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Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.
Stoermer D, Vitharana D, Hin N, Delahanty G, Duvall B, Ferraris DV, Grella BS, Hoover R, Rojas C, Shanholtz MK, Smith KP, Stathis M, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T. Stoermer D, et al. Among authors: stathis m. J Med Chem. 2012 Jun 28;55(12):5922-32. doi: 10.1021/jm300488m. Epub 2012 Jun 12. J Med Chem. 2012. PMID: 22642259
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T. Shukla K, et al. Among authors: stathis m. J Med Chem. 2012 Dec 13;55(23):10551-63. doi: 10.1021/jm301191p. Epub 2012 Nov 30. J Med Chem. 2012. PMID: 23151085 Free PMC article.
Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.
Rahn KA, Watkins CC, Alt J, Rais R, Stathis M, Grishkan I, Crainiceau CM, Pomper MG, Rojas C, Pletnikov MV, Calabresi PA, Brandt J, Barker PB, Slusher BS, Kaplin AI. Rahn KA, et al. Among authors: stathis m. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20101-6. doi: 10.1073/pnas.1209934109. Epub 2012 Nov 19. Proc Natl Acad Sci U S A. 2012. PMID: 23169655 Free PMC article.
45 results