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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2001 1
2005 1
2006 2
2007 1
2008 4
2011 3
2012 1
2014 2
2015 2
2016 7
2017 2
2018 2
2019 1
2020 2
2021 2
2022 1
2023 3
2024 0

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35 results

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Page 1
TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.
Wang SY, Gao K, Deng DL, Cai JJ, Xiao ZY, He LQ, Jiao HL, Ye YP, Yang RW, Li TT, Liang L, Liao WT, Ding YQ. Wang SY, et al. Oncotarget. 2016 Jan 19;7(3):2878-88. doi: 10.18632/oncotarget.6694. Oncotarget. 2016. PMID: 26701208 Free PMC article.
The Groucho transcriptional co-repressor TLE4 protein has been shown to be a tumor suppressor in a subset of acute myeloid leukemia. However, little is known about its role in development and progression of solid tumor. In this study, we found that the expression of TLE …
The Groucho transcriptional co-repressor TLE4 protein has been shown to be a tumor suppressor in a subset of acute myeloid leukemia. …
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies.
Wang D, Prager BC, Gimple RC, Aguilar B, Alizadeh D, Tang H, Lv D, Starr R, Brito A, Wu Q, Kim LJY, Qiu Z, Lin P, Lorenzini MH, Badie B, Forman SJ, Xie Q, Brown CE, Rich JN. Wang D, et al. Cancer Discov. 2021 May;11(5):1192-1211. doi: 10.1158/2159-8290.CD-20-1243. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328215 Free PMC article.
Screening of CAR T cells identified dependencies for effector functions, including TLE4 and IKZF2. Targeted knockout of these genes enhanced CAR antitumor efficacy. ...
Screening of CAR T cells identified dependencies for effector functions, including TLE4 and IKZF2. Targeted knockout of these genes e …
Potential role of CMPK1, SLC29A1, and TLE4 polymorphisms in gemcitabine-based chemotherapy in HER2-negative metastatic breast cancer patients: pharmacogenetic study results from the prospective randomized phase II study of eribulin plus gemcitabine versus paclitaxel plus gemcitabine (KCSG-BR-13-11).
Cho EH, Kim JY, Im SA, Jung KH, Sohn J, Lee KS, Chae YS, Lee KH, Kim JH, Jang JH, Ahn JH, Park MS, Lee SY, Park YH. Cho EH, et al. ESMO Open. 2021 Oct;6(5):100236. doi: 10.1016/j.esmoop.2021.100236. Epub 2021 Aug 23. ESMO Open. 2021. PMID: 34438242 Free PMC article. Clinical Trial.
BACKGROUND: In this study, we evaluated the association between genetic polymorphisms of 23 genes associated with gemcitabine metabolism and the clinical efficacy of gemcitabine in breast cancer patients. PATIENTS AND METHODS: This prospective, pharmacogenetic study was co …
BACKGROUND: In this study, we evaluated the association between genetic polymorphisms of 23 genes associated with gemcitabine metabolism and …
The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone development.
Wheat JC, Krause DS, Shin TH, Chen X, Wang J, Ding D, Yamin R, Sweetser DA. Wheat JC, et al. PLoS One. 2014 Aug 25;9(8):e105557. doi: 10.1371/journal.pone.0105557. eCollection 2014. PLoS One. 2014. PMID: 25153823 Free PMC article.
We report here that Tle4 knockout mice are runted and die at around four weeks with defects in bone development and BM aplasia. ...In the absence of Tle4 there is a profound decrease in bone mineralization. In addition, Tle4 knockout stromal cells are defecti …
We report here that Tle4 knockout mice are runted and die at around four weeks with defects in bone development and BM aplasia. ...In …
TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.
Shin TH, Brynczka C, Dayyani F, Rivera MN, Sweetser DA. Shin TH, et al. Leuk Res. 2016 Sep;48:46-56. doi: 10.1016/j.leukres.2016.07.002. Epub 2016 Jul 21. Leuk Res. 2016. PMID: 27486062 Free PMC article.
