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1998 1
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Page 1
Somatic Variants in SVIL in Cerebral Aneurysms.
Lai PMR, Ryu JY, Park SC, Gross BA, Dickinson LD, Dagen S, Aziz-Sultan MA, Boulos AS, Barrow DL, Batjer HH, Blackburn S, Chang EF, Chen PR, Colby GP, Cosgrove GR, David CA, Day AL, Frerichs KU, Niemela M, Ojemann SG, Patel NJ, Shi X, Valle-Giler EP, Wang AC, Welch BG, Zusman EE, Weiss ST, Du R. Lai PMR, et al. Neurol Genet. 2022 Nov 28;8(6):e200040. doi: 10.1212/NXG.0000000000200040. eCollection 2022 Dec. Neurol Genet. 2022. PMID: 36475054 Free PMC article.
RNA sequencing and the CRISPR/Cas9 system were then used to perform functional validation of our results. RESULTS: Somatic variants involved in supervillin (SVIL) or its regulation were found in 17% of aneurysm tissues. In the presence of a mutation in the SVIL gene …
RNA sequencing and the CRISPR/Cas9 system were then used to perform functional validation of our results. RESULTS: Somatic variants involved …
N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1.
Hu Z, Zhu L, Zhang Y, Chen B. Hu Z, et al. Bioengineered. 2022 Feb;13(2):3093-3107. doi: 10.1080/21655979.2022.2025697. Bioengineered. 2022. PMID: 35068325 Free PMC article.
Mechanistically, METTL3 increased the m6A modification and transcript stability of SVIL-AS1. The enhanced SVIL-AS1 expression mediated by METTL3 suppressed E2F1 and E2F1-target genes. Moreover, SVIL-AS1 accelerated E2F1 degradation. The reduction in cell prol …
Mechanistically, METTL3 increased the m6A modification and transcript stability of SVIL-AS1. The enhanced SVIL-AS1 expression …
Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration.
Nie Z, Guo N, Peng Y, Gao Y, Cao H, Zhang S. Nie Z, et al. Sci Rep. 2023 Sep 5;13(1):14595. doi: 10.1038/s41598-023-41759-1. Sci Rep. 2023. PMID: 37670039 Free PMC article.
SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. It has been reported to be closely related to the occurrence and development of various tumors. However, the mechanism of SVIL in bladder cancer has not been reported ye …
SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. It has been reported to be closely r …
Deep learning enables genetic analysis of the human thoracic aorta.
Pirruccello JP, Chaffin MD, Chou EL, Fleming SJ, Lin H, Nekoui M, Khurshid S, Friedman SF, Bick AG, Arduini A, Weng LC, Choi SH, Akkad AD, Batra P, Tucker NR, Hall AW, Roselli C, Benjamin EJ, Vellarikkal SK, Gupta RM, Stegmann CM, Juric D, Stone JR, Vasan RS, Ho JE, Hoffmann U, Lubitz SA, Philippakis AA, Lindsay ME, Ellinor PT. Pirruccello JP, et al. Nat Genet. 2022 Jan;54(1):40-51. doi: 10.1038/s41588-021-00962-4. Epub 2021 Nov 26. Nat Genet. 2022. PMID: 34837083 Free PMC article.
Transcriptome-wide analyses, rare-variant burden tests and human aortic single nucleus RNA sequencing prioritized genes including SVIL, which was strongly associated with descending aortic diameter. ...
Transcriptome-wide analyses, rare-variant burden tests and human aortic single nucleus RNA sequencing prioritized genes including SVIL …
Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.
Tadros R, Zheng SL, Grace C, Jordà P, Francis C, Jurgens SJ, Thomson KL, Harper AR, Ormondroyd E, West DM, Xu X, Theotokis PI, Buchan RJ, McGurk KA, Mazzarotto F, Boschi B, Pelo E, Lee M, Noseda M, Varnava A, Vermeer AM, Walsh R, Amin AS, van Slegtenhorst MA, Roslin N, Strug LJ, Salvi E, Lanzani C, de Marvao A; Hypergenes InterOmics Collaborators; Roberts JD, Tremblay-Gravel M, Giraldeau G, Cadrin-Tourigny J, L'Allier PL, Garceau P, Talajic M, Pinto YM, Rakowski H, Pantazis A, Baksi J, Halliday BP, Prasad SK, Barton PJ, O'Regan DP, Cook SA, de Boer RA, Christiaans I, Michels M, Kramer CM, Ho CY, Neubauer S; HCMR Investigators; Matthews PM, Wilde AA, Tardif JC, Olivotto I, Adler A, Goel A, Ware JS, Bezzina CR, Watkins H. Tadros R, et al. medRxiv [Preprint]. 2023 Feb 6:2023.01.28.23285147. doi: 10.1101/2023.01.28.23285147. medRxiv. 2023. PMID: 36778260 Free PMC article. Preprint.
