Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1982 1
1984 1
1985 1
1990 3
1992 2
1996 1
1997 1
1998 2
1999 1
2000 2
2001 1
2002 2
2004 1
2005 2
2007 1
2008 2
2010 5
2011 1
2012 1
2013 4
2014 4
2015 8
2016 3
2017 7
2018 6
2019 1
2020 9
2021 5
2022 7
2023 5
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

91 results

Results by year

Filters applied: . Clear all
Page 1
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity.
Dane EL, Belessiotis-Richards A, Backlund C, Wang J, Hidaka K, Milling LE, Bhagchandani S, Melo MB, Wu S, Li N, Donahue N, Ni K, Ma L, Okaniwa M, Stevens MM, Alexander-Katz A, Irvine DJ. Dane EL, et al. Nat Mater. 2022 Jun;21(6):710-720. doi: 10.1038/s41563-022-01251-z. Epub 2022 May 23. Nat Mater. 2022. PMID: 35606429 Free PMC article.
We conjugated STING-activating cyclic dinucleotides (CDNs) to PEGylated lipids (CDN-PEG-lipids; PEG, polyethylene glycol) via a cleavable linker and incorporated them into lipid nanodiscs (LNDs), which are discoid nanoparticles formed by self-assembly. ...
We conjugated STING-activating cyclic dinucleotides (CDNs) to PEGylated lipids (CDN-PEG-lipids; PEG, polyethylene glycol) via a cleavable …
HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy.
Yu HA, Goto Y, Hayashi H, Felip E, Chih-Hsin Yang J, Reck M, Yoh K, Lee SH, Paz-Ares L, Besse B, Bironzo P, Kim DW, Johnson ML, Wu YL, John T, Kao S, Kozuki T, Massarelli E, Patel J, Smit E, Reckamp KL, Dong Q, Shrestha P, Fan PD, Patel P, Sporchia A, Sternberg DW, Sellami D, Jänne PA. Yu HA, et al. J Clin Oncol. 2023 Dec 10;41(35):5363-5375. doi: 10.1200/JCO.23.01476. Epub 2023 Sep 10. J Clin Oncol. 2023. PMID: 37689979 Free PMC article. Clinical Trial.
PURPOSE: Patritumab deruxtecan, or HER3-DXd, is an antibody-drug conjugate consisting of a fully human monoclonal antibody to human epidermal growth factor receptor 3 (HER3) attached to a topoisomerase I inhibitor payload via a stable tetrapeptide-based cleavable linker. W …
PURPOSE: Patritumab deruxtecan, or HER3-DXd, is an antibody-drug conjugate consisting of a fully human monoclonal antibody to human epiderma …
Architecture of the linker-scaffold in the nuclear pore.
Petrovic S, Samanta D, Perriches T, Bley CJ, Thierbach K, Brown B, Nie S, Mobbs GW, Stevens TA, Liu X, Tomaleri GP, Schaus L, Hoelz A. Petrovic S, et al. Science. 2022 Jun 10;376(6598):eabm9798. doi: 10.1126/science.abm9798. Epub 2022 Jun 10. Science. 2022. PMID: 35679425 Free PMC article.
RESULTS By biochemically mapping scaffold-binding regions of all fungal and human linker nucleoporins and determining crystal and single-particle cryo-EM structures of linker-scaffold complexes, we completed the characterization of the biochemically tractable lin …
RESULTS By biochemically mapping scaffold-binding regions of all fungal and human linker nucleoporins and determining crystal and sin …
Multifunctionality of the linker histones: an emerging role for protein-protein interactions.
McBryant SJ, Lu X, Hansen JC. McBryant SJ, et al. Cell Res. 2010 May;20(5):519-28. doi: 10.1038/cr.2010.35. Epub 2010 Mar 23. Cell Res. 2010. PMID: 20309017 Free PMC article. Review.
However, over the years many investigators have reported specific interactions between linker histones and proteins involved in important cellular processes. ...We then discuss the current state of knowledge of linker histone interactions with other proteins, and, w …
However, over the years many investigators have reported specific interactions between linker histones and proteins involved in impor …
Cleavable Linkers in Chemical Proteomics Applications.
Yang Y, Fonović M, Verhelst SH. Yang Y, et al. Methods Mol Biol. 2017;1491:185-203. doi: 10.1007/978-1-4939-6439-0_14. Methods Mol Biol. 2017. PMID: 27778290 Review.
Mass spectrometry is the primary method for target identification, and in the last decade, cleavable linkers have become a popular strategy to facilitate protein enrichment and identification. In this chapter, we provide an overview of cleavable linkers used in chem …
