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219 results

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Page 1
TLE1 function and therapeutic potential in cancer.
Yuan D, Yang X, Yuan Z, Zhao Y, Guo J. Yuan D, et al. Oncotarget. 2017 Feb 28;8(9):15971-15976. doi: 10.18632/oncotarget.13278. Oncotarget. 2017. PMID: 27852056 Free PMC article. Review.
It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatme …
It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In thi …
TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin.
Yao X, Ireland SK, Pham T, Temple B, Chen R, Raj MH, Biliran H. Yao X, et al. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):277-84. doi: 10.1016/j.bbrc.2014.11.007. Epub 2014 Nov 15. Biochem Biophys Res Commun. 2014. PMID: 25446087 Free PMC article.
In this report, we investigated whether TLE1 regulates lung cancer aggressiveness using the human lung adenocarcinoma cell line A549 as a model system. ...These findings uncover a novel role of TLE1 in regulating EMT in A549 cells through its repressive effec …
In this report, we investigated whether TLE1 regulates lung cancer aggressiveness using the human lung adenocarcinoma cell lin …
TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.
Brunquell C, Biliran H, Jennings S, Ireland SK, Chen R, Ruoslahti E. Brunquell C, et al. Mol Cancer Res. 2012 Nov;10(11):1482-95. doi: 10.1158/1541-7786.MCR-12-0144. Epub 2012 Sep 4. Mol Cancer Res. 2012. PMID: 22952044 Free PMC article.
TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. ...In breast cancer cells, TLE1 expression was significantly …
TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular syste …
TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression.
Yao X, Pham T, Temple B, Gray S, Cannon C, Hardy C, Fletcher K, Ireland SK, Hossain A, Chen R, Abdel-Mageed AB, Biliran H. Yao X, et al. Oncotarget. 2017 Jul 31;8(42):72235-72249. doi: 10.18632/oncotarget.19703. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069783 Free PMC article.
Underscoring its role in anoikis insensitivity of lung cancer cells, the TLE1-mediated E-cadherin repression was negatively regulated by the tumor suppressor Bcl-2 inhibitor of transcription 1 (Bit1) to effect anoikis. These findings identify the ZEB1/TLE1/E- …
Underscoring its role in anoikis insensitivity of lung cancer cells, the TLE1-mediated E-cadherin repression was negatively re …
Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.
El Beaino M, Jupiter DC, Assi T, Rassy E, Lazar AJ, Araujo DM, Lin PP. El Beaino M, et al. Sarcoma. 2020 Jan 29;2020:7192347. doi: 10.1155/2020/7192347. eCollection 2020. Sarcoma. 2020. PMID: 32322158 Free PMC article. Review.
This systematic review examines the potential role of TLE1 as a diagnostic biomarker for the synovial sarcoma. Materials and Methods. ...CONCLUSION: TLE1 is a sensitive and specific marker for synovial sarcoma that can aid in its diagnosis. ...
This systematic review examines the potential role of TLE1 as a diagnostic biomarker for the synovial sarcoma. Materials and Methods. …
Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Kornspan D, Smith Y, Nechushtan H. Kornspan D, et al. Biochem Biophys Res Commun. 2021 Mar 19;545:164-170. doi: 10.1016/j.bbrc.2021.01.052. Epub 2021 Feb 8. Biochem Biophys Res Commun. 2021. PMID: 33571907
Here we demonstrate, using the TCGA data base, differences in expression of this gene compared to TLE1 in several cancers. In-vitro transduction of a retrovirus encoding TLE3 to A549 lung cancer cells increased paclitaxel effectivity while TLE1 introdu …
Here we demonstrate, using the TCGA data base, differences in expression of this gene compared to TLE1 in several cancers. In- …
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m(6)A modification.
Zhang QC, Qian YM, Ren YH, Chen MM, Cao LM, Zheng SJ, Li BB, Wang M, Wu X, Xu K. Zhang QC, et al. Acta Pharmacol Sin. 2024 Mar;45(3):619-632. doi: 10.1038/s41401-023-01178-4. Epub 2023 Oct 17. Acta Pharmacol Sin. 2024. PMID: 37848553
Isothiocyanates (ITCs) are natural compounds and inhibit the tumorigenesis of various cancers. Our previous studies show that ITCs inhibit the proliferation and metastasis of non-small cell lung cancer (NSCLC) cells, and have synergistic effects with chemotherapy dr …
Isothiocyanates (ITCs) are natural compounds and inhibit the tumorigenesis of various cancers. Our previous studies show that ITCs in …
Novel genes and sex differences in COVID-19 severity.
Cruz R, Diz-de Almeida S, López de Heredia M, Quintela I, Ceballos FC, Pita G, Lorenzo-Salazar JM, González-Montelongo R, Gago-Domínguez M, Sevilla Porras M, Tenorio Castaño JA, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M, Belhassen-Garcia M, Bezerra JF, Bezerra MAC, Boix-Palop L, Brion M, Brugada R, Bustos M, Calderón EJ, Carbonell C, Castano L, Castelao JE, Conde-Vicente R, Cordero-Lorenzana ML, Cortes-Sanchez JL, Corton M, Darnaude MT, De Martino-Rodríguez A, Del Campo-Pérez V, Diaz de Bustamante A, Domínguez-Garrido E, Luchessi AD, Eiros R, Estigarribia Sanabria GM, Carmen Fariñas M, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Villa T, Gil-Fournier B, Gómez-Arrue J, González Álvarez B, Gonzalez Bernaldo de Quirós F, González-Peñas J, Gutiérrez-Bautista JF, Herrero MJ, Herrero-Gonzalez A, Jimenez-Sousa MA, Lattig MC, Liger Borja A, Lopez-Rodriguez R, Mancebo E, Martín-López C, Martín V, Martinez-Nieto O, Martinez-Lopez I, Martinez-Resendez MF, Martinez-Perez A, Mazzeu JF, Merayo Macías E, Minguez P, Moreno Cuerda V, Silbiger V… See abstract for full author list ➔ Cruz R, et al. Hum Mol Genet. 2022 Nov 10;31(22):3789-3806. doi: 10.1093/hmg/ddac132. Hum Mol Genet. 2022. PMID: 35708486 Free PMC article.

