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21 results

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Page 1
Mouse oocytes develop in cysts with the help of nurse cells.
Niu W, Spradling AC. Niu W, et al. Cell. 2022 Jul 7;185(14):2576-2590.e12. doi: 10.1016/j.cell.2022.05.001. Epub 2022 May 26. Cell. 2022. PMID: 35623357 Free article.
The genes promoting oocyte development and nurse cell PCD are upregulated, whereas the genes that repress transfer, such as Tex14, and oocyte factors, such as Nobox and Lhx8, are under-expressed. ...
The genes promoting oocyte development and nurse cell PCD are upregulated, whereas the genes that repress transfer, such as Tex14, an …
Altered germline cyst formation and oogenesis in Tex14 mutant mice.
Ikami K, Nuzhat N, Abbott H, Pandoy R, Haky L, Spradling AC, Tanner H, Lei L. Ikami K, et al. Biol Open. 2021 Jun 15;10(6):bio058807. doi: 10.1242/bio.058807. Epub 2021 Jun 22. Biol Open. 2021. PMID: 34156079 Free PMC article.
To uncover the role of intercellular bridges in oocyte differentiation, we analyzed mutant female mice lacking testis-expressed 14 (TEX14), a protein involved in intercellular bridge formation and stabilization. In Tex14 homozygous mutant fetal ovaries, germ cells d …
To uncover the role of intercellular bridges in oocyte differentiation, we analyzed mutant female mice lacking testis-expressed 14 (TEX14 …
Inhibition mechanism of testis-expressed gene 14 (TEX14) in cytokinetic abscission: Well-tempered metadynamics simulation studies.
Cho Y, Nam Y, Lee HH, Chang R. Cho Y, et al. J Chem Phys. 2023 Jul 7;159(1):015102. doi: 10.1063/5.0153799. J Chem Phys. 2023. PMID: 37409705
Hence, a deeper understanding regarding the roles of TEX14 can provide significant insights into the inactivation of abscission and the inhibition of proliferation in cancer cells. ...Our results may help design synthetic TEX14 mimicking peptides, which can b …
Hence, a deeper understanding regarding the roles of TEX14 can provide significant insights into the inactivation of abscission and t …
Spermatogonial asynchrony in Tex14 mutant mice lacking intercellular bridges.
Rezende-Melo CA, Caldeira-Brant AL, Drumond-Bock AL, Buchold GM, Shetty G, Almeida FRCL, Matzuk MM, Hara K, Yoshida S, Meistrich ML, Chiarini-Garcia H. Rezende-Melo CA, et al. Reproduction. 2020 Aug;160(2):205-215. doi: 10.1530/REP-20-0118. Reproduction. 2020. PMID: 32438343
Evidence of the important role of such structures, known as intercellular bridges (ICB), in spermatogenesis has been implicated by the failure of spermatogenesis in testis-expressed gene 14 (Tex14) mutant mice, which lack the ICBs, to progress past the pachytene spermatocy …
Evidence of the important role of such structures, known as intercellular bridges (ICB), in spermatogenesis has been implicated by the failu …
Dazl determines primordial follicle formation through the translational regulation of Tex14.
Rosario R, Crichton JH, Stewart HL, Childs AJ, Adams IR, Anderson RA. Rosario R, et al. FASEB J. 2019 Dec;33(12):14221-14233. doi: 10.1096/fj.201901247R. Epub 2019 Oct 26. FASEB J. 2019. PMID: 31659914 Free PMC article.
Immunostaining of intercellular bridge component testis-expressed protein (Tex)14 showed 59% reduction in foci number and size, without any change in Tex14 mRNA levels. TEX14 expression was also confirmed in the human fetal ovary across gestation. ...Dazl determines …
Immunostaining of intercellular bridge component testis-expressed protein (Tex)14 showed 59% reduction in foci number and size, without any …
Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.
Kim HJ, Yoon J, Matsuura A, Na JH, Lee WK, Kim H, Choi JW, Park JE, Park SJ, Kim KT, Chang R, Lee BI, Yu YG, Shin YK, Jeong C, Rhee K, Lee HH. Kim HJ, et al. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12372-7. doi: 10.1073/pnas.1418606112. Epub 2015 Sep 21. Proc Natl Acad Sci U S A. 2015. PMID: 26392564 Free PMC article.
