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Year Number of Results
1994 1
1995 6
1996 10
1997 17
1998 12
1999 24
2000 11
2001 23
2002 19
2003 22
2004 22
2005 24
2006 27
2007 40
2008 32
2009 43
2010 50
2011 52
2012 49
2013 39
2014 52
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2017 62
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1,073 results

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Page 1
TGFBR1 and cancer susceptibility.
Pasche B, Pennison MJ, Jimenez H, Wang M. Pasche B, et al. Trans Am Clin Climatol Assoc. 2014;125:300-12. Trans Am Clin Climatol Assoc. 2014. PMID: 25125747 Free PMC article. Review.
The discovery of an association between TGFBR1*6A and cancer susceptibility led to the hypothesis that hypomorphic variants of the TGF-beta signaling pathway may predispose to the development of cancer. ...A case control study identified two haplotypes associ …
The discovery of an association between TGFBR1*6A and cancer susceptibility led to the hypothesis that hypomorphic variants of …
M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway.
Yin H, Chen L, Piao S, Wang Y, Li Z, Lin Y, Tang X, Zhang H, Zhang H, Wang X. Yin H, et al. Cell Death Differ. 2023 Mar;30(3):605-617. doi: 10.1038/s41418-021-00888-8. Epub 2021 Oct 9. Cell Death Differ. 2023. PMID: 34628486 Free PMC article.
Non-small cell lung cancer (NSCLC) has the highest mortality rate among all malignancies worldwide. ...The TGFBR1/SMAD2/SMAD3 pathway was also regulated by RMRP. In addition, RMRP promoted the cancer stem cells properties and epithelial mesenchymal transition …
Non-small cell lung cancer (NSCLC) has the highest mortality rate among all malignancies worldwide. ...The TGFBR1/SMAD2/SMAD3 …
TGFBR1 signaling and breast cancer.
Moore-Smith L, Pasche B. Moore-Smith L, et al. J Mammary Gland Biol Neoplasia. 2011 Jun;16(2):89-95. doi: 10.1007/s10911-011-9216-2. Epub 2011 Apr 5. J Mammary Gland Biol Neoplasia. 2011. PMID: 21461994 Free PMC article. Review.
TGFBR1*6A (*6A) is a common hypomorphic variant of the type I TGF-beta receptor gene (TGFBR1) that has been associated with risk for several forms of cancer, in particular breast cancer. ...A better understanding of the molecular mechanism of TGFBR1 …
TGFBR1*6A (*6A) is a common hypomorphic variant of the type I TGF-beta receptor gene (TGFBR1) that has been associated with ri …
Association between TGFBR1 polymorphisms and cancer risk: a meta-analysis of 35 case-control studies.
Wang YQ, Qi XW, Wang F, Jiang J, Guo QN. Wang YQ, et al. PLoS One. 2012;7(8):e42899. doi: 10.1371/journal.pone.0042899. Epub 2012 Aug 8. PLoS One. 2012. PMID: 22905183 Free PMC article. Review.
To derive a more precise estimation of the relation, we conducted a comprehensive meta-analysis of all available case-control studies relating the TGFBR1*6A and IVS7+24G>A polymorphisms of the TGFBR1 gene to the risk of cancer. ...CONCLUSIONS: Our investig …
To derive a more precise estimation of the relation, we conducted a comprehensive meta-analysis of all available case-control studies relati …
KIAA1199 drives immune suppression to promote colorectal cancer liver metastasis by modulating neutrophil infiltration.