In studying del(9q), one of the most common concomitant chromosomal abnormalities with t(8;21), we identified the loss of an apparent tumor suppressor, TLE4, that appears to cooperate with AML1-ETO to confer a leukemic phenotype. ...We further demonstrate that inhibition o …
In studying del(9q), one of the most common concomitant chromosomal abnormalities with t(8;21), we identified the loss of an apparent tumor …
DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer.
Yu H, Wang X, Bai L, Tang G, Carter KT, Cui J, Huang P, Liang L, Ding Y, Cai M, Huang M, Liu H, Cao G, Gallinger S, Pai RK, Buchanan DD, Win AK, Newcomb PA, Wang J, Grady WM, Luo Y. Yu H, et al. J Natl Cancer Inst. 2023 Jan 10;115(1):52-61. doi: 10.1093/jnci/djac183. J Natl Cancer Inst. 2023. PMID: 36171645 Free PMC article.
BACKGROUND: The current risk stratification system defined by clinicopathological features does not identify the risk of recurrence in early-stage (stage I-II) colorectal cancer (CRC) with sufficient accuracy. We aimed to investigate whether DNA methylation could serve as …
BACKGROUND: The current risk stratification system defined by clinicopathological features does not identify the risk of recurrence in early …
Down-regulation of Transducin-Like Enhancer of Split protein 4 in hepatocellular carcinoma promotes cell proliferation and epithelial-Mesenchymal-Transition.
Wu XC, Xiao CC, Li H, Tai Y, Zhang Q, Yang Y. Wu XC, et al. Biochem Biophys Res Commun. 2016 Aug 19;477(2):161-6. doi: 10.1016/j.bbrc.2016.06.037. Epub 2016 Jun 11. Biochem Biophys Res Commun. 2016. PMID: 27297112
BACKGROUND: Transducin-Like Enhancer of Split protein 4 (TLE4) has been reported to be involved in some subsets of acute myeloid leukemia and colorectal cancer. In the present study, we aimed to explore the role of TLE4 in tumorigenesis and cancer prog …
BACKGROUND: Transducin-Like Enhancer of Split protein 4 (TLE4) has been reported to be involved in some subsets of acute myeloid leuk …
Pathway and network analysis of more than 2500 whole cancer genomes.
Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, von Mering C, Sahinalp SC, Valencia A; PCAWG Drivers and Functional Interpretation Working Group; Reimand J, Stuart JM, Raphael BJ; PCAWG Consortium. Reyna MA, et al. Nat Commun. 2020 Feb 5;11(1):729. doi: 10.1038/s41467-020-14367-0. Nat Commun. 2020. PMID: 32024854 Free PMC article.
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. ...Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer a …
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. ...Here, as part of the ICGC/ …
Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia.
Mrózek K, Marcucci G, Paschka P, Bloomfield CD. Mrózek K, et al. Curr Opin Oncol. 2008 Nov;20(6):711-8. doi: 10.1097/CCO.0b013e32831369df. Curr Opin Oncol. 2008. PMID: 18841055 Free PMC article. Review.
Alterations that may represent cooperative events in CBF-AML leukemogenesis include mutations in the KIT, FLT3, JAK2 and RAS genes, haploinsufficiency of the putative tumor suppressor genes TLE1 and TLE4 in t(8;21)-positive patients with del(9q), MN1 overexpression in inv( …
Alterations that may represent cooperative events in CBF-AML leukemogenesis include mutations in the KIT, FLT3, JAK2 and RAS genes, haploins …
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE, Bernstein ID, Peterson RT, Sweetser DA. Dayyani F, et al. Blood. 2008 Apr 15;111(8):4338-47. doi: 10.1182/blood-2007-07-103291. Epub 2008 Feb 7. Blood. 2008. PMID: 18258796 Free PMC article.
To determine the critical lost gene(s) that might cooperate with the AML1-ETO fusion gene produced by t(8;21), we developed a set of shRNAs directed against each gene in this region. Within this library, shRNAs to TLE1 and TLE4 were the only shRNAs capable of rescuing AML1 …
To determine the critical lost gene(s) that might cooperate with the AML1-ETO fusion gene produced by t(8;21), we developed a set of shRNAs …
35 results