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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA. Holland WL, et al. Among authors: summers sa. J Clin Invest. 2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub 2011 Apr 1. J Clin Invest. 2011. PMID: 21490391 Free PMC article.
Sphingolipids and hepatic steatosis.
Bikman BT, Summers SA. Bikman BT, et al. Among authors: summers sa. Adv Exp Med Biol. 2011;721:87-97. doi: 10.1007/978-1-4614-0650-1_6. Adv Exp Med Biol. 2011. PMID: 21910084 Review.
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Sinha RA, et al. Among authors: summers sa. J Clin Invest. 2012 Jul;122(7):2428-38. doi: 10.1172/JCI60580. Epub 2012 Jun 11. J Clin Invest. 2012. PMID: 22684107 Free PMC article.
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