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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2009 7
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2011 10
2012 15
2013 22
2014 33
2015 27
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548 results

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Page 1
Targeting TBK1 to overcome resistance to cancer immunotherapy.
Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu A, Ma X, Gwee J, Tiwari P, Du PP, Sindurakar P, Tian J, Mehta A, Schneider AM, Yizhak K, Sade-Feldman M, LaSalle T, Sharova T, Xie H, Liu S, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A, Spetz JKE, Qin X, Sarosiek KA, Zhang G, Kim JW, Su MY, Cicerchia AM, Rasmussen MQ, Klempner SJ, Juric D, Pai SI, Miller DM, Giobbie-Hurder A, Chen JH, Pelka K, Frederick DT, Stinson S, Ivanova E, Aref AR, Paweletz CP, Barbie DA, Sen DR, Fisher DE, Corcoran RB, Hacohen N, Sorger PK, Flaherty KT, Boland GM, Manguso RT, Jenkins RW. Sun Y, et al. Nature. 2023 Mar;615(7950):158-167. doi: 10.1038/s41586-023-05704-6. Epub 2023 Jan 12. Nature. 2023. PMID: 36634707 Free PMC article.
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking(1,2). ...Taken together, our results demonstrate that targeting TBK1 is an effective strategy to over …
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cance …
The role of TBK1 in cancer pathogenesis and anticancer immunity.
Runde AP, Mack R, S J PB, Zhang J. Runde AP, et al. J Exp Clin Cancer Res. 2022 Apr 9;41(1):135. doi: 10.1186/s13046-022-02352-y. J Exp Clin Cancer Res. 2022. PMID: 35395857 Free PMC article. Review.
Although TBK1 mutations have not been reported in human cancers, aberrant TBK1 activation has been implicated in the oncogenesis of several types of cancer, including leukemia and solid tumors with KRAS-activating mutations. ...In this review, we summa …
Although TBK1 mutations have not been reported in human cancers, aberrant TBK1 activation has been implicated in the on …
Targeting TANK-binding kinase 1 (TBK1) in cancer.
Revach OY, Liu S, Jenkins RW. Revach OY, et al. Expert Opin Ther Targets. 2020 Nov;24(11):1065-1078. doi: 10.1080/14728222.2020.1826929. Epub 2020 Oct 5. Expert Opin Ther Targets. 2020. PMID: 32962465 Free PMC article. Review.
Several lines of evidence support a role for TBK1 in cancer pathogenesis, but the specific roles and regulation of TBK1 remain incompletely understood. ...AREAS COVERED: This review provides an overview of the roles and regulation of TBK1 with a focus …
Several lines of evidence support a role for TBK1 in cancer pathogenesis, but the specific roles and regulation of TBK1 …
IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway.
Cai H, Yan L, Liu N, Xu M, Cai H. Cai H, et al. Biomed Pharmacother. 2020 Mar;123:109790. doi: 10.1016/j.biopha.2019.109790. Epub 2019 Dec 30. Biomed Pharmacother. 2020. PMID: 31896065 Free article.
Cervical cancer remains one of the leading causes of cancer death worldwide. Immunotherapy is the most promising cancer therapeutics in recent years and has gain positive results in several cancers in the clinic. ...
Cervical cancer remains one of the leading causes of cancer death worldwide. Immunotherapy is the most promising cancer …
TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss.
Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, Herring LE, Xie L, Chen X, Cabrera JC, Hong K, Liao C, Tan X, Baldwin AS, Gong K, Zhang Q. Hu L, et al. Cancer Discov. 2020 Mar;10(3):460-475. doi: 10.1158/2159-8290.CD-19-0837. Epub 2019 Dec 6. Cancer Discov. 2020. PMID: 31810986 Free PMC article.
Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. ...We identify that TBK1 phosphorylates p62/SQSTM1 on Ser366, which is essential for p62 stability and kidney cancer cell proliferation. ...
Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. ...We identify that …
Emerging roles of TBK1 in cancer immunobiology.
Miranda A, Shirley CA, Jenkins RW. Miranda A, et al. Trends Cancer. 2024 Mar 21:S2405-8033(24)00044-X. doi: 10.1016/j.trecan.2024.02.007. Online ahead of print. Trends Cancer. 2024. PMID: 38519366 Review.
While best known for its role in regulating innate immunity, TBK1 has emerged as a cancer cell-intrinsic immune evasion gene by virtue of its role in modulating cellular responses to inflammatory signals emanating from the immune system. Beyond its effect on canc …
While best known for its role in regulating innate immunity, TBK1 has emerged as a cancer cell-intrinsic immune evasion gene b …
Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy.
Jiang M, Jia K, Wang L, Li W, Chen B, Liu Y, Wang H, Zhao S, He Y, Zhou C. Jiang M, et al. Acta Pharm Sin B. 2021 Oct;11(10):2983-2994. doi: 10.1016/j.apsb.2021.01.003. Epub 2021 Jan 6. Acta Pharm Sin B. 2021. PMID: 34729299 Free PMC article. Review.
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-L1) and interact w …
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response ( …
TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway.
Jiang Q, Guan Y, Zheng J, Lu H. Jiang Q, et al. Immun Inflamm Dis. 2023 Mar;11(3):e796. doi: 10.1002/iid3.796. Immun Inflamm Dis. 2023. PMID: 36988258 Free PMC article.
We investigated the role of TANK-binding kinase 1 (TBK1) in the progression of thyroid cancer. METHODS: The expression of TBK1 in thyroid cancer and normal control tissues was analyzed using real-time quantitative polymerase chain reaction. ...The xeno …
We investigated the role of TANK-binding kinase 1 (TBK1) in the progression of thyroid cancer. METHODS: The expression of T …
Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway.
Ding C, Song Z, Shen A, Chen T, Zhang A. Ding C, et al. Acta Pharm Sin B. 2020 Dec;10(12):2272-2298. doi: 10.1016/j.apsb.2020.03.001. Epub 2020 Mar 13. Acta Pharm Sin B. 2020. PMID: 33354501 Free PMC article. Review.
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. ...Aberrant signaling of this pathway has bee …
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successf …
Roles for the IKK-Related Kinases TBK1 and IKKepsilon in Cancer.
Durand JK, Zhang Q, Baldwin AS. Durand JK, et al. Cells. 2018 Sep 15;7(9):139. doi: 10.3390/cells7090139. Cells. 2018. PMID: 30223576 Free PMC article. Review.
While primarily studied for their roles in innate immune response, the IkappaB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKepsilon also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases co …
While primarily studied for their roles in innate immune response, the IkappaB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1 …
548 results