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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1951 1
1952 1
1955 1
1956 2
1957 1
1958 3
1959 1
1960 1
1962 2
1963 2
1964 1
1965 1
1967 1
1970 1
1976 1
1977 2
1978 4
1979 1
1980 2
1981 6
1982 5
1983 5
1984 8
1985 8
1986 6
1987 8
1988 6
1989 7
1990 8
1991 10
1992 11
1993 13
1994 12
1995 17
1996 9
1997 16
1998 26
1999 20
2000 28
2001 30
2002 26
2003 43
2004 40
2005 49
2006 40
2007 48
2008 38
2009 39
2010 44
2011 47
2012 47
2013 69
2014 84
2015 127
2016 151
2017 169
2018 206
2019 240
2020 303
2021 325
2022 362
2023 270
2024 153

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2,891 results

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Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease.
Thomas MS, Fernandez ML. Thomas MS, et al. Curr Atheroscler Rep. 2021 Feb 17;23(4):12. doi: 10.1007/s11883-021-00910-x. Curr Atheroscler Rep. 2021. PMID: 33594574 Review.
While epidemiologic research shows a causal relationship between plasma TMAO concentrations and CVD risk, the role of dietary precursors in determining plasma concentrations of TMAO and biomarkers for CVD is inconclusive. ...TMAO is an important plasma metabo …
While epidemiologic research shows a causal relationship between plasma TMAO concentrations and CVD risk, the role of dietary precurs …
TMAO: how gut microbiota contributes to heart failure.
Zhang Y, Wang Y, Ke B, Du J. Zhang Y, et al. Transl Res. 2021 Feb;228:109-125. doi: 10.1016/j.trsl.2020.08.007. Epub 2020 Aug 22. Transl Res. 2021. PMID: 32841736 Free article. Review.
In this review, we mainly discuss a newly identified gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which appears to participate in the pathologic processes of HF and can serve as an early warning marker to identify individuals who are at the risk of d …
In this review, we mainly discuss a newly identified gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which appear …
Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target.
Janeiro MH, Ramírez MJ, Milagro FI, Martínez JA, Solas M. Janeiro MH, et al. Nutrients. 2018 Oct 1;10(10):1398. doi: 10.3390/nu10101398. Nutrients. 2018. PMID: 30275434 Free PMC article. Review.
In this article, we reviewed dietary sources and metabolic pathways of TMAO, as well as screened the studies suggesting possible involvement of TMAO in the etiology of cardiovascular and neurological disorders, underlying the importance of TMAO mediating infl …
In this article, we reviewed dietary sources and metabolic pathways of TMAO, as well as screened the studies suggesting possible invo …
TMAO to the rescue of pathogenic protein variants.
Kumari K, Singh KS, Singh K, Bakhshi R, Singh LR. Kumari K, et al. Biochim Biophys Acta Gen Subj. 2022 Nov;1866(11):130214. doi: 10.1016/j.bbagen.2022.130214. Epub 2022 Jul 25. Biochim Biophys Acta Gen Subj. 2022. PMID: 35902028 Review.
Trimethylamine N-oxide (TMAO) is a chemical chaperone found in various organisms including humans. ...The present review has been designed to gather a comprehensive knowledge of the TMAO's effect on the functional restoration of various mutants, identify its shortco …
Trimethylamine N-oxide (TMAO) is a chemical chaperone found in various organisms including humans. ...The present review has been des …
TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies.
Zhang WQ, Wang YJ, Zhang A, Ding YJ, Zhang XN, Jia QJ, Zhu YP, Li YY, Lv SC, Zhang JP. Zhang WQ, et al. J Cardiovasc Transl Res. 2021 Dec;14(6):1117-1124. doi: 10.1007/s12265-021-10115-x. Epub 2021 Mar 11. J Cardiovasc Transl Res. 2021. PMID: 33709384 Review.
It is strongly linked with physiological and pathological systems, especially TMA and TMAO. TMA is formed by intestinal microbial metabolism of choline and L-carnitine and converted into TMAO by FMO3. ...And, more relevant studies are still prospected to be accompli …
It is strongly linked with physiological and pathological systems, especially TMA and TMAO. TMA is formed by intestinal microbial met …
Protein Stability in TMAO and Mixed Urea-TMAO Solutions.
Ganguly P, Polák J, van der Vegt NFA, Heyda J, Shea JE. Ganguly P, et al. J Phys Chem B. 2020 Jul 23;124(29):6181-6197. doi: 10.1021/acs.jpcb.0c04357. Epub 2020 Jun 25. J Phys Chem B. 2020. PMID: 32495623 Review.
This Review aims at providing a detailed account of recent theoretical and experimental developments in characterizing the structural changes and thermodynamic stability of proteins in the presence of TMAO and urea. New vapor pressure osmometry and molecular dynamics simul …
This Review aims at providing a detailed account of recent theoretical and experimental developments in characterizing the structural change …
Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer.
Jalandra R, Dalal N, Yadav AK, Verma D, Sharma M, Singh R, Khosla A, Kumar A, Solanki PR. Jalandra R, et al. Appl Microbiol Biotechnol. 2021 Oct;105(20):7651-7660. doi: 10.1007/s00253-021-11582-7. Epub 2021 Sep 27. Appl Microbiol Biotechnol. 2021. PMID: 34568962 Review.
In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvement of TMAO in the carcinogenesis of CRC. ...We believe, this review will augment the understanding of linking TMAO with CRC a …
In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvem …
TMAO: A small molecule of great expectations.
Ufnal M, Zadlo A, Ostaszewski R. Ufnal M, et al. Nutrition. 2015 Nov-Dec;31(11-12):1317-23. doi: 10.1016/j.nut.2015.05.006. Epub 2015 Jun 1. Nutrition. 2015. PMID: 26283574 Review.
Although in humans TMAO is known mainly as a waste product of choline metabolism, a number of studies suggest an involvement of TMAO in important biological functions in numerous organisms, ranging from bacteria to mammals. ...In this article, we reviewed well-estab …
Although in humans TMAO is known mainly as a waste product of choline metabolism, a number of studies suggest an involvement of TM …
Amelioration of TMAO through probiotics and its potential role in atherosclerosis.
Din AU, Hassan A, Zhu Y, Yin T, Gregersen H, Wang G. Din AU, et al. Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9217-9228. doi: 10.1007/s00253-019-10142-4. Epub 2019 Oct 26. Appl Microbiol Biotechnol. 2019. PMID: 31655880 Review.
TMAO is generated from its dietary precursors choline, carnitine, and phosphatidylcholine by gut microbiota into an intermediate compound known as trimethylamine (TMA), which is then oxidized into TMAO by hepatic flavin monooxygenases. The present review focus on ad …
TMAO is generated from its dietary precursors choline, carnitine, and phosphatidylcholine by gut microbiota into an intermediate comp …
Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite.
Querio G, Antoniotti S, Geddo F, Levi R, Gallo MP. Querio G, et al. Int J Mol Sci. 2023 Mar 18;24(6):5806. doi: 10.3390/ijms24065806. Int J Mol Sci. 2023. PMID: 36982880 Free PMC article. Review.
In particular, the direct involvement of trimethylamine N-oxide (TMAO) in the development of endothelial dysfunction and its derived pathological outcomes, such as atherosclerosis, has come to light. ...The aim of this review is to present the latest studies that describe …
In particular, the direct involvement of trimethylamine N-oxide (TMAO) in the development of endothelial dysfunction and its derived …
2,891 results