In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 10-22 and P = 8.1 10-12, respectively), and for variants in 9q21.32 near

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In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 10-8) was crossed for

…
Frequent TLE1 Expression in Cutaneous Neoplasms.
Xiong Y, Dresser K, Cornejo KM. Xiong Y, et al. Am J Dermatopathol. 2019 Jan;41(1):1-6. doi: 10.1097/DAD.0000000000001186. Am J Dermatopathol. 2019. PMID: 30608261
TLE1 also labeled 19/20 (95%) BCCs and 12/19 (63%) SCCs. TLE1 immunohistochemistry frequently highlights sebaceous neoplasms, BCC, and SCC with a fairly high sensitivity (63%-96%). ...In addition, TLE1 does not seem to be useful in the diagnosis or cla …
TLE1 also labeled 19/20 (95%) BCCs and 12/19 (63%) SCCs. TLE1 immunohistochemistry frequently highlights sebaceous neoplasm …
A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma.
Baranov E, McBride MJ, Bellizzi AM, Ligon AH, Fletcher CDM, Kadoch C, Hornick JL. Baranov E, et al. Am J Surg Pathol. 2020 Jul;44(7):922-933. doi: 10.1097/PAS.0000000000001447. Am J Surg Pathol. 2020. PMID: 32141887 Free PMC article.
We validated the selectivity and specificity of the antibodies using immunoblotting, immunoprecipitation, and chromatin immunoprecipitation followed by next-generation sequencing in SS cell lines and demonstrated that both antibodies capture SS18-SSX on chromatin at established t …
We validated the selectivity and specificity of the antibodies using immunoblotting, immunoprecipitation, and chromatin immunoprecipitation …
219 results