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Phenotypic features of genetically modified DMD-XKOXWT pigs.
Okamoto K, Matsunari H, Nakano K, Umeyama K, Hasegawa K, Uchikura A, Takayanagi S, Watanabe M, Ohgane J, Stirm M, Kurome M, Klymiuk N, Nagaya M, Wolf E, Nagashima H. Okamoto K, et al. Among authors: stirm m. Regen Ther. 2023 Sep 20;24:451-458. doi: 10.1016/j.reth.2023.09.010. eCollection 2023 Dec. Regen Ther. 2023. PMID: 37772130 Free PMC article.
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Stirm M, et al. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. Proc Natl Acad Sci U S A. 2023. PMID: 37428903 Free PMC article.
Pig models for Duchenne muscular dystrophy - from disease mechanisms to validation of new diagnostic and therapeutic concepts.
Stirm M, Fonteyne LM, Shashikadze B, Stöckl JB, Kurome M, Keßler B, Zakhartchenko V, Kemter E, Blum H, Arnold GJ, Matiasek K, Wanke R, Wurst W, Nagashima H, Knieling F, Walter MC, Kupatt C, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Stirm M, et al. Neuromuscul Disord. 2022 Jul;32(7):543-556. doi: 10.1016/j.nmd.2022.04.005. Epub 2022 Apr 25. Neuromuscul Disord. 2022. PMID: 35659494 Free article. Review.
A scalable, clinically severe pig model for Duchenne muscular dystrophy.
Stirm M, Fonteyne LM, Shashikadze B, Lindner M, Chirivi M, Lange A, Kaufhold C, Mayer C, Medugorac I, Kessler B, Kurome M, Zakhartchenko V, Hinrichs A, Kemter E, Krause S, Wanke R, Arnold GJ, Wess G, Nagashima H, Hrabĕ de Angelis M, Flenkenthaler F, Kobelke LA, Bearzi C, Rizzi R, Bähr A, Reese S, Matiasek K, Walter MC, Kupatt C, Ziegler S, Bartenstein P, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Stirm M, et al. Dis Model Mech. 2021 Dec 1;14(12):dmm049285. doi: 10.1242/dmm.049285. Epub 2021 Dec 16. Dis Model Mech. 2021. PMID: 34796900 Free PMC article.