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Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.
Winblad B, Andreasen N, Minthon L, Floesser A, Imbert G, Dumortier T, Maguire RP, Blennow K, Lundmark J, Staufenbiel M, Orgogozo JM, Graf A. Winblad B, et al. Among authors: staufenbiel m. Lancet Neurol. 2012 Jul;11(7):597-604. doi: 10.1016/S1474-4422(12)70140-0. Epub 2012 Jun 6. Lancet Neurol. 2012. PMID: 22677258 Clinical Trial.
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease.
Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Häsler LM, Baumann F, Nyström S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarström P, Staufenbiel M, Walker LC, Jucker M. Rasmussen J, et al. Among authors: staufenbiel m. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13018-13023. doi: 10.1073/pnas.1713215114. Epub 2017 Nov 20. Proc Natl Acad Sci U S A. 2017. PMID: 29158413 Free PMC article.
Therapeutic approaches to Alzheimer's disease.
Klafki HW, Staufenbiel M, Kornhuber J, Wiltfang J. Klafki HW, et al. Among authors: staufenbiel m. Brain. 2006 Nov;129(Pt 11):2840-55. doi: 10.1093/brain/awl280. Epub 2006 Oct 3. Brain. 2006. PMID: 17018549 Review.
Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid.
Fritschi SK, Langer F, Kaeser SA, Maia LF, Portelius E, Pinotsi D, Kaminski CF, Winkler DT, Maetzler W, Keyvani K, Spitzer P, Wiltfang J, Kaminski Schierle GS, Zetterberg H, Staufenbiel M, Jucker M. Fritschi SK, et al. Among authors: staufenbiel m. Brain. 2014 Nov;137(Pt 11):2909-2915. doi: 10.1093/brain/awu255. Epub 2014 Sep 10. Brain. 2014. PMID: 25212850 Free PMC article.
The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.
Wiessner C, Wiederhold KH, Tissot AC, Frey P, Danner S, Jacobson LH, Jennings GT, Lüönd R, Ortmann R, Reichwald J, Zurini M, Mir A, Bachmann MF, Staufenbiel M. Wiessner C, et al. Among authors: staufenbiel m. J Neurosci. 2011 Jun 22;31(25):9323-31. doi: 10.1523/JNEUROSCI.0293-11.2011. J Neurosci. 2011. PMID: 21697382 Free PMC article.
The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
Neumann U, Ufer M, Jacobson LH, Rouzade-Dominguez ML, Huledal G, Kolly C, Lüönd RM, Machauer R, Veenstra SJ, Hurth K, Rueeger H, Tintelnot-Blomley M, Staufenbiel M, Shimshek DR, Perrot L, Frieauff W, Dubost V, Schiller H, Vogg B, Beltz K, Avrameas A, Kretz S, Pezous N, Rondeau JM, Beckmann N, Hartmann A, Vormfelde S, David OJ, Galli B, Ramos R, Graf A, Lopez Lopez C. Neumann U, et al. Among authors: staufenbiel m. EMBO Mol Med. 2018 Nov;10(11):e9316. doi: 10.15252/emmm.201809316. EMBO Mol Med. 2018. PMID: 30224383 Free PMC article. Clinical Trial.
Early Aβ reduction prevents progression of cerebral amyloid angiopathy.
Schelle J, Wegenast-Braun BM, Fritschi SK, Kaeser SA, Jährling N, Eicke D, Skodras A, Beschorner N, Obermueller U, Häsler LM, Wolfer DP, Mueggler T, Shimshek DR, Neumann U, Dodt HU, Staufenbiel M, Jucker M. Schelle J, et al. Among authors: staufenbiel m. Ann Neurol. 2019 Oct;86(4):561-571. doi: 10.1002/ana.25562. Epub 2019 Aug 19. Ann Neurol. 2019. PMID: 31359452
214 results