Wang H, Zhang B, Li R, Chen J, Xu G, Zhu Y, Li J, Liang Q, Hua Q, Wang L, Wen L, Jin M, Fan J, Zhang D, Zhao L, Yu D, Lin Z, Ren J, Zhang T. Wang H, et al. Hepatology. 2022 Oct;76(4):967-981. doi: 10.1002/hep.32383. Epub 2022 Mar 2. Hepatology. 2022. PMID: 35108400
BACKGROUND AND AIMS: Metastasis is the primary cause of cancer mortality, and colorectal cancer (CRC) frequently metastasizes to the liver. ...Mechanistically, KIAA1199 activated the TGFbeta signaling pathway by interacting with the TGFBR1/2 to stimulate CXCL …
BACKGROUND AND AIMS: Metastasis is the primary cause of cancer mortality, and colorectal cancer (CRC) frequently metastasizes …
LncRNA LITATS1 suppresses TGF-beta-induced EMT and cancer cell plasticity by potentiating TbetaRI degradation.
Fan C, Wang Q, Kuipers TB, Cats D, Iyengar PV, Hagenaars SC, Mesker WE, Devilee P, Tollenaar RAEM, Mei H, Ten Dijke P. Fan C, et al. EMBO J. 2023 May 15;42(10):e112806. doi: 10.15252/embj.2022112806. Epub 2023 Mar 30. EMBO J. 2023. PMID: 36994542 Free PMC article.
Epithelial cells acquire mesenchymal phenotypes through epithelial-mesenchymal transition (EMT) during cancer progression. However, how epithelial cells retain their epithelial traits and prevent malignant transformation is not well understood. ...LITATS1 expression is red …
Epithelial cells acquire mesenchymal phenotypes through epithelial-mesenchymal transition (EMT) during cancer progression. However, h …
Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation.
Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massagué J, Sancho E, Batlle E. Calon A, et al. Cancer Cell. 2012 Nov 13;22(5):571-84. doi: 10.1016/j.ccr.2012.08.013. Cancer Cell. 2012. PMID: 23153532 Free PMC article.
A large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-beta pathway, yet, paradoxically, they are characterized by elevated TGF-beta production. ...The activity of TGF-beta on stromal cells increases the efficiency of organ colonization …
A large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-beta pathway, yet, paradoxically, they are …
Is TGFBR1*6A really associated with increased risk of cancer?
Zhang HT, Zhao J, Zheng SY, Chen XF. Zhang HT, et al. J Clin Oncol. 2005 Oct 20;23(30):7743-4; author reply 7744-6. doi: 10.1200/JCO.2005.02.9108. J Clin Oncol. 2005. PMID: 16234535 Review. No abstract available.
WFDC3 inhibits tumor metastasis by promoting the ERbeta-mediated transcriptional repression of TGFBR1 in colorectal cancer.
Liu T, Zhao M, Peng L, Chen J, Xing P, Gao P, Chen L, Qiao X, Wang Z, Di J, Qu H, Jiang B, Su X. Liu T, et al. Cell Death Dis. 2023 Jul 13;14(7):425. doi: 10.1038/s41419-023-05956-0. Cell Death Dis. 2023. PMID: 37443102 Free PMC article.
Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor beta (ERbeta). ...WFDC3 represses TGFBR1 expression through ERbeta-mediated transcription. Blocking TGFbeta signaling with galunisertib, a drug used in clin …
Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor beta (ERbeta). ...WFDC3 …
Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.
Lu ZZ, Sun C, Zhang X, Peng Y, Wang Y, Zeng Y, Zhu N, Yuan Y, Zeng MS. Lu ZZ, et al. Sci Adv. 2023 May 24;9(21):eadg1778. doi: 10.1126/sciadv.adg1778. Epub 2023 May 24. Sci Adv. 2023. PMID: 37224259 Free PMC article.
Furthermore, NRP1 interacts with TGF-beta receptor type 2 (TGFBR2) through their respective cytoplasmic domains and thus activates the TGFBR1/2 complex, which facilitates the macropinocytosis-mediated KSHV internalization via the small GTPases Cdc42 and Rac1. ...
Furthermore, NRP1 interacts with TGF-beta receptor type 2 (TGFBR2) through their respective cytoplasmic domains and thus activates the TG …
1,073 results