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Page 1
Mechanisms of Primary Membranous Nephropathy.
Gu Y, Xu H, Tang D. Gu Y, et al. Biomolecules. 2021 Mar 30;11(4):513. doi: 10.3390/biom11040513. Biomolecules. 2021. PMID: 33808418 Free PMC article. Review.
The clinical management of MN has steadily advanced owing to the identification of autoantibodies to the phospholipase A2 receptor (PLA2R) in 2009 and thrombospondin domain-containing 7A (THSD7A) in 2014 on the podocyte surface. Approximately 50-80% and 3-5% of primary MN …
The clinical management of MN has steadily advanced owing to the identification of autoantibodies to the phospholipase A2 receptor (PLA2R) i …
Membranous Nephropathy: Core Curriculum 2021.
Alsharhan L, Beck LH Jr. Alsharhan L, et al. Am J Kidney Dis. 2021 Mar;77(3):440-453. doi: 10.1053/j.ajkd.2020.10.009. Epub 2021 Jan 21. Am J Kidney Dis. 2021. PMID: 33487481 Review.
THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer.
Flockerzi FA, Hohneck J, Saar M, Bohle RM, Stahl PR. Flockerzi FA, et al. Diagnostics (Basel). 2023 Jan 7;13(2):221. doi: 10.3390/diagnostics13020221. Diagnostics (Basel). 2023. PMID: 36673031 Free PMC article.
THSD7A expression is significantly associated with unfavorable prognostic parameters in prostate cancer. ...To our knowledge we are the first to show that THSD7A positivity is associated with high FAK expression in prostate cancer. ...
THSD7A expression is significantly associated with unfavorable prognostic parameters in prostate cancer. ...To our knowledge w …
THSD7A expression in human cancer.
Stahl PR, Hoxha E, Wiech T, Schröder C, Simon R, Stahl RA. Stahl PR, et al. Genes Chromosomes Cancer. 2017 Apr;56(4):314-327. doi: 10.1002/gcc.22440. Epub 2017 Feb 6. Genes Chromosomes Cancer. 2017. PMID: 28035718
We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. ...The potential role of THSD7A in tumor development …
We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female p …
Integrated analysis of single-cell and bulk RNA-sequencing data reveals the prognostic value and molecular function of THSD7A in gastric cancer.
Shen K, Chen B, Yang L, Gao W. Shen K, et al. Aging (Albany NY). 2023 Oct 30;15(21):11940-11969. doi: 10.18632/aging.205158. Epub 2023 Oct 30. Aging (Albany NY). 2023. PMID: 37905960 Free PMC article.
Cox analysis showed that THSD7A was an independent risk factor for patients with gastric cancer. ...In vitro experiments confirmed that THSD7A was overexpressed in gastric cancer samples and cells, and that knocking out THSD7A significantly inhi …
Cox analysis showed that THSD7A was an independent risk factor for patients with gastric cancer. ...In vitro experiments confi …
Expression of THSD7A in neoplasm tissues and its relationship with proteinuria.
Xian L, Dong D, Luo J, Zhuo L, Li K, Zhang P, Wang W, Xu Y, Xu G, Wang L, Li G. Xian L, et al. BMC Nephrol. 2019 Aug 23;20(1):332. doi: 10.1186/s12882-019-1489-5. BMC Nephrol. 2019. PMID: 31443644 Free PMC article.
In this study, we investigated the histologic expression of THSD7A in colorectal or breast cancers, as well as the relationship between THSD7A expression and proteinuria in the patients with cancers. METHOD: A total of 101 patients were enrolled in the …
In this study, we investigated the histologic expression of THSD7A in colorectal or breast cancers, as well as the relationshi …
Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats.
Aktepe OH, Sahin TK, Guner G, Guven DC, Yeter HH, Kurtulan O, Ozercan IH, Dizdar O, Yalcin S. Aktepe OH, et al. Turk J Gastroenterol. 2021 Dec;32(12):1049-1056. doi: 10.5152/tjg.2021.20899. Turk J Gastroenterol. 2021. PMID: 34876395 Free PMC article.
BACKGROUND: Thrombospondin type 1 domain-containing 7A (THSD7A) has emerged as a new potential molecular tool for multiple tumors since that THSD7A was detected to be expressed in various malignant tumor types including colorectal cancer (CRC). Thus, we inves …
BACKGROUND: Thrombospondin type 1 domain-containing 7A (THSD7A) has emerged as a new potential molecular tool for multiple tumors sin …
PLA2R and THSD7A: Disparate Paths to the Same Disease?
Beck LH Jr. Beck LH Jr. J Am Soc Nephrol. 2017 Sep;28(9):2579-2589. doi: 10.1681/ASN.2017020178. Epub 2017 Jul 3. J Am Soc Nephrol. 2017. PMID: 28674044 Free PMC article. Review.
The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular subclasses of this disease. ...Although protocols similar to those that identified …
The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in prima …
Critical evaluation of cancer risks in glomerular disease.
Thet Z, Lam AK, Ranganathan D, Aung SY, Han T, Khoo TK. Thet Z, et al. Transl Oncol. 2022 May;19:101376. doi: 10.1016/j.tranon.2022.101376. Epub 2022 Feb 24. Transl Oncol. 2022. PMID: 35220046 Free PMC article. Review.
This review addresses overall cancer risks in individuals with glomerular diseases and employment of biomarkers available for MN. We propose a scheme of screening of cancers frequently reported in the setting of glomerular disease....
This review addresses overall cancer risks in individuals with glomerular diseases and employment of biomarkers available for MN. We …
THSD7A expression: a novel immunohistochemical determinant in predicting overall survival of metastatic renal cell carcinoma treated with targeted therapy.
Aktepe OH, Gundogdu F, Kosemehmetoglu K, Yeter HH, Aksoy S, Guven DC, Sahin TK, Yuce D, Kertmen N, Dizdar O, Yalcin S, Erman M. Aktepe OH, et al. Ir J Med Sci. 2022 Aug;191(4):1561-1567. doi: 10.1007/s11845-021-02759-0. Epub 2021 Sep 1. Ir J Med Sci. 2022. PMID: 34472040
RESULTS: THSD7A expression was determined in 77.9% of the patients. Kaplan-Meier analyses showed that while the patients with THSD7A expression had significantly inferior OS times than those with negative THSD7A expression (19.9 months vs. 52.2 months, P = 0. …
RESULTS: THSD7A expression was determined in 77.9% of the patients. Kaplan-Meier analyses showed that while the patients with THSD …
53 results