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Assessment of TLL1 variant and risk of hepatocellular carcinoma in Latin Americans and Europeans.
Fu S, Karim D, Prieto J, Balderramo D, Ferrer JD, Mattos AZ, Arrese M, Carrera E, Oliveira J, Debes JD, Boonstra A. Fu S, et al. Ann Hepatol. 2024 Mar-Apr;29(2):101181. doi: 10.1016/j.aohep.2023.101181. Epub 2023 Nov 20. Ann Hepatol. 2024. PMID: 37981236 Free article.
INTRODUCTION AND OBJECTIVES: Tolloid like protein 1 (TLL1) rs17047200 has been reported to be associated with HCC development and liver fibrosis. ...A larger study integrating ethnic and etiology backgrounds is needed to determine the importance of the TLL1 SNP in H …
INTRODUCTION AND OBJECTIVES: Tolloid like protein 1 (TLL1) rs17047200 has been reported to be associated with HCC development and liv …
TLL1 variants do not predict hepatocellular carcinoma development in HCV cirrhotic patients treated with direct-acting antivirals.
Degasperi E, Galmozzi E, Facchetti F, Farina E, D'Ambrosio R, Soffredini R, Iavarone M, Lampertico P. Degasperi E, et al. J Viral Hepat. 2019 Oct;26(10):1233-1236. doi: 10.1111/jvh.13155. Epub 2019 Jun 30. J Viral Hepat. 2019. PMID: 31177595 Free article. Clinical Trial.
TLL1 genotype was AA in 329 (73%) and AT/TT in 123 (27%) (MAF = 0.14, HWE P > 0.05). ...In a large cohort of Caucasian HCV cirrhotics treated with DAA, TLL1 variants do not predict HCC development....
TLL1 genotype was AA in 329 (73%) and AT/TT in 123 (27%) (MAF = 0.14, HWE P > 0.05). ...In a large cohort of Caucasian HCV cirrhot …
Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, Namisaki T, Yoshiji H, Sakamoto N, Nakagawa M, Asahina Y, Kurosaki M, Izumi N, Enomoto N, Kusakabe A, Kajiwara E, Itoh Y, Ide T, Tamori A, Matsubara M, Kawada N, Shirabe K, Tomita E, Honda M, Kaneko S, Nishina S, Suetsugu A, Hiasa Y, Watanabe H, Genda T, Sakaida I, Nishiguchi S, Takaguchi K, Tanaka E, Sugihara J, Shimada M, Kondo Y, Kawai Y, Kojima K, Nagasaki M, Tokunaga K, Tanaka Y; Japanese Genome-Wide Association Study Group for Viral Hepatitis. Matsuura K, et al. Gastroenterology. 2017 May;152(6):1383-1394. doi: 10.1053/j.gastro.2017.01.041. Epub 2017 Feb 3. Gastroenterology. 2017. PMID: 28163062 Free article.
Levels of TLL1 mRNA increased in liver tissues of patients with progression of fibrosis. ...We found levels of Tll1/TLL1 mRNA to be increased in rodent models of liver injury and liver tissues of patients with fibrosis, compared with controls. ...
Levels of TLL1 mRNA increased in liver tissues of patients with progression of fibrosis. ...We found levels of Tll1/TLL1 …
TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus by interferon-free therapy.
Iio E, Matsuura K, Shimada N, Atsukawa M, Itokawa N, Abe H, Kato K, Takaguchi K, Senoh T, Eguchi Y, Nomura H, Yoshizawa K, Kang JH, Matsui T, Hirashima N, Kusakabe A, Miyaki T, Fujiwara K, Matsunami K, Tsutsumi S, Iwakiri K, Tanaka Y. Iio E, et al. J Gastroenterol. 2019 Apr;54(4):339-346. doi: 10.1007/s00535-018-1526-3. Epub 2018 Oct 31. J Gastroenterol. 2019. PMID: 30382363
BACKGROUND: The aim of this study is to ascertain whether the TLL1 variant at rs17047200 is associated with the development of HCC after achieving sustained virological response (SVR) by interferon (IFN)-free therapy for chronic hepatitis C (CHC). ...CONCLUSIONS: The TL …
BACKGROUND: The aim of this study is to ascertain whether the TLL1 variant at rs17047200 is associated with the development of HCC af …
The Role of the Extracellular Matrix and Tumor-Infiltrating Immune Cells in the Prognostication of High-Grade Serous Ovarian Cancer.
Belotti Y, Lim EH, Lim CT. Belotti Y, et al. Cancers (Basel). 2022 Jan 14;14(2):404. doi: 10.3390/cancers14020404. Cancers (Basel). 2022. PMID: 35053566 Free PMC article.
Ovarian cancer is the eighth global leading cause of cancer-related death among women. ...Recent research linked onset, progression, and response to treatment with dysregulated components of the tumor microenvironment (TME) in many types of cancer. In this st …
Ovarian cancer is the eighth global leading cause of cancer-related death among women. ...Recent research linked onset, progre …
An artificial intelligence prediction model based on extracellular matrix proteins for the prognostic prediction and immunotherapeutic evaluation of ovarian serous adenocarcinoma.
Geng T, Zheng M, Wang Y, Reseland JE, Samara A. Geng T, et al. Front Mol Biosci. 2023 Jun 14;10:1200354. doi: 10.3389/fmolb.2023.1200354. eCollection 2023. Front Mol Biosci. 2023. PMID: 37388244 Free PMC article.
Background: Ovarian Serous Adenocarcinoma is a malignant tumor originating from epithelial cells and one of the most common causes of death from gynecological cancers. The objective of this study was to develop a prediction model based on extracellular matrix proteins, usi …
Background: Ovarian Serous Adenocarcinoma is a malignant tumor originating from epithelial cells and one of the most common causes of death …
The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases.
Odagiri H, Kadomatsu T, Endo M, Masuda T, Morioka MS, Fukuhara S, Miyamoto T, Kobayashi E, Miyata K, Aoi J, Horiguchi H, Nishimura N, Terada K, Yakushiji T, Manabe I, Mochizuki N, Mizuta H, Oike Y. Odagiri H, et al. Sci Signal. 2014 Jan 21;7(309):ra7. doi: 10.1126/scisignal.2004612. Sci Signal. 2014. PMID: 24448647
ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin alpha5beta1, p38 mitogen-activated protein kinase, and matrix metalloproteinases. The tolloid-like 1 (TLL …
ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intrava …
Hepatocellular Carcinoma Risk Stratification by Genetic Profiling in Patients with Cirrhosis.
Fujiwara N, Hoshida Y. Fujiwara N, et al. Semin Liver Dis. 2019 May;39(2):153-162. doi: 10.1055/s-0039-1681031. Epub 2019 Mar 25. Semin Liver Dis. 2019. PMID: 30912093 Free PMC article.
Germline deoxyribonucleic acid polymorphisms likely represent etiology-specific host factors that determine HCC susceptibility, including single nucleotide polymorphisms in EGF, IFNL3, MICA, and TLL1 in hepatitis C with or without active viral infection, and PNPLA3, TM6SF2 …
Germline deoxyribonucleic acid polymorphisms likely represent etiology-specific host factors that determine HCC susceptibility, including si …
15 results