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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 2
2000 6
2001 11
2002 10
2003 7
2004 6
2005 21
2006 15
2007 15
2008 12
2009 8
2010 6
2011 13
2012 9
2013 3
2014 5
2015 4
2016 5
2017 2
2020 4
2021 3
2022 2
2024 2

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154 results

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Page 1
Advances of CCR5 antagonists: From small molecules to macromolecules.
Qi B, Fang Q, Liu S, Hou W, Li J, Huang Y, Shi J. Qi B, et al. Eur J Med Chem. 2020 Dec 15;208:112819. doi: 10.1016/j.ejmech.2020.112819. Epub 2020 Sep 8. Eur J Med Chem. 2020. PMID: 32947226 Review.
This review focus on the recent research processes and pharmacological effects of CCR5 antagonists such as Maraviroc, TAK-779 and PRO 140. After focusing on the therapeutic effect of CCR5 antagonists on AIDS, it also discusses the therapeutic prospect of CCR5 in oth …
This review focus on the recent research processes and pharmacological effects of CCR5 antagonists such as Maraviroc, TAK-779 …
New anti-HIV agents and targets.
De Clercq E. De Clercq E. Med Res Rev. 2002 Nov;22(6):531-65. doi: 10.1002/med.10021. Med Res Rev. 2002. PMID: 12369088 Review.
In addition to the reverse transcriptase and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (i) viral adsorption, through binding to the viral envelope glycoprotein gp120 (polysulfates …
In addition to the reverse transcriptase and protease reaction, various other events in the HIV replicative cycle can be considered as poten …
New developments in anti-HIV chemotherapy.
De Clercq E. De Clercq E. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):258-75. doi: 10.1016/s0925-4439(02)00089-3. Biochim Biophys Acta. 2002. PMID: 12084468 Free article. Review.
In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as potential targets for chemotherapeutic intervention: (i) viral adsorption, through binding to the viral envelope glycoprotein gp120 (polysul …
In addition to the reverse transcriptase (RT) and protease reaction, various other events in the HIV replicative cycle can be considered as …
A study of the mechanisms responsible for the action of new immunosuppressants and their effects on rat small intestinal transplantation.
Miyagawa S, Kodama T, Matsuura R, Lo PC, Sakai R, Toyama C, Takama Y, Ihara Y, Kakuta Y, Yamanaka K, Matsunami K, Eguchi H, Maeda A, Okuyama H. Miyagawa S, et al. Transpl Immunol. 2022 Feb;70:101497. doi: 10.1016/j.trim.2021.101497. Epub 2021 Nov 14. Transpl Immunol. 2022. PMID: 34785307 Review.
An anti-MAdCAM antibody was next reported to significantly down-regulate CD4+ T cell infiltration in intestinal grafts by blocking the adhesion molecule, and could be useful as an induction therapy. Concerning TAK-779, this CCR5 and CXCR3 antagonist diminished the n …
An anti-MAdCAM antibody was next reported to significantly down-regulate CD4+ T cell infiltration in intestinal grafts by blocking the adhes …
New developments in anti-HIV chemotherapy.
De Clercq E. De Clercq E. Curr Med Chem. 2001 Nov;8(13):1543-72. doi: 10.2174/0929867013371842. Curr Med Chem. 2001. PMID: 11562282 Free article. Review.
In addition to the reverse transcriptase and protease step, various other events in the HIV replicative cycle are potential targets for chemotherapeutic intervention: (i) viral adsorption, through binding to the viral envelope glycoprotein gp120 (polysulfates, polysulfonates, pol …
In addition to the reverse transcriptase and protease step, various other events in the HIV replicative cycle are potential targets for chem …
Resistance to HIV-1 entry inhibitors.
Olson WC, Maddon PJ. Olson WC, et al. Curr Drug Targets Infect Disord. 2003 Dec;3(4):283-94. doi: 10.2174/1568005033481015. Curr Drug Targets Infect Disord. 2003. PMID: 14754430 Review.
TAK-779 (Takeda).
Esté JA. Esté JA. Curr Opin Investig Drugs. 2001 Mar;2(3):354-6. Curr Opin Investig Drugs. 2001. PMID: 11575704
TAK-779 is a CCR5 antagonist under investigation by Takeda and Kagoshima University for the potential treatment of HIV [324663], [342114]. TAK-779 inhibits chemokine binding to the CCR5 receptor at nanomolar concentrations. ...
TAK-779 is a CCR5 antagonist under investigation by Takeda and Kagoshima University for the potential treatment of HIV [324663 …
New advances in HIV entry inhibitors development.
Rusconi S, Scozzafava A, Mastrolorenzo A, Supuran CT. Rusconi S, et al. Curr Drug Targets Infect Disord. 2004 Dec;4(4):339-55. doi: 10.2174/1568005043340498. Curr Drug Targets Infect Disord. 2004. PMID: 15578975 Review.
Small molecule chemokine receptor antagonists acting as HIV entry inhibitors also were described in the last period, which interact both with the CXCR4 coreceptor (such as AMD3100; AMD3465; ALX40-4C; T22, T134 and T140), or which are antagonist of the CCR5 coreceptor (TAK- …
Small molecule chemokine receptor antagonists acting as HIV entry inhibitors also were described in the last period, which interact both wit …
Highlights in the development of new antiviral agents.
De Clercq E. De Clercq E. Mini Rev Med Chem. 2002 Apr;2(2):163-75. doi: 10.2174/1389557024605474. Mini Rev Med Chem. 2002. PMID: 12370077 Review.
This includes, for the treatment of HIV infections, virus adsorption inhibitors (cosalane derivatives, cyanovirin-N), co-receptor antagonists (TAK-779, AMD3100), viral fusion inhibitors (pentafuside T-20, betulinic acid derivatives), viral uncoating inhibitors (azod …
This includes, for the treatment of HIV infections, virus adsorption inhibitors (cosalane derivatives, cyanovirin-N), co-receptor antagonist …
The emerging role of fusion inhibitors in HIV infection.
De Clercq E. De Clercq E. Drugs R D. 1999 Nov;2(5):321-31. doi: 10.2165/00126839-199902050-00010. Drugs R D. 1999. PMID: 10728472 Review.
These include siamycin analogues, SPC 3 (a synthetic peptide derived from the V3 domain of gp120), pentafuside (T 20, DP 178) [a synthetic peptide corresponding to amino acid residues 127 to 162 of gp41], the betulinic acid derivative RPR 103611, TAK 779 (a low mole …
These include siamycin analogues, SPC 3 (a synthetic peptide derived from the V3 domain of gp120), pentafuside (T 20, DP 178) [a synthetic p …
154 results