et al. J Adv Res. 2021 Apr 20;35:71-86. doi: 10.1016/j.jare.2021.03.014. eCollection 2022 Jan. J Adv Res. 2021. PMID: 35003795 Free PMC article.
Hepatic ERK phosphorylation was enhanced in Spred2(-/-) mice, and pretreatment of Spred2(-/-) mice with the MAPK/ERK inhibitor U0126 markedly inhibited the liver damage and reduced IFNgamma production. ...CONCLUSION: We demonstrated, for the first time, that Spre …
Hepatic ERK phosphorylation was enhanced in Spred2(-/-) mice, and pretreatment of Spred2(-/-) mice with the MAPK/ERK inhibitor …
SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.
Ullrich M, Aßmus B, Augustin AM, Häbich H, Abeßer M, Martin Machado J, Werner F, Erkens R, Arias-Loza AP, Umbenhauer S, Wagner H, Benz PM, Unger A, Linke WA, Frantz S, Baba HA, Kuhn M, Schuh K. Ullrich M, et al. J Mol Cell Cardiol. 2019 Apr;129:13-26. doi: 10.1016/j.yjmcc.2019.01.023. Epub 2019 Feb 13. J Mol Cell Cardiol. 2019. PMID: 30771306
SPRED2(-/-) mice showed cardiomyocyte hypertrophy, cardiac fibrosis, impaired electrical excitability, and severe arrhythmias. ...Furthermore, the autophagosomal adaptors p62/SQSTM1 and NBR1 and lysosomal Cathepsin D accumulated in SPRED2(-/-) hearts. In wild-type h …
SPRED2(-/-) mice showed cardiomyocyte hypertrophy, cardiac fibrosis, impaired electrical excitability, and severe arrhythmias. ...Fur …
Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
Kawara A, Mizuta R, Fujisawa M, Ito T, Li C, Nakamura K, Sun C, Kuwabara M, Kitabatake M, Yoshimura T, Matsukawa A. Kawara A, et al. Sci Rep. 2020 Oct 5;10(1):16490. doi: 10.1038/s41598-020-73752-3. Sci Rep. 2020. PMID: 33020583 Free PMC article.
Spred2(-/-) lung epithelial cells or MLE-12 cells treated with spred2 siRNA proliferated faster than control cells in vitro. ...Thus, Spred2 may present a new therapeutic target for the treatment of PF....
Spred2(-/-) lung epithelial cells or MLE-12 cells treated with spred2 siRNA proliferated faster than control cells in vitro. . …
SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells.
Gao T, Yang X, Fujisawa M, Ohara T, Wang T, Tomonobu N, Sakaguchi M, Yoshimura T, Matsukawa A. Gao T, et al. Int J Mol Sci. 2023 Mar 5;24(5):4996. doi: 10.3390/ijms24054996. Int J Mol Sci. 2023. PMID: 36902429 Free PMC article.
Here, we investigated the effects of SPRED2 loss on hepatocellular carcinoma (HCC) cell function. Human HCC cell lines, expressing various levels of SPRED2 and SPRED2 knockdown, increased ERK1/2 activation. ...Interestingly, SPRED2-KO cells also expres …
Here, we investigated the effects of SPRED2 loss on hepatocellular carcinoma (HCC) cell function. Human HCC cell lines, expressing va …
Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder.
Oda S, Fujisawa M, Chunning L, Ito T, Yamaguchi T, Yoshimura T, Matsukawa A. Oda S, et al. PLoS One. 2021 Nov 24;16(11):e0254289. doi: 10.1371/journal.pone.0254289. eCollection 2021. PLoS One. 2021. PMID: 34818323 Free PMC article.
HGPUC with membranous Spred2 expression correlated significantly with lower levels of ERK activation and Ki67 index as compared to those with negative Spred2 expression. ...Spred2 appears to be a key regulator in the progression of non-invasive bladder carcin …
HGPUC with membranous Spred2 expression correlated significantly with lower levels of ERK activation and Ki67 index as compared to th …
Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice.
Ohkura T, Yoshimura T, Fujisawa M, Ohara T, Marutani R, Usami K, Matsukawa A. Ohkura T, et al. Front Immunol. 2019 Jan 22;10:17. doi: 10.3389/fimmu.2019.00017. eCollection 2019. Front Immunol. 2019. PMID: 30723473 Free PMC article.
The number of infiltrating macrophages with a M1 phenotype, and the crown-like structures, composed of macrophages surrounding dead or dying adipocytes, were more abundant in Spred2 KO-mWAT compared to in WT-mWAT. Exacerbated adipose tissue inflammation in Spred2 KO …
The number of infiltrating macrophages with a M1 phenotype, and the crown-like structures, composed of macrophages surrounding dead or dying …
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Yin H, Zhang X, Yang P, Zhang X, Peng Y, Li D, Yu Y, Wu Y, Wang Y, Zhang J, Ding X, Wang X, Yang A, Zhang R. Yin H, et al. Nat Commun. 2021 Mar 2;12(1):1394. doi: 10.1038/s41467-021-21514-8. Nat Commun. 2021. PMID: 33654093 Free PMC article.
In contrast to wild-type mice, Mettl3-deficient mice show increased M1/M2-like tumour-associated macrophage and regulatory T cell infiltration into tumours. m6A sequencing reveals that loss of METTL3 impairs the YTHDF1-mediated translation of SPRED2, which enhances the act …
In contrast to wild-type mice, Mettl3-deficient mice show increased M1/M2-like tumour-associated macrophage and regulatory T cell infiltrati …
SPRED2 promotes autophagy and attenuates inflammatory response in IL-1beta induced osteoarthritis chondrocytes via regulating the p38 MAPK signaling pathway.
Wei J, You G, Cheng H, Gao C. Wei J, et al. Tissue Cell. 2023 Jun;82:102086. doi: 10.1016/j.tice.2023.102086. Epub 2023 Apr 1. Tissue Cell. 2023. PMID: 37058811
SPRED2 enhanced chondrocyte proliferation and prevented cell apoptosis induced by IL-1beta. SPRED2 prevented IL-1beta-induced chondrocytes autophagy and inflammatory response in chondrocytes. ...
SPRED2 enhanced chondrocyte proliferation and prevented cell apoptosis induced by IL-1beta. SPRED2 prevented IL-1beta-induced …
118 results