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Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins.
Wang H, Hu L, Dalen K, Dorward H, Marcinkiewicz A, Russell D, Gong D, Londos C, Yamaguchi T, Holm C, Rizzo MA, Brasaemle D, Sztalryd C. Wang H, et al. Among authors: sztalryd c. J Biol Chem. 2009 Nov 13;284(46):32116-25. doi: 10.1074/jbc.M109.006726. Epub 2009 Aug 29. J Biol Chem. 2009. PMID: 19717842 Free PMC article.
Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes.
Su CL, Sztalryd C, Contreras JA, Holm C, Kimmel AR, Londos C. Su CL, et al. Among authors: sztalryd c. J Biol Chem. 2003 Oct 31;278(44):43615-9. doi: 10.1074/jbc.M301809200. Epub 2003 Jun 26. J Biol Chem. 2003. PMID: 12832420 Free article.
Both HSL and perilipin are substrates for polyphosphorylation by protein kinase A (PKA), and phosphorylation of perilipin is required to induce HSL to translocate from the cytosol to the surface of the lipid droplet, a critical step in the lipolytic reaction (Sztalryd C …
Both HSL and perilipin are substrates for polyphosphorylation by protein kinase A (PKA), and phosphorylation of perilipin is required to ind …
Oxidative tissue: perilipin 5 links storage with the furnace.
Wang H, Sztalryd C. Wang H, et al. Among authors: sztalryd c. Trends Endocrinol Metab. 2011 Jun;22(6):197-203. doi: 10.1016/j.tem.2011.03.008. Epub 2011 May 31. Trends Endocrinol Metab. 2011. PMID: 21632259 Free PMC article. Review.
74 results