Regioselective contribution of the cytochrome P-450 2D subfamily to propranolol metabolism in rat liver microsomes.
Masubuchi Y, Kagimoto N, Narimatsu S, Fujita S, Suzuki T.
Masubuchi Y, et al. Among authors: suzuki t.
Drug Metab Dispos. 1993 Nov-Dec;21(6):1012-6.
Drug Metab Dispos. 1993.
PMID: 7905378
The kinetic studies showed that the Vmax for propranolol 7-hydroxylase activity and the Vmax of high-affinity phases for propranolol 4- and 5-hydroxylase activities were markedly low in Dark Agouti rats compared with those in Wistar rats. The antibody against a cytochrome P-450 i …
The kinetic studies showed that the Vmax for propranolol 7-hydroxylase activity and the Vmax of high-affinity phases for propranolol 4- and …