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mRNA export protein THOC5 as a tool for identification of target genes for cancer therapy.
Tran DD, Saran S, Koch A, Tamura T. Tran DD, et al. Cancer Lett. 2016 Apr 10;373(2):222-6. doi: 10.1016/j.canlet.2016.01.045. Epub 2016 Jan 28. Cancer Lett. 2016. PMID: 26828015 Review.
Recent exosome sequence data revealed that over 100 driver gene mutations with a number of signaling pathways are involved in human cancer formation, indicating that multiple signaling pathways will need to be inhibited for cancer therapy. In this review we firstly …
Recent exosome sequence data revealed that over 100 driver gene mutations with a number of signaling pathways are involved in human cance …
THOC2 and THOC5 Regulate Stemness and Radioresistance in Triple-Negative Breast Cancer.
Bai X, Ni J, Beretov J, Wang S, Dong X, Graham P, Li Y. Bai X, et al. Adv Sci (Weinh). 2021 Dec;8(24):e2102658. doi: 10.1002/advs.202102658. Epub 2021 Oct 27. Adv Sci (Weinh). 2021. PMID: 34708581 Free PMC article.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Radioresistance and stemness are substantial obstacles to TNBC treatment. ...Moreover, THOC2 or THOC5 depletion blocks the xenograft tumorigenesis and growth of radioresista …
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Radioresistance and stemness are substan …
Acylcarnitines promote gallbladder cancer metastasis through lncBCL2L11-THOC5-JNK axis.
Yang Y, Li H, Liu K, Zou L, Xiang S, Geng Y, Li X, Qiu S, Yang J, Cui X, Li L, Li Y, Li W, Yan S, Liu L, Wu X, Liu F, Wu W, Chen S, Liu Y. Yang Y, et al. J Transl Med. 2024 Mar 22;22(1):299. doi: 10.1186/s12967-024-05091-0. J Transl Med. 2024. PMID: 38519939 Free PMC article.
BACKGROUND: The progression of gallbladder cancer (GBC) is accompanied by abnormal fatty acid beta-oxidation (FAO) metabolism. ...LncBCL2L11 was identified in the joint analysis of highly metastatic cells and RNA sequencing data. LncBCl2L11 prevented the binding of THOC6 a …
BACKGROUND: The progression of gallbladder cancer (GBC) is accompanied by abnormal fatty acid beta-oxidation (FAO) metabolism. ...Lnc …
THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate.
Polenkowski M, Allister AB, Burbano de Lara S, Pierce A, Geary B, El Bounkari O, Wiehlmann L, Hoffmann A, Whetton AD, Tamura T, Tran DDH. Polenkowski M, et al. iScience. 2022 Dec 9;26(1):105784. doi: 10.1016/j.isci.2022.105784. eCollection 2023 Jan 20. iScience. 2022. PMID: 36590164 Free PMC article.
THOC5 is recruited close to high-density polymerase II sites, suggesting that THOC5 is involved in transcriptional elongation. ...These data demonstrate a novel function of THOC5 in transcription elongation....
THOC5 is recruited close to high-density polymerase II sites, suggesting that THOC5 is involved in transcriptional elongation. …
THOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation.
Tran DD, Koch A, Tamura T. Tran DD, et al. Cell Commun Signal. 2014 Jan 10;12:3. doi: 10.1186/1478-811X-12-3. Cell Commun Signal. 2014. PMID: 24410813 Free PMC article. Review.
THOC5 is evolutionarily conserved in higher eukaryotes, however the exact roles of THOC5 in transcription and mRNA export are still unclear. ...These include stimulation with growth factors/cytokines/chemokines, or DNA damage reagents. Furthermore, THOC5 is a …
THOC5 is evolutionarily conserved in higher eukaryotes, however the exact roles of THOC5 in transcription and mRNA export are …
THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.
Saran S, Tran DD, Klebba-Färber S, Moran-Losada P, Wiehlmann L, Koch A, Chopra H, Pabst O, Hoffmann A, Klopfleisch R, Tamura T. Saran S, et al. BMC Cell Biol. 2013 Nov 22;14:51. doi: 10.1186/1471-2121-14-51. BMC Cell Biol. 2013. PMID: 24267292 Free PMC article.
RESULTS: To examine whether THOC5 plays a role in general differentiation processes, we generated tamoxifen inducible THOC5 knockout mice. ...These data imply that THOC5 may be a useful tool for studying intestinal stem cells, for modifying the differentiatio …
RESULTS: To examine whether THOC5 plays a role in general differentiation processes, we generated tamoxifen inducible THOC5 kn …
THO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision.
Yuan X, Zhang T, Yao F, Liao Y, Liu F, Ren Z, Han L, Diao L, Li Y, Zhou B, He F, Wang L. Yuan X, et al. Circ Res. 2018 Aug 17;123(5):538-549. doi: 10.1161/CIRCRESAHA.118.313527. Circ Res. 2018. PMID: 30026254
Mechanistically, THOC2 and THOC5 physically interacted with and functionally relied on each other to bind to specific motifs on VSMC marker gene mRNAs. ...Last, THOC5 overexpression in injured rat carotid arteries significantly repressed loss of VSMC marker gene exp …
Mechanistically, THOC2 and THOC5 physically interacted with and functionally relied on each other to bind to specific motifs on VSMC …
Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death.
Saran S, Tran DD, Ewald F, Koch A, Hoffmann A, Koch M, Nashan B, Tamura T. Saran S, et al. Oncogene. 2016 Jul 21;35(29):3872-9. doi: 10.1038/onc.2015.433. Epub 2015 Nov 9. Oncogene. 2016. PMID: 26549021
Hepatocellular carcinoma (HCC) is a frequent form of cancer with a poor prognosis and with limited possibilities of medical intervention. ...These data imply that the suppression of the multiple THOC5 target genes may represent a novel strategy for HCC therapy....
Hepatocellular carcinoma (HCC) is a frequent form of cancer with a poor prognosis and with limited possibilities of medical intervent …
A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.
Griaud F, Pierce A, Gonzalez Sanchez MB, Scott M, Abraham SA, Holyoake TL, Tran DD, Tamura T, Whetton AD. Griaud F, et al. Leukemia. 2013 Apr;27(4):932-40. doi: 10.1038/leu.2012.283. Epub 2012 Oct 3. Leukemia. 2013. PMID: 23032722
THOC5 is a member of the THO complex that is involved in processing and transport of mRNA. We have shown previously that hematopoietic stem cells have an absolute requirement for THOC5 for survival and that THOC5 is phosphorylated on tyrosine 225 as a consequ …
THOC5 is a member of the THO complex that is involved in processing and transport of mRNA. We have shown previously that hematopoieti …
Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo.
Koch A, Saran S, Tran DD, Klebba-Färber S, Thiesler H, Sewald K, Schindler S, Braun A, Klopfleisch R, Tamura T. Koch A, et al. Cell Commun Signal. 2014 Nov 7;12:73. doi: 10.1186/s12964-014-0073-7. Cell Commun Signal. 2014. PMID: 25376987 Free PMC article.
Communication between cancer cells and organ-resident cells via cytokines/chemokines and direct cell-cell contacts are key steps for survival, proliferation and invasion of metastasized cancer cells in organs. Precision-cut liver slices (PCLS) are considered to clos …
Communication between cancer cells and organ-resident cells via cytokines/chemokines and direct cell-cell contacts are key steps for …
15 results