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Table representation of search results timeline featuring number of search results per year.

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2009 3
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93 results

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Page 1
STK25: a viable therapeutic target for cancer treatments?
Chen KQ, Lei GL, Ke BY, Chen L, Wang ZB, Wang SZ. Chen KQ, et al. Anticancer Drugs. 2023 Oct 1;34(9):995-1001. doi: 10.1097/CAD.0000000000001490. Epub 2023 Dec 23. Anticancer Drugs. 2023. PMID: 36728989 Review.
More and more studies have revealed a strong correlation between STK25 and human diseases. On the one hand, STK25 can affect glucose and fatty acid metabolism in normal cells or tumors. ...This article reviews the composition and function of STK25, the energy …
More and more studies have revealed a strong correlation between STK25 and human diseases. On the one hand, STK25 can affect g …
STK25 enhances hepatocellular carcinoma progression through the STRN/AMPK/ACC1 pathway.
Zhang Y, Xu J, Qiu Z, Guan Y, Zhang X, Zhang X, Chai D, Chen C, Hu Q, Wang W. Zhang Y, et al. Cancer Cell Int. 2022 Jan 5;22(1):4. doi: 10.1186/s12935-021-02421-w. Cancer Cell Int. 2022. PMID: 34986838 Free PMC article.
Consistently, STK25 knockdown inhibited tumor growth in xenograft mouse model. ...Accordingly, high expression of STK25 may be associated with HCC patients and poor prognosis, which implicates STK25 could be a potential target for lipid metabolism in cancer t …
Consistently, STK25 knockdown inhibited tumor growth in xenograft mouse model. ...Accordingly, high expression of STK25 may be …
STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
Zhang X, Wang BZ, Kim M, Nash TR, Liu B, Rao J, Lock R, Tamargo M, Soni RK, Belov J, Li E, Vunjak-Novakovic G, Fine B. Zhang X, et al. Cell Rep. 2022 Aug 16;40(7):111203. doi: 10.1016/j.celrep.2022.111203. Cell Rep. 2022. PMID: 35977512 Free PMC article.
Here, we utilize human induced pluripotent stem cell cardiomyocytes (iPSC-CMs) to identify STK25 as a kinase of the type Ialpha regulatory subunit PRKAR1A. ...Together, these data support STK25 as a negative regulator of PKA signaling through phosphorylation of PRKA …
Here, we utilize human induced pluripotent stem cell cardiomyocytes (iPSC-CMs) to identify STK25 as a kinase of the type Ialpha regul …
STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
Matsuki T, Iio A, Ueda M, Tsuneura Y, Howell BW, Nakayama A. Matsuki T, et al. J Neurosci. 2021 Oct 27;41(43):8887-8903. doi: 10.1523/JNEUROSCI.0523-21.2021. Epub 2021 Sep 13. J Neurosci. 2021. PMID: 34518307 Free PMC article.
Precise control of neuronal migration is required for the laminar organization of the neocortex and critical for brain function. We previously reported that the acute disruption of the Stk25 gene (Stk25 conditional knock-out; cKO) during mouse embryogenesis causes a …
Precise control of neuronal migration is required for the laminar organization of the neocortex and critical for brain function. We previous …
STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.
Bae SJ, Ni L, Luo X. Bae SJ, et al. Elife. 2020 Apr 15;9:e54863. doi: 10.7554/eLife.54863. Elife. 2020. PMID: 32292165 Free PMC article.
Depletion of STK25 enhances MST2 activation without affecting the integrity of STRIPAK(SLMAP). STK25 directly phosphorylates SAV1 and diminishes the ability of SAV1 to inhibit STRIPAK. ...
Depletion of STK25 enhances MST2 activation without affecting the integrity of STRIPAK(SLMAP). STK25 directly phosphorylates S …
Activation of YAP1 by STK25 contributes to the progression of hepatocellular carcinoma.
Jiang J, Zheng Y, Chen F, Dong L, Guo X. Jiang J, et al. Tissue Cell. 2022 Jun;76:101797. doi: 10.1016/j.tice.2022.101797. Epub 2022 Apr 6. Tissue Cell. 2022. PMID: 35421669
A pathogenic role of serine/threonine protein kinase 25 (STK25) has been observed in several chronic liver diseases. However, whether STK25 participates in hepatocellular carcinoma (HCC) remains unexplored. The current work aimed to explore the role and mechanism of …
A pathogenic role of serine/threonine protein kinase 25 (STK25) has been observed in several chronic liver diseases. However, whether …
Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.
Chen J, Gao P, Peng L, Liu T, Wu F, Xu K, Chen L, Tan F, Xing P, Wang Z, Di J, Jiang B, Su X. Chen J, et al. Mol Carcinog. 2022 Jun;61(6):572-586. doi: 10.1002/mc.23403. Epub 2022 Mar 29. Mol Carcinog. 2022. PMID: 35349179
In this study, we found that STK25 expression was decreased in CRC tissues and CRC patients with high STK25 expression had a favorable prognosis. Functional assays suggested that STK25 inhibition promoted autophagy in CRC cells. Overexpression of STK25 …
In this study, we found that STK25 expression was decreased in CRC tissues and CRC patients with high STK25 expression had a f …
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.
Kurhe Y, Caputo M, Cansby E, Xia Y, Kumari S, Anand SK, Howell BW, Marschall HU, Mahlapuu M. Kurhe Y, et al. Cell Mol Gastroenterol Hepatol. 2022;13(2):405-423. doi: 10.1016/j.jcmgh.2021.09.018. Epub 2021 Oct 6. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34624527 Free PMC article.
RESULTS: In both mouse models of NASH-driven HCC, the livers from Stk25(-/-) mice showed a markedly lower tumor burden compared with wild-type controls. ...CONCLUSIONS: This study provides evidence that antagonizing STK25 signaling hinders the development of NASH-re …
RESULTS: In both mouse models of NASH-driven HCC, the livers from Stk25(-/-) mice showed a markedly lower tumor burden compared with …
STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.
Sütt S, Cansby E, Paul A, Amrutkar M, Nuñez-Durán E, Kulkarni NM, Ståhlman M, Borén J, Laurencikiene J, Howell BW, Enerbäck S, Mahlapuu M. Sütt S, et al. J Endocrinol. 2018 Sep;238(3):187-202. doi: 10.1530/JOE-18-0182. Epub 2018 May 24. J Endocrinol. 2018. PMID: 29794231
Furthermore, in rodent HIB-1B cell line, STK25 depletion resulted in enhanced mitochondrial activity and consequently, reduced lipid droplet size, demonstrating an autonomous action for STK25 within adipocytes. In summary, we provide the first evidence for a key fun …
Furthermore, in rodent HIB-1B cell line, STK25 depletion resulted in enhanced mitochondrial activity and consequently, reduced lipid …
93 results