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Comprehensive analysis of the prognosis and immune infiltration of TMC family members in renal clear cell carcinoma.
Tang W, Shi Z, Zhu Y, Shan Z, Jiang A, Wang A, Chen M, Bao Y, Ju G, Xu W, Wang J. Tang W, et al. Sci Rep. 2023 Jul 19;13(1):11668. doi: 10.1038/s41598-023-38914-z. Sci Rep. 2023. PMID: 37468683 Free PMC article.
Renal cancer is a common malignancy of the urinary system, and renal clear cell carcinoma (RCCC) is the most common pathological type. ...TMC3, TMC6, and TMC8 was positively correlated with the degree of immune infiltration in RCCC. ...
Renal cancer is a common malignancy of the urinary system, and renal clear cell carcinoma (RCCC) is the most common pathological type …
Identification of lipid metabolism-related genes as prognostic indicators in papillary thyroid cancer.
Wen S, Luo Y, Wu W, Zhang T, Yang Y, Ji Q, Wu Y, Shi R, Ma B, Xu M, Qu N. Wen S, et al. Acta Biochim Biophys Sin (Shanghai). 2021 Dec 8;53(12):1579-1589. doi: 10.1093/abbs/gmab145. Acta Biochim Biophys Sin (Shanghai). 2021. PMID: 34693452 Free article.
Lipid metabolism plays important roles not only in the structural basis and energy supply of healthy cells but also in the oncogenesis and progression of cancers. In this study, we investigated the prognostic value of lipid metabolism-related genes in papillary thyroid …
Lipid metabolism plays important roles not only in the structural basis and energy supply of healthy cells but also in the oncogenesis and p …
Cross-talk of Three Molecular Subtypes of Telomere Maintenance Defines Clinical Characteristics and Tumor Microenvironment in Gastric Cancer.
Yan M, Zhang Z, Wang L, Huang H, Wang J, Zhu C, Li Z, Xu Z. Yan M, et al. J Cancer. 2024 Apr 15;15(10):3227-3241. doi: 10.7150/jca.92207. eCollection 2024. J Cancer. 2024. PMID: 38706908 Free PMC article.
Background: Telomere maintenance takes part in the regulation of gastric cancer (GC) pathogenesis and is essential for patients' clinical features. ...Results: TMC1 was correlated with EMT and TGF-beta pathway and predicted low tumor mutation burden (TMB) as well as bad pr …
Background: Telomere maintenance takes part in the regulation of gastric cancer (GC) pathogenesis and is essential for patients' clin …
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Toonen LJA, Overzier M, Evers MM, Leon LG, van der Zeeuw SAJ, Mei H, Kielbasa SM, Goeman JJ, Hettne KM, Magnusson OT, Poirel M, Seyer A, 't Hoen PAC, van Roon-Mom WMC. Toonen LJA, et al. Mol Neurodegener. 2018 Jun 22;13(1):31. doi: 10.1186/s13024-018-0261-9. Mol Neurodegener. 2018. PMID: 29929540 Free PMC article.
The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, alpha-adrenergic and CREB pathways were most consistently altered for combined analysis of the four brain regions. ...
The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, alp …
Integrated multi-omics data analyses for exploring the co-occurring and mutually exclusive gene alteration events in colorectal cancer.
Zhou Y, Cheng X, Zhang F, Chen Q, Chen X, Shen Y, Lai C, Kota VG, Sun W, Huang Q, Yuan Y, Wang J, Lai M, Zhang D. Zhou Y, et al. Hum Mutat. 2020 Sep;41(9):1588-1599. doi: 10.1002/humu.24059. Epub 2020 Jul 5. Hum Mutat. 2020. PMID: 32485022
We conducted pairwise screening tests to identify "hit pairs" in colorectal cancer (CRC) by utilizing the cross-omics data from The Cancer Genome Atlas (TCGA). ...Our further biological experiments showed that the co-occurrence of mutant FCGBP and NUDT12 silencing ( …
We conducted pairwise screening tests to identify "hit pairs" in colorectal cancer (CRC) by utilizing the cross-omics data from The …
Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.
Kurima K, Yang Y, Sorber K, Griffith AJ. Kurima K, et al. Genomics. 2003 Sep;82(3):300-8. doi: 10.1016/s0888-7543(03)00154-x. Genomics. 2003. PMID: 12906855
TMC1 and a related gene, TMC2, are the founding members of a novel gene family. Here we describe six additional TMC paralogs (TMC3 to TMC8) in humans and mice, as well as homologs in other species. cDNAs spanning the full length of the predicted open reading frames of the …
TMC1 and a related gene, TMC2, are the founding members of a novel gene family. Here we describe six additional TMC paralogs (TMC3 to …
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
Tang W, Kowgier M, Loth DW, Soler Artigas M, Joubert BR, Hodge E, Gharib SA, Smith AV, Ruczinski I, Gudnason V, Mathias RA, Harris TB, Hansel NN, Launer LJ, Barnes KC, Hansen JG, Albrecht E, Aldrich MC, Allerhand M, Barr RG, Brusselle GG, Couper DJ, Curjuric I, Davies G, Deary IJ, Dupuis J, Fall T, Foy M, Franceschini N, Gao W, Gläser S, Gu X, Hancock DB, Heinrich J, Hofman A, Imboden M, Ingelsson E, James A, Karrasch S, Koch B, Kritchevsky SB, Kumar A, Lahousse L, Li G, Lind L, Lindgren C, Liu Y, Lohman K, Lumley T, McArdle WL, Meibohm B, Morris AP, Morrison AC, Musk B, North KE, Palmer LJ, Probst-Hensch NM, Psaty BM, Rivadeneira F, Rotter JI, Schulz H, Smith LJ, Sood A, Starr JM, Strachan DP, Teumer A, Uitterlinden AG, Völzke H, Voorman A, Wain LV, Wells MT, Wilk JB, Williams OD, Heckbert SR, Stricker BH, London SJ, Fornage M, Tobin MD, O'Connor GT, Hall IP, Cassano PA. Tang W, et al. PLoS One. 2014 Jul 1;9(7):e100776. doi: 10.1371/journal.pone.0100776. eCollection 2014. PLoS One. 2014. PMID: 24983941 Free PMC article.
RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 10(-7)). In addition, meta-analysis using the five cohorts with 3 FEV1 measurements per participant identified the novel ME3 locus …
RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 …
Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.
Kaelberer MM, Caceres AI, Jordt SE. Kaelberer MM, et al. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L953-L964. doi: 10.1152/ajplung.00403.2019. Epub 2020 Mar 11. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32159971 Free PMC article.
Unique JNC-specific transcripts, present at only minimal levels in TG, DRG, and other organs, were identified. These included TMC3, encoding for a putative mechanosensor, and urotensin 2B, a hypertensive peptide. ...
Unique JNC-specific transcripts, present at only minimal levels in TG, DRG, and other organs, were identified. These included TMC3, e …