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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.
Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, Birnbaum MJ, Summers SA, Scherer PE. Holland WL, et al. Among authors: summers sa. Nat Med. 2011 Jan;17(1):55-63. doi: 10.1038/nm.2277. Epub 2010 Dec 26. Nat Med. 2011. PMID: 21186369 Free PMC article.
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA. Holland WL, et al. Among authors: summers sa. J Clin Invest. 2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub 2011 Apr 1. J Clin Invest. 2011. PMID: 21490391 Free PMC article.
Sphingolipids and hepatic steatosis.
Bikman BT, Summers SA. Bikman BT, et al. Among authors: summers sa. Adv Exp Med Biol. 2011;721:87-97. doi: 10.1007/978-1-4614-0650-1_6. Adv Exp Med Biol. 2011. PMID: 21910084 Review.
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Sinha RA, et al. Among authors: summers sa. J Clin Invest. 2012 Jul;122(7):2428-38. doi: 10.1172/JCI60580. Epub 2012 Jun 11. J Clin Invest. 2012. PMID: 22684107 Free PMC article.
Ceramides in insulin resistance and lipotoxicity.
Summers SA. Summers SA. Prog Lipid Res. 2006 Jan;45(1):42-72. doi: 10.1016/j.plipres.2005.11.002. Epub 2005 Dec 19. Prog Lipid Res. 2006. PMID: 16445986 Review.
172 results