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Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.
De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M. De SK, et al. Among authors: stebbins jl. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. doi: 10.1016/j.bmc.2009.12.013. Epub 2009 Dec 11. Bioorg Med Chem. 2010. PMID: 20045647 Free PMC article.
Structure-based discovery of a new class of Bcl-xL antagonists.
Rega MF, Leone M, Jung D, Cotton NJ, Stebbins JL, Pellecchia M. Rega MF, et al. Among authors: stebbins jl. Bioorg Chem. 2007 Aug;35(4):344-53. doi: 10.1016/j.bioorg.2007.03.001. Epub 2007 May 21. Bioorg Chem. 2007. PMID: 17512966 Free PMC article.
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.
Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13. doi: 10.1073/pnas.0805677105. Epub 2008 Oct 15. Proc Natl Acad Sci U S A. 2008. PMID: 18922779 Free PMC article.
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.
De SK, Stebbins JL, Chen LH, Riel-Mehan M, Machleidt T, Dahl R, Yuan H, Emdadi A, Barile E, Chen V, Murphy R, Pellecchia M. De SK, et al. Among authors: stebbins jl. J Med Chem. 2009 Apr 9;52(7):1943-52. doi: 10.1021/jm801503n. J Med Chem. 2009. PMID: 19271755 Free PMC article.
37 results