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Co-receptor requirements for fibroblast growth factor-19 signaling.
Wu X, Ge H, Gupte J, Weiszmann J, Shimamoto G, Stevens J, Hawkins N, Lemon B, Shen W, Xu J, Veniant MM, Li YS, Lindberg R, Chen JL, Tian H, Li Y. Wu X, et al. Among authors: stevens j. J Biol Chem. 2007 Oct 5;282(40):29069-72. doi: 10.1074/jbc.C700130200. Epub 2007 Aug 21. J Biol Chem. 2007. PMID: 17711860 Free article.
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors.
Wu X, Lemon B, Li X, Gupte J, Weiszmann J, Stevens J, Hawkins N, Shen W, Lindberg R, Chen JL, Tian H, Li Y. Wu X, et al. Among authors: stevens j. J Biol Chem. 2008 Nov 28;283(48):33304-9. doi: 10.1074/jbc.M803319200. Epub 2008 Oct 1. J Biol Chem. 2008. PMID: 18829467 Free PMC article.
FGF21 N- and C-termini play different roles in receptor interaction and activation.
Yie J, Hecht R, Patel J, Stevens J, Wang W, Hawkins N, Steavenson S, Smith S, Winters D, Fisher S, Cai L, Belouski E, Chen C, Michaels ML, Li YS, Lindberg R, Wang M, Véniant M, Xu J. Yie J, et al. Among authors: stevens j. FEBS Lett. 2009 Jan 5;583(1):19-24. doi: 10.1016/j.febslet.2008.11.023. Epub 2008 Dec 4. FEBS Lett. 2009. PMID: 19059246 Free article.
FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality.
Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG. Shalhoub V, et al. Among authors: stevens j. J Clin Invest. 2012 Jul;122(7):2543-53. doi: 10.1172/JCI61405. Epub 2012 Jun 25. J Clin Invest. 2012. PMID: 22728934 Free PMC article.
Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.
Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow M, Wang M, Luo Y, McKeehan W, Wang Z, Véniant MM, Li Y. Foltz IN, et al. Among authors: stevens j. Sci Transl Med. 2012 Nov 28;4(162):162ra153. doi: 10.1126/scitranslmed.3004690. Sci Transl Med. 2012. PMID: 23197570
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.
Smith R, Duguay A, Bakker A, Li P, Weiszmann J, Thomas MR, Alba BM, Wu X, Gupte J, Yang L, Stevens J, Hamburger A, Smith S, Chen J, Komorowski R, Moore KW, Véniant MM, Li Y. Smith R, et al. Among authors: stevens j. PLoS One. 2013 Apr 22;8(4):e61432. doi: 10.1371/journal.pone.0061432. Print 2013. PLoS One. 2013. PMID: 23630589 Free PMC article.
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies.
Grujic O, Stevens J, Chou RY, Weiszmann JV, Sekirov L, Thomson C, Badh A, Grauer S, Chan B, Graham K, Manchulenko K, Dillon TM, Li Y, Foltz IN. Grujic O, et al. Among authors: stevens j. Biochem Biophys Res Commun. 2017 May 13;486(4):985-991. doi: 10.1016/j.bbrc.2017.03.145. Epub 2017 Mar 28. Biochem Biophys Res Commun. 2017. PMID: 28363871
4,422 results