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TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.
Yang Y, Zhu Y, Zhou S, Tang P, Xu R, Zhang Y, Wei D, Wen J, Thorne RF, Zhang XD, Guan JL, Liu L, Wu M, Chen S. Yang Y, et al. EMBO J. 2022 Jul 18;41(14):e109777. doi: 10.15252/embj.2021109777. Epub 2022 Jun 7. EMBO J. 2022. PMID: 35670107 Free PMC article.
However, during starvation-induced autophagy, TRIM27 catalyzes non-degradative K6- and K11-linked ubiquitination of the serine/threonine kinase 38-like (STK38L) kinase. In turn, STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, ren …
However, during starvation-induced autophagy, TRIM27 catalyzes non-degradative K6- and K11-linked ubiquitination of the serine/threonine kin …
STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.
Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. Grant TJ, et al. Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3. Oncotarget. 2017. PMID: 29108249 Free PMC article.
Therefore, we determined whether PDAC cell lines are dependent on STK38L expression for proliferation and viability. STK38L encodes a serine/threonine kinase, which shares homology with Hippo pathway kinases LATS1/2. ...LATS2 depletion partially rescues the cytostat …
Therefore, we determined whether PDAC cell lines are dependent on STK38L expression for proliferation and viability. STK38L en …
TRIMming down autophagy in breast cancer.
Thorne RF, Yang Y, Wu M, Chen S. Thorne RF, et al. Autophagy. 2022 Oct;18(10):2512-2513. doi: 10.1080/15548627.2022.2105557. Epub 2022 Jul 27. Autophagy. 2022. PMID: 35897149 Free PMC article.
TRIM27 ubiquitinates and activates STK38L which in turn phosphorylates ULK1, delivering ULK1 in a permissive state for hyper-ubiquitination by TRIM27. Thus, TRIM27 and STK38L kinase act in concert as a rheostat to control ULK1 levels. ...
TRIM27 ubiquitinates and activates STK38L which in turn phosphorylates ULK1, delivering ULK1 in a permissive state for hyper-ubiquiti …
LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
Wang S, Chu F, Xia R, Guan J, Zhou L, Fang X, Dai T, Xie F, Zhang L, Zhou F. Wang S, et al. Cell Rep. 2022 Nov 22;41(8):111661. doi: 10.1016/j.celrep.2022.111661. Cell Rep. 2022. PMID: 36417850 Free article.
When serum is supplied, serine/threonine-protein kinase 38-like (STK38L), induced by serum response factor (SRF), phosphorylates IRF3 at Ser303, which prevents IRF3 from proteasome-mediated degradation in the rest state (non-infected), and ensures that enough IRF3 is calle …
When serum is supplied, serine/threonine-protein kinase 38-like (STK38L), induced by serum response factor (SRF), phosphorylates IRF3 …
Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd).
Goldstein O, Kukekova AV, Aguirre GD, Acland GM. Goldstein O, et al. Genomics. 2010 Dec;96(6):362-8. doi: 10.1016/j.ygeno.2010.09.003. Epub 2010 Sep 29. Genomics. 2010. PMID: 20887780 Free PMC article.
Although known to have roles in neuronal cell function, the STK38L pathway has not previously been implicated in normal or abnormal photoreceptor development. Loss of STK38L function in erd provides novel potential insights into the role of the STK38L pathway …
Although known to have roles in neuronal cell function, the STK38L pathway has not previously been implicated in normal or abnormal p …
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
Chen H, Chen G, Li G, Zhang S, Chen H, Chen Y, Duggan D, Hu Z, Chen J, Zhao Y, Zhao Y, Huang H, Zheng SL, Trent JM, Yu L, Jiang D, Mo Z, Wang H, Mou Y, Jiang T, Mao Y, Xu J, Lu D. Chen H, et al. Int J Cancer. 2019 Nov 1;145(9):2372-2382. doi: 10.1002/ijc.32179. Epub 2019 Mar 18. Int J Cancer. 2019. PMID: 30714141 Free article.
In addition to confirming two associations reported in other ancestry groups, this study identified one new risk-associated locus for glioma on chromosome 12p11.23 (rs10842893, p(meta) = 2.33x10-12, STK38L) as well as a promising association at 15q15-21.1 (rs4774756, p(met …
In addition to confirming two associations reported in other ancestry groups, this study identified one new risk-associated locus for glioma …
[Role of PLAT, PKHD1L1, STK38L and TEAD1 genes Alu-polymorphism for longevity].
Erdman VV, Karimov DD, Nasibullin TR, Timasheva IR, Tuktarova IA, Mustafina OE. Erdman VV, et al. Adv Gerontol. 2016;29(5):709-716. Adv Gerontol. 2016. PMID: 28556638 Russian.
The distribution of allele and genotype frequencies of Alu(I/D)-polymorphic sites in PLAT (TPA25), PKHD1L1 (Yb8AC702), STK38L (Ya5ac2145) TEAD1 (Ya5ac2013) genes was first characterized in the ethnically homogeneous group (Tatars from the Republic of Bashkortostan, Russia) …
The distribution of allele and genotype frequencies of Alu(I/D)-polymorphic sites in PLAT (TPA25), PKHD1L1 (Yb8AC702), STK38L (Ya5ac2 …
Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina.
Berta ÁI, Boesze-Battaglia K, Genini S, Goldstein O, O'Brien PJ, Szél Á, Acland GM, Beltran WA, Aguirre GD. Berta ÁI, et al. PLoS One. 2011;6(9):e24074. doi: 10.1371/journal.pone.0024074. Epub 2011 Sep 30. PLoS One. 2011. PMID: 21980341 Free PMC article.
A homozygous mutation in STK38L in dogs impairs the late phase of photoreceptor development, and is followed by photoreceptor cell death (TUNEL) and proliferation (PCNA, PHH3) events that occur independently in different cells between 7-14 weeks of age. ...
A homozygous mutation in STK38L in dogs impairs the late phase of photoreceptor development, and is followed by photoreceptor cell de …
Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5.
Kleemann M, Schneider H, Unger K, Bereuther J, Fischer S, Sander P, Marion Schneider E, Fischer-Posovszky P, Riedel CU, Handrick R, Otte K. Kleemann M, et al. Cell Mol Life Sci. 2019 Feb;76(3):539-559. doi: 10.1007/s00018-018-2958-x. Epub 2018 Nov 3. Cell Mol Life Sci. 2019. PMID: 30392041
Elevated miR-493-3p levels downregulated the mRNA and protein expression levels of Serine/Threonine Kinase 38 Like (STK38L), High Mobility Group AT-Hook 2 (HMGA2) and AKT Serine/Threonine Kinase 2 (AKT2) by direct binding as demonstrated by luciferase reporter assays. Nota …
Elevated miR-493-3p levels downregulated the mRNA and protein expression levels of Serine/Threonine Kinase 38 Like (STK38L), High Mob …
Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways.
Duhart JC, Raftery LA. Duhart JC, et al. Front Cell Dev Biol. 2020 Mar 19;8:161. doi: 10.3389/fcell.2020.00161. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32266255 Free PMC article. Review.
Central to this emergent pathway are the NDR kinases, Tricornered, STK38, and STK38L. In Hippo signaling, NDR kinase activation is controlled by three activating interactions with a conserved set of proteins. ...These opposing Mob functions suggest that they coordinate the …
Central to this emergent pathway are the NDR kinases, Tricornered, STK38, and STK38L. In Hippo signaling, NDR kinase activation is co …
76 results