Amongst the common variant HCM loci, we identify a novel HCM disease gene, SVIL, which encodes the actin-binding protein supervillin, showing that rare truncating SVIL variants cause HCM. ...
Amongst the common variant HCM loci, we identify a novel HCM disease gene, SVIL, which encodes the actin-binding protein supervillin, …
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
Kuang C, Xia M, An G, Liu C, Hu C, Zhang J, Liu Z, Meng B, Su P, Xia J, Guo J, Zhu Y, Liu X, Wu X, Shen Y, Feng X, He Y, Li J, Qiu L, Zhou J, Zhou W. Kuang C, et al. Nat Commun. 2023 Apr 13;14(1):2093. doi: 10.1038/s41467-023-37699-z. Nat Commun. 2023. PMID: 37055385 Free PMC article.
Extrinsic serine is transported into MKs through SLC38A1 and downregulates SVIL via SAM-mediated tri-methylation of H3K9, ultimately leading to the impairment of megakaryopoiesis. ...
Extrinsic serine is transported into MKs through SLC38A1 and downregulates SVIL via SAM-mediated tri-methylation of H3K9, ultimately …
Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages.
Zhou J, Que Y, Pan L, Li X, Zhu C, Jin L, Li S. Zhou J, et al. Inflammation. 2022 Feb;45(1):356-371. doi: 10.1007/s10753-021-01551-7. Epub 2021 Sep 3. Inflammation. 2022. PMID: 34480249
This work investigated the underlying molecular mechanisms of LPS regulating SVIL expression in macrophages and hence the possible role of SVIL in LPS-induced inflammation. We found that in THP-1-derived macrophages, LPS obviously increased SVIL mRNA and prot …
This work investigated the underlying molecular mechanisms of LPS regulating SVIL expression in macrophages and hence the possible ro …
Identification of a competing endogenous RNA axis "SVIL-AS1/miR-103a/ICE1" associated with chemoresistance in lung adenocarcinoma by comprehensive bioinformatics analysis.
Guo L, Ding L, Tang J. Guo L, et al. Cancer Med. 2021 Sep;10(17):6022-6034. doi: 10.1002/cam4.4132. Epub 2021 Jul 15. Cancer Med. 2021. PMID: 34264003 Free PMC article.
High expression of SVIl-AS1 and ICE1 corresponded to a favorable prognosis. High expression of miR-103a corresponded to a dismal prognosis. SVIl-AS1 was downregulated in DDP-resistant LUAD cells. SVIL-AS1 overexpression retarded the proliferation and DDP resi …
High expression of SVIl-AS1 and ICE1 corresponded to a favorable prognosis. High expression of miR-103a corresponded to a dismal prog …
The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing.
Hasegawa H, Hyodo T, Asano E, Ito S, Maeda M, Kuribayashi H, Natsume A, Wakabayashi T, Hamaguchi M, Senga T. Hasegawa H, et al. J Cell Sci. 2013 Aug 15;126(Pt 16):3627-37. doi: 10.1242/jcs.124818. Epub 2013 Jun 7. J Cell Sci. 2013. PMID: 23750008
In this report, we show that an actin/myosin-II-binding protein, supervillin (SVIL), is a substrate of PLK1. PLK1 phosphorylates Ser238 of SVIL, which can promote the localization of SVIL to the central spindle and association with PRC1. ...SVIL has bo …
In this report, we show that an actin/myosin-II-binding protein, supervillin (SVIL), is a substrate of PLK1. PLK1 phosphorylates Ser2 …
Supervillin promotes tumor angiogenesis in liver cancer.
Zhao C, Zhao Z, Wang Z, Hu L, Wang H, Fang Z. Zhao C, et al. Oncol Rep. 2020 Aug;44(2):674-684. doi: 10.3892/or.2020.7621. Epub 2020 May 25. Oncol Rep. 2020. PMID: 32468064 Free PMC article.
However, the functional relationships between SVIL and tumor angiogenesis in liver cancer have not yet been fully elucidated. ...SVIL may therefore be considered a potential tumor vascular biomarker and a promising therapeutic target for patients with liver cancer.. …
However, the functional relationships between SVIL and tumor angiogenesis in liver cancer have not yet been fully elucidated. ...S …
85 results