Global Characteristics and Dynamics of Single Immune Cells After Myocardial Infarction.
Zhuang L, Wang Y, Chen Z, Li Z, Wang Z, Jia K, Zhao J, Zhang H, Xie H, Lu L, Chen K, Chen L, Fukuda K, Sano M, Zhang R, Liu J, Yan X.
Zhuang L, et al.
J Am Heart Assoc. 2022 Dec 20;11(24):e027228. doi: 10.1161/JAHA.122.027228. Epub 2022 Dec 14.
J Am Heart Assoc. 2022.
PMID: 36515244
Free PMC article.
We showed the enriched Fos/AP-1 target gene loci in genome-wide association study signals for coronary artery diseases and MI. Targeting Fos/AP-1 with the selective inhibitor T5224 blunted leukocyte infiltration and alleviated cardiac dysfunction in the preclinical murine …
We showed the enriched Fos/AP-1 target gene loci in genome-wide association study signals for coronary artery diseases and MI. Targeting Fos …