Mass spectrometry is the primary method for target identification, and in the last decade, cleavable linkers have become a popular st …
Cleavable linkers and their application in MS-based target identification.
Beard HA, Korovesis D, Chen S, Verhelst SHL. Beard HA, et al. Mol Omics. 2021 Apr 1;17(2):197-209. doi: 10.1039/d0mo00181c. Epub 2021 Jan 28. Mol Omics. 2021. PMID: 33507200 Review.
In addition, the linkers have enabled identification of modification sites. Overall, this has led to an increased knowledge of PTMs, enzyme function and drug action. This review gives an overview of the different types of cleavable linkers, and their benefits and li …
In addition, the linkers have enabled identification of modification sites. Overall, this has led to an increased knowledge of PTMs, …
Linker histone epitopes are hidden by in situ higher-order chromatin structure.
Teif VB, Gould TJ, Clarkson CT, Boyd L, Antwi EB, Ishaque N, Olins AL, Olins DE. Teif VB, et al. Epigenetics Chromatin. 2020 Jun 6;13(1):26. doi: 10.1186/s13072-020-00345-9. Epigenetics Chromatin. 2020. PMID: 32505195 Free PMC article.
Application of the xxChIP-seq versus H1 xChIP-seq method is particularly relevant to chromatin-associated proteins, such as linker histones, that play dynamic roles in establishing chromatin higher-order structure....
Application of the xxChIP-seq versus H1 xChIP-seq method is particularly relevant to chromatin-associated proteins, such as linker hi …
Rigidity and flexibility in the tetrasaccharide linker of proteoglycans from atomic-resolution molecular simulation.
Ng C, Nandha Premnath P, Guvench O. Ng C, et al. J Comput Chem. 2017 Jun 15;38(16):1438-1446. doi: 10.1002/jcc.24738. Epub 2017 Jan 19. J Comput Chem. 2017. PMID: 28101951
Certain classes of glycosaminoglycans such as chondroitin sulfate/dermatan sulfate and heparan sulfate utilize a specific tetrasaccharide linker for attachment to the protein component: GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser. Toward understanding the conformational …
Certain classes of glycosaminoglycans such as chondroitin sulfate/dermatan sulfate and heparan sulfate utilize a specific tetrasaccharide …
Biotin Protein Ligase Is a Target for New Antibacterials.
Feng J, Paparella AS, Booker GW, Polyak SW, Abell AD. Feng J, et al. Antibiotics (Basel). 2016 Jul 25;5(3):26. doi: 10.3390/antibiotics5030026. Antibiotics (Basel). 2016. PMID: 27463729 Free PMC article. Review.
Of particular promise are studies to replace the labile phosphoroanhydride linker present in biotinyl-5'-AMP with alternative bioisosteres. A novel in situ click approach using a mutant of S. aureus BPL as a template for the synthesis of triazole-based inhibitors is also p …
Of particular promise are studies to replace the labile phosphoroanhydride linker present in biotinyl-5'-AMP with alternative bioisos …
Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.
Meyer S, Stevens A, Paredes R, Schneider M, Walker MJ, Williamson AJK, Gonzalez-Sanchez MB, Smetsers S, Dalal V, Teng HY, White DJ, Taylor S, Muter J, Pierce A, de Leonibus C, Rockx DAP, Rooimans MA, Spooncer E, Stauffer S, Biswas K, Godthelp B, Dorsman J, Clayton PE, Sharan SK, Whetton AD. Meyer S, et al. Cell Death Dis. 2017 Jun 15;8(6):e2875. doi: 10.1038/cddis.2017.264. Cell Death Dis. 2017. PMID: 28617445 Free PMC article.
We modeled acquired cross-linker resistance with an FA-derived BRCA2-mutated acute myeloid leukemia (AML) platform. Associated with acquired cross-linker resistance was the expression of a functional BRCA2 protein variant lacking exon 5 and exon 7 (BRCA2(deltaE5+7)) …
We modeled acquired cross-linker resistance with an FA-derived BRCA2-mutated acute myeloid leukemia (AML) platform. Associated with a …
91 results