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Year Number of Results
1994 1
1995 1
1996 2
1997 1
1998 3
1999 12
2000 11
2001 26
2002 29
2003 31
2004 31
2005 36
2006 39
2007 33
2008 50
2009 58
2010 56
2011 69
2012 68
2013 56
2014 67
2015 74
2016 72
2017 61
2018 77
2019 93
2020 82
2021 75
2022 66
2023 66
2024 24

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1,220 results

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Page 1
Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer.
Wang Y, Zheng L, Shang W, Yang Z, Li T, Liu F, Shao W, Lv L, Chai L, Qu L, Xu Q, Du J, Liang X, Zeng J, Jia J. Wang Y, et al. Cell Death Differ. 2022 Nov;29(11):2190-2202. doi: 10.1038/s41418-022-01008-w. Epub 2022 May 9. Cell Death Differ. 2022. PMID: 35534546 Free PMC article.
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance. ...Concordantly, TCF4 …
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation …
Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.
Zhou F, Gao H, Shang L, Li J, Zhang M, Wang S, Li R, Ye L, Yang S. Zhou F, et al. J Exp Clin Cancer Res. 2023 Jun 19;42(1):150. doi: 10.1186/s13046-023-02702-4. J Exp Clin Cancer Res. 2023. PMID: 37337284 Free PMC article.
CONCLUSIONS: Oridonin upregulated TP53, inhibited TCF4 transactivation, and induced ER stress dysregulation in tumor cells, promoting colorectal cancer cell death. ...And the inhibition of the TP53/TCF4 axis plays a key role in the anti-cancer effects …
CONCLUSIONS: Oridonin upregulated TP53, inhibited TCF4 transactivation, and induced ER stress dysregulation in tumor cells, promoting …
N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer.
Zou Y, Zheng S, Xie X, Ye F, Hu X, Tian Z, Yan SM, Yang L, Kong Y, Tang Y, Tian W, Xie J, Deng X, Zeng Y, Chen ZS, Tang H, Xie X. Zou Y, et al. Nat Commun. 2022 May 13;13(1):2672. doi: 10.1038/s41467-022-30217-7. Nat Commun. 2022. PMID: 35562334 Free PMC article.
FGFR4 inhibition enhances susceptibility to anti-HER2 therapy in resistant breast cancer. Mechanistically, m6A-hypomethylation regulated FGFR4 phosphorylates GSK-3beta and activates beta-catenin/TCF4 signaling to drive anti-HER2 resistance. ...Experiments involving …
FGFR4 inhibition enhances susceptibility to anti-HER2 therapy in resistant breast cancer. Mechanistically, m6A-hypomethylation regula …
TRIB3 Interacts With beta-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis.
Hua F, Shang S, Yang YW, Zhang HZ, Xu TL, Yu JJ, Zhou DD, Cui B, Li K, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Zhang C, Huang B, Hu ZW. Hua F, et al. Gastroenterology. 2019 Feb;156(3):708-721.e15. doi: 10.1053/j.gastro.2018.10.031. Epub 2018 Oct 24. Gastroenterology. 2019. PMID: 30365932
A peptide (P2-T3A6) that bound beta-catenin disrupted its interaction with TRIB3 and TCF4. In primary CRC cells and HCT-8 cells, P2-T3A6 decreased expression of genes regulated by beta-catenin and genes associated with cancer stem cells and decreased cell viability …
A peptide (P2-T3A6) that bound beta-catenin disrupted its interaction with TRIB3 and TCF4. In primary CRC cells and HCT-8 cells, P2-T …
A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.
Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, Nowosad A, Roda N, Makhzami S, Bervoets G, Maciel LF, Pulido-Vicuña CA, Pollaris L, Seurinck R, Zhao F, Flem-Karlsen K, Damsky W, Chen L, Karagianni D, Cinque S, Kint S, Vandereyken K, Rombaut B, Voet T, Vernaillen F, Annaert W, Lambrechts D, Boecxstaens V, Saeys Y, van den Oord J, Bosisio F, Karras P, Shain AH, Bosenberg M, Leucci E, Paschen A, Rambow F, Bechter O, Marine JC. Pozniak J, et al. Cell. 2024 Jan 4;187(1):166-183.e25. doi: 10.1016/j.cell.2023.11.037. Cell. 2024. PMID: 38181739 Free article.
Targeting TCF4 genetically or pharmacologically, using a bromodomain inhibitor, increased immunogenicity and sensitivity of MES cells to ICB and targeted therapy. We thereby uncovered a TCF4-dependent regulatory network that orchestrates multiple transcriptional pro …
Targeting TCF4 genetically or pharmacologically, using a bromodomain inhibitor, increased immunogenicity and sensitivity of MES cells …
Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.
Lee R, Li J, Li J, Wu CJ, Jiang S, Hsu WH, Chakravarti D, Chen P, LaBella KA, Li J, Spring DJ, Zhao D, Wang YA, DePinho RA. Lee R, et al. Cancer Discov. 2022 Jul 6;12(7):1702-1717. doi: 10.1158/2159-8290.CD-21-0680. Cancer Discov. 2022. PMID: 35537038 Free PMC article.
Inactivation of adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most sporadic colorectal cancers. ...Thus, APC deficiency activates a TCF4-TDO2-AhR-CXCL5 circuit that affects multiple cancer …
Inactivation of adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most …
Liquidambaric acid inhibits Wnt/beta-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2.
Yan R, Zhu H, Huang P, Yang M, Shen M, Pan Y, Zhang C, Zhou X, Li H, Ke X, Zhang W, Hao P, Qu Y. Yan R, et al. Cell Rep. 2022 Feb 1;38(5):110319. doi: 10.1016/j.celrep.2022.110319. Cell Rep. 2022. PMID: 35108540 Free article.
Mechanistically, TRAF2 positively regulates Wnt signaling by interacting with the N-terminal of beta-catenin via its TRAF-C domain; this interaction is disrupted in presence of LDA. Particularly, a TRAF2/beta-catenin/TCF4/TNIK complex is present in colon cancer cell …
Mechanistically, TRAF2 positively regulates Wnt signaling by interacting with the N-terminal of beta-catenin via its TRAF-C domain; this int …
TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression.
Sun S, Yang X, Qin X, Zhao Y. Sun S, et al. Protoplasma. 2020 May;257(3):921-930. doi: 10.1007/s00709-020-01480-6. Epub 2020 Jan 14. Protoplasma. 2020. PMID: 31933004
The present study aims to investigate the roles of TCF4 and its underlying mechanism in colorectal cancer (CRC). Doxorubicin-resistant DLD-1 (DLD1 DR), TCF4 overexpression, and TCF4 knockdown cell lines were constructed. ...The correlation between T …
The present study aims to investigate the roles of TCF4 and its underlying mechanism in colorectal cancer (CRC). Doxorubicin-r …
Streptonigrin Mitigates Lung Cancer-induced Cachexia by Suppressing TCF4/TWIST1-induced PTHLH Expression.
Fang XQ, Lee S, Kim YS, Han GE, Lim CH, Lim JH. Fang XQ, et al. Anticancer Res. 2023 Mar;43(3):1149-1157. doi: 10.21873/anticanres.16260. Anticancer Res. 2023. PMID: 36854496
The expression of PTHLH mRNA, which is transcriptionally regulated by the TCF4/TWIST1 complex in response to TGF-beta1 signalling, was decreased in streptonigrin-treated lung cancer cells. ...CONCLUSION: Streptonigrin exerts potent therapeutic effects on lung can …
The expression of PTHLH mRNA, which is transcriptionally regulated by the TCF4/TWIST1 complex in response to TGF-beta1 signalling, wa …
1,220 results