Sun H - Search Results

1

Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions.

Eid E, Boross GN, Sun H, Msallam M, Singh SK, Brik A. Eid E, et al. Among authors: sun h. Bioconjug Chem. 2020 Mar 18;31(3):889-894. doi: 10.1021/acs.bioconjchem.0c00026. Epub 2020 Feb 24. Bioconjug Chem. 2020. PMID: 32069038 Free PMC article.

2

The Journey for the Total Chemical Synthesis of a 53 kDa Protein.

Sun H, Brik A. Sun H, et al. Acc Chem Res. 2019 Dec 17;52(12):3361-3371. doi: 10.1021/acs.accounts.9b00372. Epub 2019 Sep 19. Acc Chem Res. 2019. PMID: 31536331 Review.

3

Chemical chromatin ubiquitylation.

Jbara M, Sun H, Kamnesky G, Brik A. Jbara M, et al. Among authors: sun h. Curr Opin Chem Biol. 2018 Aug;45:18-26. doi: 10.1016/j.cbpa.2018.02.001. Epub 2018 Feb 20. Curr Opin Chem Biol. 2018. PMID: 29459258 Review.

4

Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases.

Sun H, Meledin R, Mali SM, Brik A. Sun H, et al. Chem Sci. 2018 Jan 11;9(6):1661-1665. doi: 10.1039/c7sc04518b. eCollection 2018 Feb 14. Chem Sci. 2018. PMID: 29675213 Free PMC article.

5

Palladium-Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-cysteine under Aqueous Conditions.

Laps S, Sun H, Kamnesky G, Brik A. Laps S, et al. Among authors: sun h. Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5729-5733. doi: 10.1002/anie.201900988. Epub 2019 Mar 20. Angew Chem Int Ed Engl. 2019. PMID: 30828918

6

De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains.

Nawatha M, Rogers JM, Bonn SM, Livneh I, Lemma B, Mali SM, Vamisetti GB, Sun H, Bercovich B, Huang Y, Ciechanover A, Fushman D, Suga H, Brik A. Nawatha M, et al. Among authors: sun h. Nat Chem. 2019 Jul;11(7):644-652. doi: 10.1038/s41557-019-0278-x. Epub 2019 Jun 10. Nat Chem. 2019. PMID: 31182821 Free PMC article.

7

Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-Linked Diubiquitin by a Twofold Strategy.

Huang Y, Nawatha M, Livneh I, Rogers JM, Sun H, Singh SK, Ciechanover A, Brik A, Suga H. Huang Y, et al. Among authors: sun h. Chemistry. 2020 Jun 26;26(36):8022-8027. doi: 10.1002/chem.202000273. Epub 2020 Jun 8. Chemistry. 2020. PMID: 32105365

8

Examining the role of phosphorylation of p19^INK4d in its stability and ubiquitination using chemical protein synthesis.

Msallam M, Sun H, Meledin R, Franz P, Brik A. Msallam M, et al. Among authors: sun h. Chem Sci. 2020 May 19;11(21):5526-5531. doi: 10.1039/c9sc06300e. eCollection 2020 Jun 7. Chem Sci. 2020. PMID: 32874495 Free PMC article.

9

Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles.

Sun H, Mali SM, Singh SK, Meledin R, Brik A, Kwon YT, Kravtsova-Ivantsiv Y, Bercovich B, Ciechanover A. Sun H, et al. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7805-7812. doi: 10.1073/pnas.1822148116. Epub 2019 Mar 13. Proc Natl Acad Sci U S A. 2019. PMID: 30867293 Free PMC article.

10

General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins.

Laps S, Atamleh F, Kamnesky G, Sun H, Brik A. Laps S, et al. Among authors: sun h. Nat Commun. 2021 Feb 8;12(1):870. doi: 10.1038/s41467-021-21209-0. Nat Commun. 2021. PMID: 33558523 Free PMC article.

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