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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1967 1
1974 2
1975 18
1976 13
1977 19
1978 22
1979 21
1980 28
1981 46
1982 49
1983 42
1984 70
1985 68
1986 55
1987 57
1988 56
1989 59
1990 64
1991 82
1992 88
1993 68
1994 63
1995 76
1996 72
1997 89
1998 80
1999 84
2000 103
2001 87
2002 92
2003 105
2004 111
2005 134
2006 146
2007 171
2008 170
2009 193
2010 221
2011 204
2012 211
2013 212
2014 202
2015 224
2016 185
2017 126
2018 210
2019 209
2020 245
2021 239
2022 199
2023 149
2024 38

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5,067 results

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Page 1
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers.
Lowery FJ, Krishna S, Yossef R, Parikh NB, Chatani PD, Zacharakis N, Parkhurst MR, Levin N, Sindiri S, Sachs A, Hitscherich KJ, Yu Z, Vale NR, Lu YC, Zheng Z, Jia L, Gartner JJ, Hill VK, Copeland AR, Nah SK, Masi RV, Gasmi B, Kivitz S, Paria BC, Florentin M, Kim SP, Hanada KI, Li YF, Ngo LT, Ray S, Shindorf ML, Levi ST, Shepherd R, Toy C, Parikh AY, Prickett TD, Kelly MC, Beyer R, Goff SL, Yang JC, Robbins PF, Rosenberg SA. Lowery FJ, et al. Among authors: shepherd r. Science. 2022 Feb 25;375(6583):877-884. doi: 10.1126/science.abl5447. Epub 2022 Feb 3. Science. 2022. PMID: 35113651 Free PMC article.
The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge for the engineering of cell-based cancer immunotherapies. ...
The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge for the engineering of cell-based cance …
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M; PEACE Consortium; Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S; TRACERx Renal Consortium. Au L, et al. Among authors: shepherd stc. Cancer Cell. 2021 Nov 8;39(11):1497-1518.e11. doi: 10.1016/j.ccell.2021.10.001. Epub 2021 Oct 28. Cancer Cell. 2021. PMID: 34715028 Free PMC article.
Maintenance of highly similar clusters of TCRs post-treatment predict response, suggesting ongoing antigen engagement and survival of families of T cells likely recognizing the same antigens. In responders, nivolumab-bound CD8(+) T cells are expanded and express GZM …
Maintenance of highly similar clusters of TCRs post-treatment predict response, suggesting ongoing antigen engagement and survival of famili …
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Gupta S, Simic M, Sagan SA, Shepherd C, Duecker J, Sobel RA, Dandekar R, Wu GF, Wu W, Pak JE, Hauser SL, Lim W, Wilson MR, Zamvil SS. Gupta S, et al. Among authors: shepherd c. Neurol Neuroimmunol Neuroinflamm. 2023 Jan 19;10(2):e200080. doi: 10.1212/NXI.0000000000200080. Print 2023 Mar. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 36657993 Free PMC article.
DISCUSSION: In contrast to previous data showing that anti-CD19 CAR-T cell treatment exacerbated EAE, we observed that anti-CD19 CAR-T cells ameliorated EAE. In addition, anti-CD19 CAR-T cells thoroughly depleted B cells in peripheral tissues and in the CNS. …
DISCUSSION: In contrast to previous data showing that anti-CD19 CAR-T cell treatment exacerbated EAE, we observed that anti-CD19 CAR- …
Low-Vision Services and the Glaucoma Patient.
Kaleem MA, Swenor BK, West SK, Im L, Shepherd JD. Kaleem MA, et al. Among authors: shepherd jd. Ophthalmol Glaucoma. 2019 May-Jun;2(3):127-129. doi: 10.1016/j.ogla.2019.01.012. Ophthalmol Glaucoma. 2019. PMID: 32672580 No abstract available.
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery.
Bery AI, Shepherd HM, Li W, Krupnick AS, Gelman AE, Kreisel D. Bery AI, et al. Among authors: shepherd hm. Cell Mol Life Sci. 2022 Jun 11;79(7):359. doi: 10.1007/s00018-022-04388-x. Cell Mol Life Sci. 2022. PMID: 35689679 Free PMC article. Review.
