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Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.
Awwad K, Steinbrink SD, Frömel T, Lill N, Isaak J, Häfner AK, Roos J, Hofmann B, Heide H, Geisslinger G, Steinhilber D, Freeman BA, Maier TJ, Fleming I. Awwad K, et al. Among authors: steinbrink sd. Antioxid Redox Signal. 2014 Jun 10;20(17):2667-80. doi: 10.1089/ars.2013.5473. Epub 2014 Feb 3. Antioxid Redox Signal. 2014. PMID: 24206143 Free PMC article.
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.
Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ. Steinbrink SD, et al. Cell Mol Life Sci. 2010 Mar;67(5):797-806. doi: 10.1007/s00018-009-0206-0. Epub 2009 Nov 29. Cell Mol Life Sci. 2010. PMID: 20091083
Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport.
Kahnt AS, Angioni C, Göbel T, Hofmann B, Roos J, Steinbrink SD, Rörsch F, Thomas D, Geisslinger G, Zacharowski K, Grösch S, Steinhilber D, Maier TJ. Kahnt AS, et al. Among authors: steinbrink sd. Front Pharmacol. 2022 Jan 21;12:782584. doi: 10.3389/fphar.2021.782584. eCollection 2021. Front Pharmacol. 2022. PMID: 35126121 Free PMC article.