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Poly[3-(3,4-dihydroxyphenyl)glyceric acid], a new biologically active polymer from Symphytum asperum Lepech. and S. caucasicum Bieb. (Boraginaceae).
Barbakadze V, Kemertelidze E, Targamadze I, Mulkijanyan K, Shashkov AS, Usov AI. Barbakadze V, et al. Molecules. 2005 Sep 30;10(9):1135-44. doi: 10.3390/10091135. Molecules. 2005. PMID: 18007379 Free PMC article.
Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1 …
Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities w …
Phytochemical profiling and bioactivity assessment of underutilized Symphytum species in comparison with Symphytum officinale.
Luca SV, Zengin G, Kulinowski Ł, Sinan KI, Skalicka-Woźniak K, Trifan A. Luca SV, et al. J Sci Food Agric. 2024 May;104(7):3971-3981. doi: 10.1002/jsfa.13279. Epub 2024 Jan 22. J Sci Food Agric. 2024. PMID: 38252561
BACKGROUND: Symphytum (comfrey) genus, particularly Symphytum officinale, has been empirically used in folk medicine mainly for its potent anti-inflammatory properties. In an attempt to shed light on the valorization of less known taxa, the current study eval …
BACKGROUND: Symphytum (comfrey) genus, particularly Symphytum officinale, has been empirically used in folk medicine ma …
Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis.
Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Mulkijanyan K, Papadopoulos K, Agarwal C, Agarwal R. Shrotriya S, et al. Carcinogenesis. 2012 Aug;33(8):1572-80. doi: 10.1093/carcin/bgs202. Epub 2012 Jun 12. Carcinogenesis. 2012. PMID: 22693258 Free PMC article.
In the present study, we investigated the efficacy of a novel phytochemical poly[3-(3, 4-dihydroxyphenyl)glyceric acid] (p-DGA) from Caucasian species of comfrey (Symphytum caucasicum) and its synthetic derivative syn-2, 3-dihydroxy-3-(3, 4-dihydroxyphenyl) p …
In the present study, we investigated the efficacy of a novel phytochemical poly[3-(3, 4-dihydroxyphenyl)glyceric acid] (p-DGA) from Caucasi …
DEVELOPMENT OF FORMULATION AND TECHNOLOGY FOR THE POLY[3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID] GEL.
Gokadze S, Barbakadze V, Mulkijanyan K, Bakuridze L, Bakuridze A. Gokadze S, et al. Georgian Med News. 2017 Jan;(262):92-98. Georgian Med News. 2017. PMID: 28252436
Among the medicinal plants with the mentioned pharmacological actions, comfrey (Symphytum L.) should be distinguished. Phenolic polymer poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDGA) or poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], amounting approximately …
Among the medicinal plants with the mentioned pharmacological actions, comfrey (Symphytum L.) should be distinguished. Phenoli …
[Novel biologically active polymer of 3-(3,4-dihydroxyphenyl)glyceric acid from two types of the comphrey Symphytum asperum and S. caucasicvum (Boraginoceae)].
Barbakadze VV, Kemertelidze EP, Targamadze IL, Shashkov AS, Usov AI. Barbakadze VV, et al. Bioorg Khim. 2002 Jul-Aug;28(4):362-6. doi: 10.1023/a:1019552110312. Bioorg Khim. 2002. PMID: 12197395 Russian.
Two high-molecular water-soluble preparations with high anticomplement and antioxidant activity were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene] a …
Two high-molecular water-soluble preparations with high anticomplement and antioxidant activity were isolated from the roots of Symphytum …
Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family.
Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Petrou A, Geronikaki A, Ćirić A, Glamočlija J, Soković M. Barbakadze V, et al. Antibiotics (Basel). 2023 Feb 1;12(2):285. doi: 10.3390/antibiotics12020285. Antibiotics (Basel). 2023. PMID: 36830198 Free PMC article.
This study reports the antimicrobial activities of the biopolymers poly[3-(3,4-dihydoxyphenyl)glyceric acid] (PDHPGA) and poly[2-methoxycarbonyl-3-(3,4-dihydroxyphenyl)oxirane] (PMDHPO), extracted from the six plants of Boraginaceae family: Symphytum asperum (SA), S. ca …
This study reports the antimicrobial activities of the biopolymers poly[3-(3,4-dihydoxyphenyl)glyceric acid] (PDHPGA) and poly[2-methoxycarb …
Enzymatic Synthesis and Antimicrobial Activity of Oligomer Analogues of Medicinal Biopolymers from Comfrey and Other Species of the Boraginaceae Family.
Merlani M, Scheibel DM, Barbakadze V, Gogilashvili L, Amiranashvili L, Geronikaki A, Catania V, Schillaci D, Gallo G, Gitsov I. Merlani M, et al. Pharmaceutics. 2022 Jan 4;14(1):115. doi: 10.3390/pharmaceutics14010115. Pharmaceutics. 2022. PMID: 35057011 Free PMC article.
Antibacterial assessment of natural polyethers from different species of Boraginaceae family Symhytum asperum, S. caucasicum,S. grandiflorum, Anchusa italica, Cynoglossum officinale, and synthetic polymers, poly[2-methoxycarbonyl-3-(3,4-dimethoxyphenyl)oxirane (PMDMPO) and …
Antibacterial assessment of natural polyethers from different species of Boraginaceae family Symhytum asperum, S. caucasicum,S. grand …