We also demonstrate that a high affinity and a low dissociation rate of TEX14 to CEP55, and an increase in the local concentration of TEX14, cooperatively prevent ALIX from recruiting ESCRT complexes to the midbody. The action mechanism of TEX14 suggests a sc …
We also demonstrate that a high affinity and a low dissociation rate of TEX14 to CEP55, and an increase in the local concentration of …
Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men.
Krausz C, Riera-Escamilla A, Moreno-Mendoza D, Holleman K, Cioppi F, Algaba F, Pybus M, Friedrich C, Wyrwoll MJ, Casamonti E, Pietroforte S, Nagirnaja L, Lopes AM, Kliesch S, Pilatz A, Carrell DT, Conrad DF, Ars E, Ruiz-Castañé E, Aston KI, Baarends WM, Tüttelmann F. Krausz C, et al. Genet Med. 2020 Dec;22(12):1956-1966. doi: 10.1038/s41436-020-0907-1. Epub 2020 Aug 3. Genet Med. 2020. PMID: 32741963 Free PMC article.
In addition, nine patients carried pathogenic variants in seven previously reported genes-TEX14, DMRT1, TEX11, SYCE1, MEIOB, MEI1, and STAG3-allowing to upgrade the clinical significance of these genes for diagnostic purposes. ...Wider implications include the understandin …
In addition, nine patients carried pathogenic variants in seven previously reported genes-TEX14, DMRT1, TEX11, SYCE1, MEIOB, MEI1, an …
High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients.
Chen J, Haanpää MK, Gruber JJ, Jäger N, Ford JM, Snyder MP. Chen J, et al. Clin Cancer Res. 2019 Sep 1;25(17):5301-5314. doi: 10.1158/1078-0432.CCR-18-2423. Epub 2019 Jun 7. Clin Cancer Res. 2019. PMID: 31175093 Free PMC article.
PURPOSE: Understanding and explaining hereditary predisposition to cancer has focused on the genetic etiology of the disease. However, mutations in known genes associated with breast cancer, such as BRCA1 and BRCA2, account for less than 25% of familial cases of bre …
PURPOSE: Understanding and explaining hereditary predisposition to cancer has focused on the genetic etiology of the disease. However …
Peripheral blood mononuclear cell derived biomarker detection using eXplainable Artificial Intelligence (XAI) provides better diagnosis of breast cancer.
Kumar S, Das A. Kumar S, et al. Comput Biol Chem. 2023 Jun;104:107867. doi: 10.1016/j.compbiolchem.2023.107867. Epub 2023 Apr 3. Comput Biol Chem. 2023. PMID: 37030103
The incidence and mortality rate of breast cancer increases yearly by an average of 1.44 % and 0.23 %, respectively. ...These genes may serve as early, non-invasive diagnostic and prognostic biomarkers for breast cancer patients....
The incidence and mortality rate of breast cancer increases yearly by an average of 1.44 % and 0.23 %, respectively. ...These genes m …
Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.
Kelemen LE, Wang X, Fredericksen ZS, Pankratz VS, Pharoah PD, Ahmed S, Dunning AM, Easton DF, Vierkant RA, Cerhan JR, Goode EL, Olson JE, Couch FJ. Kelemen LE, et al. Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1864-8. doi: 10.1158/1055-9965.EPI-08-0486. Epub 2009 May 19. Cancer Epidemiol Biomarkers Prev. 2009. PMID: 19454617 Free PMC article.
METHODS: We investigated 60 polymorphisms in the TUBD1, SEPT4, PRKCA, TBX2, TBX4, TEX14, TLK2, YPEL2, and PPM1E genes from this amplicon for association with breast cancer risk among 798 Caucasian breast cancer cases and 843 unaffected Caucasian controls from …
METHODS: We investigated 60 polymorphisms in the TUBD1, SEPT4, PRKCA, TBX2, TBX4, TEX14, TLK2, YPEL2, and PPM1E genes from this ampli …
21 results