While their formation mimics embryologic lymphoid organogenesis, TLOs form after birth at ectopic sites in response to local inflammation resulting in their ability to mount diverse immune responses. The structure of TLOs can vary from clusters of B and T lymphocytes to hi …
While their formation mimics embryologic lymphoid organogenesis, TLOs form after birth at ectopic sites in response to local inflammation re …
Mechanistic diversity in MHC class I antigen recognition.
Barbosa CRR, Barton J, Shepherd AJ, Mishto M. Barbosa CRR, et al. Among authors: shepherd aj. Biochem J. 2021 Dec 22;478(24):4187-4202. doi: 10.1042/BCJ20200910. Biochem J. 2021. PMID: 34940832 Free PMC article. Review.
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mecha …
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that c …
T Cell Immunity to Bacterial Pathogens: Mechanisms of Immune Control and Bacterial Evasion.
Shepherd FR, McLaren JE. Shepherd FR, et al. Int J Mol Sci. 2020 Aug 26;21(17):6144. doi: 10.3390/ijms21176144. Int J Mol Sci. 2020. PMID: 32858901 Free PMC article. Review.
In the adaptive immune system, major histocompatibility complex (MHC)-restricted alphabeta T cells, along with unconventional alphabeta or gammadelta T cells, respond to bacterial antigens to orchestrate persisting protective immune responses and generate immunologi …
In the adaptive immune system, major histocompatibility complex (MHC)-restricted alphabeta T cells, along with unconventional alphabe …
Mice with diverse microbial exposure histories as a model for preclinical vaccine testing.
Fiege JK, Block KE, Pierson MJ, Nanda H, Shepherd FK, Mickelson CK, Stolley JM, Matchett WE, Wijeyesinghe S, Meyerholz DK, Vezys V, Shen SS, Hamilton SE, Masopust D, Langlois RA. Fiege JK, et al. Among authors: shepherd fk. Cell Host Microbe. 2021 Dec 8;29(12):1815-1827.e6. doi: 10.1016/j.chom.2021.10.001. Epub 2021 Nov 2. Cell Host Microbe. 2021. PMID: 34731647 Free PMC article.
Although SPF and co-housed mice were comparably susceptible to acute influenza infection, vaccine-induced humoral responses were dampened in co-housed mice, resulting in poor control upon challenge. Additionally, protective heterosubtypic T cell immunity was compromised in …
Although SPF and co-housed mice were comparably susceptible to acute influenza infection, vaccine-induced humoral responses were dampened in …
Inhibition of estrogen signaling in myeloid cells increases tumor immunity in melanoma.
Chakraborty B, Byemerwa J, Shepherd J, Haines CN, Baldi R, Gong W, Liu W, Mukherjee D, Artham S, Lim F, Bae Y, Brueckner O, Tavares K, Wardell SE, Hanks BA, Perou CM, Chang CY, McDonnell DP. Chakraborty B, et al. Among authors: shepherd j. J Clin Invest. 2021 Dec 1;131(23):e151347. doi: 10.1172/JCI151347. J Clin Invest. 2021. PMID: 34637400 Free PMC article.
This puts into context our observation that estrogens (E2) working through the estrogen receptor alpha (ERalpha) stimulated melanoma growth in murine models by skewing macrophage polarization toward an immune-suppressive state that promoted CD8+ T cell dysfunction and exha …
This puts into context our observation that estrogens (E2) working through the estrogen receptor alpha (ERalpha) stimulated melanoma growth …
T cell phenotypes in COVID-19 - a living review.
Hanna SJ, Codd AS, Gea-Mallorqui E, Scourfield DO, Richter FC, Ladell K, Borsa M, Compeer EB, Moon OR, Galloway SAE, Dimonte S, Capitani L, Shepherd FR, Wilson JD, Uhl LFK; Oxford-Cardiff COVID-19 Literature Consortium; Gallimore AM, Milicic A. Hanna SJ, et al. Among authors: shepherd fr. Oxf Open Immunol. 2020 Dec 29;2(1):iqaa007. doi: 10.1093/oxfimm/iqaa007. eCollection 2021. Oxf Open Immunol. 2020. PMID: 33575657 Free PMC article.
Therefore, T cell responses are also of considerable interest in vaccine development. ...We focus on SARS-CoV-2-specific T cells to elucidate markers that may indicate formation of antigen-specific T cell memory. ...
Therefore, T cell responses are also of considerable interest in vaccine development. ...We focus on SARS-CoV-2-specific T cel …
5,067 results