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TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.
Letran SE, Lee SJ, Atif SM, Uematsu S, Akira S, McSorley SJ. Letran SE, et al. Eur J Immunol. 2011 Jan;41(1):29-38. doi: 10.1002/eji.201040717. Epub 2010 Dec 3. Eur J Immunol. 2011. PMID: 21182074 Free PMC article.
Here, we demonstrate a previously unknown function for TLR5, namely that it enhances MHC class-II presentation of flagellin epitopes to CD4(+) T cells and is required for induction of robust flagellin-specific adaptive immune responses. . …
Here, we demonstrate a previously unknown function for TLR5, namely that it enhances MHC class-II presentation of flagellin …
Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting alphaCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells.
Schmitt S, Tahk S, Lohner A, Hänel G, Maiser A, Hauke M, Patel L, Rothe M, Josenhans C, Leonhardt H, Griffioen M, Deiser K, Fenn NC, Hopfner KP, Subklewe M. Schmitt S, et al. Front Immunol. 2020 Nov 12;11:602802. doi: 10.3389/fimmu.2020.602802. eCollection 2020. Front Immunol. 2020. PMID: 33281829 Free PMC article.
In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo with antibody-antigen conjugates co-administered with toll-like receptor (TLR) agonists as adjuvants. ...We validated its functionality in vitro and d …
In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo with antibody-antigen conjugate …